Constituents of <i>Clinopodium Umbrosum</i>

Lee, Shu-Mei; Jeng-Shiow, Lai; Kuo, Yueh‐Hsiung

doi:10.1002/jccs.199300014

Cited by 12 publications

(2 citation statements)

References 12 publications

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“…In recent years, several papers have described phytochemistry investigations of various species of Clinopodium and it was found to be rich in saponins 3,4 , flavones 5,6 , polyphenols 7,8 , terpenes 9,10 , etc. C. urticifolium belongs to the Clinopodium genus, which widely distributed in Shanxi, Gansu and Ningxia, northwest of China. In previous work, some bioactive compounds were isolated from this plant 9,11,12 . Motivated by search for bioactive metabolites from this plant, a reinvestigation the chemical constituents of the whole plant of C. urticifolium were carried out.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from Clinopodium urticifolium and Their Antivirus Activities

Pan¹,

Huang²,

Gao³

et al. 2013

Asian J. Chem.

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A new phenolic compound, clinopodphenol B (1), together with six known phenols, were isolated from the whole plant of Clinopodium urticifolium. The structure of 1 was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compound 1 was also tested for their anti HIV-1 activity and antitobacco mosaic virus activity. The results showed that compound 1 have modest anti HIV-1 activity and anti-tobacco mosaic virus activity, respectively.

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Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from Clinopodium urticifolium and Their Antivirus Activities

Pan¹,

Huang²,

Gao³

et al. 2013

Asian J. Chem.

View full text Add to dashboard Cite

show abstract

“…Clinopodium urticifolium belongs to the Clinopodium genus, which widely distributed in Gansu, shaanxi, ningxia, in northwest China. In previous work, some bioactive compounds were isolated from this plant 8,11,12 . Motivated by a search for bioactive metabolites from this plant, a reinvestigation for the chemical constituents of the whole plant of C. urticifolium were carried out.…”

mentioning

confidence: 99%

Pterocarpan Derivatives from Clinopodium urticifolium and Their Cytotoxicity

Niu¹,

Li²,

Wu³

et al. 2013

Asian J. Chem.

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Clinopodium genus species are popular traditional Chinese medicinal herbs used to treat bruises and swelling and are also purported to improve blood circulation 1,2 . In recent years, several papers have described phytochemistry investigations of various species of clinopodium and it was found to be rich in saponins 3,4 , flavones 5,6 , polyphenols 7,8 , terpenes 9,10 , etc. Clinopodium urticifolium belongs to the Clinopodium genus, which widely distributed in Gansu, shaanxi, ningxia, in northwest China. In previous work, some bioactive compounds were isolated from this plant 8,11,12 . Motivated by a search for bioactive metabolites from this plant, a reinvestigation for the chemical constituents of the whole plant of C. urticifolium were carried out. As a result, a new pterocarpan (1), together with four known pterocarpan derivatives (2-5), were isolated from this plant. In addition, the cytotoxicity of compound 1 was evaluated. This work deals with the isolation, structural elucidation and biological activities of the new compound. EXPERIMENTALOptical rotations were measured with a Horiba SEPA-300 polarimeter. UV spectra were obtained using a Shimadzu UV-2401A spectrophotometer. CD spectra were measured on a JASCO J-810 spectropolarimeter. A Tenor 27 spectrophotometer was used for scanning IR spectroscopy with KBr pellets. 1D

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Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa

Chen

Cheng

Peng

et al. 2010

Chemistry & Biodiversity

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Bioassay-guided fractionation of the active AcOEt-soluble layer led to the isolation of two new pyranocoumarins, 3-hydroxyxanthyletin (1) and 3-methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)-(S)-marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumisoflavone (9) genistein (10), 2'-hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)-naringenin (15); three benzenoids, i.e., 4-hydroxybenzaldehyde (16), vanillin (17), and (S)-lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6beta-hydroxystigmast-4-en-3-one (20) and 6beta-hydroxystigmasta-4,22-dien-3-one (21), and a mixture of beta-sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses. Among these isolates, 3-hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)-naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H(37)R(V) in vitro with MIC values of 16, 35, 30, and < or =2.8 microg/ml, respectively.

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Constituents of Clinopodium Umbrosum

Cited by 12 publications

References 12 publications

Phenolic Compounds from Clinopodium urticifolium and Their Antivirus Activities

Phenolic Compounds from Clinopodium urticifolium and Their Antivirus Activities

Pterocarpan Derivatives from Clinopodium urticifolium and Their Cytotoxicity

Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa

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