Components of Root Bark ofCudrania tricuspidatal.^1,2Structures of Four New Isoprenylated Xanthones, Cudraxanthones A, B, C and D

Abstract

Four new isoprenylated xanthones, cudraxanthones A, B and C were isolated from the N-hexane extract of the root bark of CUDRANIA TRICUSPIDATA (Carr.) Bur. (Japanese name "Hariguwa"; Moraceae), and cudraxanthone D from the benzene extract. The structures of cudraxanthones A, B, C and D were shown to be 1-4, respectively, on the basis of spectral and chemical evidence.

Hepatoprotective Compounds of the Roots of Cudrania tricuspidata on Tacrine-Induced Cytotoxicity in Hep G2 Cells

“…The structures of isolated compounds were identified as euchrestaflavanone C (1), 9) gerontoxanthone A (2), 10) cudraxanthone B (3), 11) cudraflavone B (4), 12) gericudranin E (5), 13) cudraxanthone C (7), 11) and cudraxanthone H (8), 14) respectively, by comparing UV, (Table 1), including one carbonyl group, two aromatic rings with six oxygenated carbons, and two C 5 groups, corresponding to a diprenylated and tetrahydroxylated xanthone. The positions of the substituents on the ring system were determined on the basis of HMBC correlations, as shown in Table 1.…”

Prenylated Xanthones from the Roots of Cudrania tricuspidata as Inhibitors of Lipopolysaccharide‐Stimulated Nitric Oxide Production

“…Additionally, the presence of two chromene rings was observed from the signals at [δ H 8.18 (1H, d, J = 10.4 Hz), 5.92 (1H, d, J = 10.0 Hz), 1.47 (6H, s); δ C 121.0, 132.3, 75.7, 26.3] and [δ H 6.57 (1H, d, J = 10.0 Hz), 5.87 (1H, d, J = 10.0 Hz), 1.50 (6H, s); δ C 121.6, 131.2, 77.5, 27.4], which were supported by HSQC and HMBC correlations. The position of one chromene ring was determined to be C‐1 from the HMBC correlations between H‐12 to C‐1 and H‐3 to C‐2 together with the downfielded proton signal of H‐11 at δ H 8.18 due to adjacent carbonyl group (C‐9) . The position of the other chromene ring was determined to be C‐7 from the HMBC correlations between H‐16 to C‐6, C‐8, and H‐17 to C‐7, which was supported by the NOESY correlation between H‐16 to H‐8.…”

“…Taken together, compound 29 was determined as shown and named cudracuspixanthone F. Compound 5, 27.4], which were supported by HSQC and HMBC correlations. The position of one chromene ring was determined to be C-1 from the HMBC correlations between H-12 to C-1 and H-3 to C-2 together with the downfielded proton signal of H-11 at d H 8.18 due to adjacent carbonyl group (C-9) [20]. The position of the other chromene ring was determined to be C-7 from the HMBC correlations between H-16 to C-6, C-8, and H-17 to C-7, which was supported by the NOESY correlation between H-16 to H-8.…”

Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells

“…In addition, the root bark and cortex of this species have been used in traditional medicine for the therapy of inflammation and neuritis [ 2 ]. Previous phytochemical research has shown that C. tricuspidata contains several components such as xanthones [ 3 ], flavonoids [ 4 ], and glycoproteins [ 5 ]. In recent studies of the pharmacological effects of this plant, C. tricuspidata extracts have been shown to have various biological effects, including hepatoprotective [ 6 ], antioxidant [ 7 ], monoamine oxidase-A inhibitory [ 8 ], neuroprotective [ 9 ], anti-atherosclerotic, and anti-inflammatory activities [ 10 ].…”