Constituintes químicos e atividade Leishmanicida de Gustavia elliptica (Lecythidaceae)

Almeida, Maria de Fátima Oliveira; Melo, Ana C. R.; Pinheiro, Maria Lúcia B.; Silva, Jefferson Rocha de Andrade; Souza, Afonso Duarte Leão de; Barison, Andersson; Campos, Francinete Ramos; Amaral, Ana Cláudia F.; Machado, Gérzia Maria de Carvalho; Leon, Leonor L.

doi:10.1590/s0100-40422011000700015

Cited by 25 publications

(15 citation statements)

References 12 publications

(19 reference statements)

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“…A previous phytochemical investigation found that the chloroform fraction of the CBE of S. grantii contained terpenes and phenolic compounds [9]. In this work, the pentacyclic triterpenes friedelin [33,34] and 3β-friedelinol [33], and the tetracyclic triterpenes euphol and lanosterol [17,18], were isolated from the CBE of S. grantii (l " Fig. 3).…”

Section: Resultssupporting

confidence: 52%

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Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

et al. 2014

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Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, such as 2,2'-azino-bis (3-ethylenebenzothiazoline-6-sulfonic acid)• +, 1-diphenyl-2-picrylhydrazyl•, O2 • - , and HOCl, as well as an enzymatic system with human myeloperoxidase and an ex vivo hemolysis system. Furthermore, the oral administration of the crude bark extract was able to reduce carrageenan-induced rat paw edema as effectively as ibuprofen. These biological activities may be associated with the presence of flavonoids and terpenes, as revealed by HPLC and NMR analyses of the crude stem bark extract. The phytochemical investigations in this study resulted in the isolation of friedelin and 3β-friedelinol for the first time, while euphol and lanosterol were also isolated.

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Section: Resultssupporting

confidence: 52%

“…3). The structures of the compounds were established on the basis of extensive analysis of NMR data as well as comparison with literature data [17,18,33,34] (see Spectral assignments, Supporting Information). The NMR analysis of the fractions obtained from chromatographic separation of CBE showed characteristic signals due to terpenes.…”

Section: Resultsmentioning

confidence: 99%

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

et al. 2014

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“…The phytochemical study of HEXF, DCMF, and EAF fractions obtained from aerial parts of ruzigrass yielded eight compounds, and the structures of the compounds were established by comparison of their spectroscopic 1D and 2D NMR data with those reported in the literature. The HEXF fraction afforded three triterpenes, friedelin ( 1 ), oleanolic acid ( 2 ) and α ‐amyrin ( 3 ), and one steroidal sapogenin, 1‐dehydrodiosgenone ( 4 ) . Friedelin ( 1 ), two glycoside phytosterols, sitosterol 3‐ O ‐glucoside ( 5 ) and stigmasterol 3‐ O ‐glucoside ( 6 ), and one flavone, tricin ( 7 ), were obtained from the DMF fraction .…”

Section: Resultsmentioning

confidence: 99%

Chemical Characterization and Phytotoxic Effects of the Aerial Parts of Ruzigrass (Urochloa ruziziensis)

Moreno

Mantovanelli

Ricardo

et al. 2020

Chemistry & Biodiversity

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Studies of the phytotoxic effects between plants can be a crucial tool in the discovery of innovative compounds with herbicide potential. In this sense, we can highlight ruzigrass (Urochloa ruziziensis), which is traditionally used in the crop rotation system in order to reduce weed emergence. The aim of this work was to characterize the secondary metabolites of ruzigrass and to evaluate its phytotoxic effects. In total, eight compounds were isolated: friedelin, oleanolic acid, α‐amyrin, 1‐dehydrodiosgenone, sitosterol and stigmasterol glycosides, tricin and p‐coumaric acid. Phytotoxic effects of the crude methanolic extract and fractions of ruzigrass were assessed using germination rate, initial seedling growth, and biomass of Bidens pilosa, Euphorbia heterophylla and Ipomoea grandifolia. Chemometric analysis discriminated the weed species into three groups, and B. pilosa was the most affected by fractions of ruzigrass. The phytotoxic activities of 1‐dehydrodiosgenone, tricin, and p‐coumaric acid are also reported, and p‐coumaric acid and 1‐dehydrodiosgenone were active against B. pilosa.

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“…Hexane eluates of several plant species from the Amazon region have shown anti-parasitic activities against Leishmania promastigotes; these include Annona foetida (20) , Garcinia brasiliensis (21) , and Lacistema pubescens (22) against L. amazonensis, Gustavia elliptica against L. braziliensis (23) , and Guarea kunthiana and Casearia sylvestris against L. donovani (24) .…”

Section: Discussionmentioning

confidence: 99%

Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon

Meneguetti

Lima

Hurtado

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:Maytenus guianensis is a member of the Celastraceae family that is used in traditional medicine, particularly for its anti-parasitic and anti-cancer effects. To explore the ethnopharmacological potential of this plant, the present study was designed to screen the in vitro antileishmanial activities of extracts and compounds isolated from M. guianensis. Methods: Maytenus guianensis stems and leaves were extracted in acetone, followed by the preparation of eluates and isolation of secondary metabolites using chromatography on a glass column with silica gel as the fixed phase. The chemical components were identified using spectroscopic methods, including one-and two-dimensional nuclear magnetic resonance of hydrogen-1 and carbon-13, mass spectroscopy, and infrared spectroscopy. The anti-Leishmania amazonensis activities of these eluates and compounds were evaluated by direct promastigote counting and viability assays. Results: It was found that the hexane bark eluate produced the strongest anti-L. amazonensis effect, with 90-100% inhibition of the promastigote form. The isolated metabolite that produced the best result was tingenone B, followed by a compound formed by the union of tingenone and tingenone B (80-90% inhibition). Conclusions: Maytenus guianensis shows anti-parasite activity that warrants further investigation to determine the mechanisms underlying this antileishmanial effect and to evaluate the pharmacological potential of these eluates and isolated secondary metabolites, while minimizing any adverse effects.

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Constituintes químicos e atividade Leishmanicida de Gustavia elliptica (Lecythidaceae)

Cited by 25 publications

References 12 publications

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

Chemical Characterization and Phytotoxic Effects of the Aerial Parts of Ruzigrass (Urochloa ruziziensis)

Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon

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