Velucarpins A–C, three new pterocarpans and their cytotoxicity from the roots of Dalbergia velutina

Dalpulapans A–E from the roots of Dalbergia stipulacea

“…The extraction and isolation of hexane extract of the roots of D. stipulacea by chromatographic methods led to ve new compounds named dalpulapans A-E (1-5) (Fig. 1) and seven known compounds (6)(7)(8)(9)(10)(11)(12) including R,R-velucarpin A (6), 5 R,Rvelucarpin C (7), 5,6 taepeenin A (8), 7 taepeenin E (9), 7 pteroloterin A (10), 8 nortaepeenin A (11) 8 and 2-allyl-1,4dimethoxybenzene (12) (Fig. 1).…”

“…Kaennakam and coworkers reported the specific rotation of velucarpin A as [ α ] 20 D −83.8 and also showed negative Cotton effect at 247 (Δ ε −8.71). 5 Thus, the absolute configuration of compound 1 was 6a R ,11a R and it was named dalpulapan A.…”

A New Tocopherol Derivative and Cytotoxicity from the Leaves of Dalbergia velutina

“…Fraction A (5.0 g) was purified by silica gel CC eluted with 95% hexane-EtOAc (5 L) and further applied to a radial chromatography (chromatotron) with 80% hexane-CH 2 Cl 2 (200 mL) to afford compounds 1 (5. Cytotoxicity assay: All isolated compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were subjected to cytotoxic evaluation against KB (human epidermoid carcinoma), HeLa S-3 (human cervical carcinoma), HT29 (human colon adenocarcinoma), MCF-7(human breast adenocarcinoma) and HepG2 (human liver carcinoma) cell lines employing the colorimetric method [16]. Doxorubicin was used as the reference substance which exhibits activity against five cancer cell lines.…”

“…(Leguminosae), commonly known as " Khruea khang khwai " in Thailand, is a creeping plant mainly found in the northeastern region of Thailand. Previously, we reported the cytotoxicity of pterocarpans [1], isoflavones [2] and isoflavanes [3] from the roots of D. velutina. The interesting structures and diverse bioactivities prompted further investigation of the bioactive compounds from other parts of this plant.…”

Veluflavanones A–P, Cytotoxic Geranylated Flavanones from Dalbergia velutina Stems

“…Dalbergia velutina Benth (Leguminosae) is a plant found in Thailand, and the cytotoxicity of pterocarpans, isoflavones, and isoflavans from its roots has been reported previously. The discovery of compounds with interesting structures and diverse bioactivities prompted further investigations of bioactive compounds from other parts of the plant.…”