Constituents of Cultivated Mulberry Tree

Nomura, Taro; Fukai, Toshio; Hano, Yoshio; Nemoto, Katsumi; Terada, Shohei; Kuramochi, T.

doi:10.1055/s-2007-969975

Cited by 39 publications

(17 citation statements)

References 6 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[12] The plant is reported to contain the phytoconstituent tannins, phytosterols, sitosterols, saponins, triterpenes, flavanoids, benzofuran derivatives, morusimic acid, anthocyanins, anthroquinones, glycosides and oleanolic acid as the main active principles. [13–15]…”

Section: Introductionmentioning

confidence: 99%

Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves

Yadav¹,

Nade²

2008

Indian J Pharmacol

View full text Add to dashboard Cite

Objective:To evaluate the effect of methanolic extract of Morus alba L. leaves on dopaminergic function.Materials and Methods:The effect of the methanolic extract of Morus alba L. leaves was evaluated on haloperidol and metoclopramide induced catalepsy, foot shock-induced aggression, amphetamine-induced stereotyped behavior and phenobarbitone induced sleeping in mice. In each of these tests, the extract was administered in doses of 50, 100 and 200 mg/kg, i.p., 30 min before performing the test in mice. Further, the inhibitory effect of the extract on dopamine was studied using isolated rat vas deferens.Results:The extract produced significant dose dependent potentiation of haloperidol (1 mg/kg, i.p.) and metoclopramide (20 mg/kg, i.p.) induced catalepsy in mice. The extract significantly reduced number of fights and increased latency to fights in foot shock-induced aggression; it also decreased amphetamine (1 mg/kg, i.p.) induced stereotyped behavior in a dose dependent manner. The sleeping time induced by phenobarbitone (50 mg/kg, i.p.) too was prolonged. The extract inhibited contractions produced by dopamine on isolated rat vas deferens.Conclusion:The results suggest that the methanolic extract of Morus alba L. possesses antidopaminergic activity. Further neurochemical investigation can explore the mechanism of action of the plant drug with respect to antidopaminergic functions and help to establish the plant as an antipsychotic agent.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves

Yadav¹,

Nade²

2008

Indian J Pharmacol

View full text Add to dashboard Cite

show abstract

“…In the 1 H-NMR spectrum (CD 3 COCD 3 ), the proton signals of the methylcyclohexene ring were broadened, this phenomenon suggested that 1 existed as an equilibrium mixture of conformational isomers in solution, 3) and variable temperature studies were then carried out. Measured in DMSO-d 6 at 100°C, the 1 H-NMR spectrum of the methylcyclohexene ring was resolvable as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…1) Previously, many novel compounds, which were regarded biogenetically as Diels-Alder adducts of dehydroprenylphenols and chalcone derivatives, were isolated from M. alba, M. lhou, M. bombycis, and so on. [2][3][4][5][6][7][8] In the course of our seeking novel bioactive compound, we started phytochemical research on the stem bark of M. macroura. The EtOH extract of M. macroura was partitioned with CHCl 3 and EtOAc, and the EtOAc fraction was sequentially subjected to column chromatography over silica gel, silica gel RP-18 and Sephadex LH-20 to give six compounds.…”

mentioning

confidence: 99%

“…[2][3][4][5][6][7][8] In the course of our seeking novel bioactive compound, we started phytochemical research on the stem bark of M. macroura. The EtOH extract of M. macroura was partitioned with CHCl 3 and EtOAc, and the EtOAc fraction was sequentially subjected to column chromatography over silica gel, silica gel RP-18 and Sephadex LH-20 to give six compounds. The present paper deals with the isolation and structure elucidation of these compounds, as well as the evaluation of anti-oxidant effect of new compounds.…”

mentioning

confidence: 99%

See 1 more Smart Citation

New Diels-Alder Type Adducts from Morus macroura and Their Anti-oxidant Activities

Dai

Wang

et al. 2004

Chem. Pharm. Bull.

View full text Add to dashboard Cite

Fractionation of the ethanolic extract of the stem bark of Morus macroura resulted in the isolation of four new Diels-Alder type adducts, named guangsangons K-N (1, 2, 5, 6), together with two known compounds, mulberrofuran G (3) and K (4). Their structures were determined on the basis of spectroscopic analyses and chemical methods. Furthermore, by means of 1 H-NMR variable temperature experiments and the Cotton curves in the circular dichroism (CD) spectra, the stereochemistry of four new compounds was elucidated. The isolated new compounds showed good activity on anti-oxidant in vitro, with the inhibitory rates of MDA being from 91.8 to 100.0% at concentrations of 10 ؊5 mol/l.

show abstract

“…We reported the isolation and structure determination of a series of natural Diels-Alder adducts as well as of isoprenylated flavonoids isolated from the root barks of cultivated mulberry tree (1,2) and the Chinese crude drug "Sang-Bai-PI" (Japanese name "SOhakuhi") imported from the People's Republic of China (3). Some of the Diels-Alder adducts showed a significant hypotensive effect.…”

Section: Introductionmentioning

confidence: 99%