Pterocarpan Derivatives from Clinopodium urticifolium and Their Cytotoxicity

Abstract

Clinopodium genus species are popular traditional Chinese medicinal herbs used to treat bruises and swelling and are also purported to improve blood circulation 1,2 . In recent years, several papers have described phytochemistry investigations of various species of clinopodium and it was found to be rich in saponins 3,4 , flavones 5,6 , polyphenols 7,8 , terpenes 9,10 , etc. Clinopodium urticifolium belongs to the Clinopodium genus, which widely distributed in Gansu, shaanxi, ningxia, in northwest China. In previous work, some bioactive compounds were isolated from this plant 8,11,12 . Motivated by a search for bioactive metabolites from this plant, a reinvestigation for the chemical constituents of the whole plant of C. urticifolium were carried out. As a result, a new pterocarpan (1), together with four known pterocarpan derivatives (2-5), were isolated from this plant. In addition, the cytotoxicity of compound 1 was evaluated. This work deals with the isolation, structural elucidation and biological activities of the new compound. EXPERIMENTALOptical rotations were measured with a Horiba SEPA-300 polarimeter. UV spectra were obtained using a Shimadzu UV-2401A spectrophotometer. CD spectra were measured on a JASCO J-810 spectropolarimeter. A Tenor 27 spectrophotometer was used for scanning IR spectroscopy with KBr pellets. 1D

α-Glucosidase Inhibition and Antibacterial Activity of Secondary Metabolites from the Ecuadorian Species Clinopodium taxifolium (Kunth) Govaerts

“…Several plants of the genus Clinopodium have been chemically investigated: flavonoids [ 5 ], other phenolics [ 6 ], caffeic acid oligomers [ 7 , 8 ], saponines and triterpenes [ 9 ] are common in these species. Metabolites like pterocarpanes [ 10 ] and lignans [ 9 ] are also known in some individuals.…”