Dalpulapans A–E from the roots of Dalbergia stipulacea

Abstract

Five new compounds, dalpulapans A–E (1–5), were isolated from the hexane extract of the roots of Dalbergia stipulacea Roxb.

Structural modification of olibergin A, an isoflavonoid, from Dalbergia stipulacea Roxb. and its cytotoxicity

“…8 The chemical constituents from the stems and the roots of this plant are chalcones, isoflavonoids, flavonoids, pterocarpans, diterpenes and coumarins. 9–11 R , R -Velucarpin A, a pterocarpan, from the roots of this plant showed cytotoxicity against HeLa cells with an IC 50 value of 10.9 ± 0.42 μM (Posri et al , 2021). 9 (−)-12α-hydroxyrotenone from the methanol extract of D. stipulacea roots displayed cytotoxicity against HepG2 cell line with an IC 50 value of 18.01 ± 1.51 mM.…”

“…9–11 R , R -Velucarpin A, a pterocarpan, from the roots of this plant showed cytotoxicity against HeLa cells with an IC 50 value of 10.9 ± 0.42 μM (Posri et al , 2021). 9 (−)-12α-hydroxyrotenone from the methanol extract of D. stipulacea roots displayed cytotoxicity against HepG2 cell line with an IC 50 value of 18.01 ± 1.51 mM. 10 It was found that (−)-vestitol from the stems of this plant displayed the strongest antifungal activity against Pythium insidiosum and had higher activity than the amphotericin-B standard.…”