Constituent Properties of Licorices Derived from Glycyrrhiza uralensis, G. glabra, or G. inflata Identified by Genetic Information

Kondo, Kenji; Shiba, Mao; Nakamura, Rie; Morota, Takashi; Shoyama, Yukihiro

doi:10.1248/bpb.30.1271

Cited by 107 publications

(108 citation statements)

References 12 publications

(9 reference statements)

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“…As in previous studies on other plant species (Kim et al, 2012b;Li et al, 2012), most of the actinobacterial strains isolated from the liquorice species belonged to the genus Streptomyces. The composition of the antimicrobials produced by G. glabra differs from those produced by G. inflate (Kondo et al, 2007;Xie et al, 2010), plausibly influencing the different species compositions of the G. glabra and G. inflate associated culturable actinobacteria communities. Most of the Streptomyces species isolated from G. inflate and G. glabra, respectively, were grouped into separate clusters and represented a distinct phylogenetic branch.…”

Section: Discussionmentioning

confidence: 99%

“…However, as some bacteria may survive sterilization, for example, in plant tissue crevices or inside biofilms, we refer to our isolates as bacteria closely associated with plants. Since the bioactive compounds in G. glabra and G. inflate are different (Asl & Hosseinzadeh, 2008;Kondo et al, 2007;Xie et al, 2010), we hypothesized that the range of antimicrobial activity between isolates from the two liquorice species would be different.…”

Section: Introductionmentioning

confidence: 99%

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Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Zhao

Liao

et al. 2016

Microbiology

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A total of 218 actinobacteria strains were isolated from wild perennial liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza. inflate BAT. Based on morphological characteristics, 45 and 32 strains from G. inflate and G. glabra, respectively, were selected for further analyses. According to 16S rRNA sequence analysis, most of the strains belonged to genus Streptomyces and a few strains represented the rare actinobacteria Micromonospora, Rhodococcus and Tsukamurella. A total of 39 strains from G. inflate and 27 strains from G. glabra showed antimicrobial activity against at least one indicator organism. The range of the antimicrobial activity of the strains isolated from G. glabra and G. inflate was similar. A total of 34 strains from G. inflate and 29 strains from G. glabra carried at least one of the genes encoding polyketide synthases, non-ribosomal peptide synthetase and FADH 2 -dependent halogenase. In the type II polyketide synthase KSa gene phylogenetic analysis, the strains were divided into two major clades: one included known spore pigment production-linked KSa sequences and other sequences were linked to the production of different types of aromatic polyketide antibiotics. Based on the antimicrobial range, the isolates that carried different KSa types were not separated from each other or from the isolates that did not carry KSa. The incongruent phylogenies of 16S rRNA and KSa genes indicated that the KSa genes were possibly horizontally transferred. In all, the liquorice plants were a rich source of biocontrol agents that may produce novel bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Zhao

Liao

et al. 2016

Microbiology

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“…5) possessed higher potency for the neuroprotection at 10 lM concentration. This concentration is 3-50 times of those (0.014*0.246%) that were included in yokukansan (Hatano et al 1991;Sakakibara et al 1998;Ma et al 2005;Kondo et al 2007). The protective effect at lower concentrations was examined (0.001*0.1 lM), but no protection effect was observed in these concentrations.…”

Section: Discussionmentioning

confidence: 85%

Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan

2011

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Effects of a traditional Japanese medicine, yokukansan, which is composed of seven medicinal herbs, on glutamate-induced cell death were examined using primary cultured rat cortical neurons. Yokukansan (10-300 μg/ml) inhibited the 100 μM glutamate-induced neuronal death in a concentration-dependent manner. Among seven constituent herbs, higher potency of protection was found in Uncaria thorn (UT) and Glycyrrhiza root (GR). A similar neuroprotective effect was found in four components (geissoschizine methyl ether, hirsuteine, hirsutine, and rhynchophylline) in UT and four components (glycycoumarin, isoliquiritigenin, liquiritin, and 18β-glycyrrhetinic acid) in GR. In the NMDA receptor binding and receptor-linked Ca(2+) influx assays, only isoliquiritigenin bound to NMDA receptors and inhibited the glutamate-induced increase in Ca(2+) influx. Glycycoumarin and 18β-glycyrrhetinic acid bound to NMDA receptors, but did not inhibit the Ca(2+) influx. The four UT-derived components did not bind to NMDA receptors. The present results suggest that neuroprotective components (isoliquiritigenin, glycycoumarin, liquiritin, and 18β-glycyrrhetinic acid in GR and geissoschizine methyl ether, hirsuteine, hirsutine, and rhynchophylline in UT) are contained in yokukansan, and isoliquiritigenin, which is one of them, is a novel NMDA receptor antagonist.

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“…Their components are also similar with the genus glycyrrhiza. Many ‰avonoids and iso‰avones have already been identiˆed from genus glycyrrhiza (40,41,(48)(49)(50)(51)(52) or Glycine max. Among the components, glabrene was reported to be attributable to antimutagenic using Glycyrrhiza extract against EMS (53), and genistein showed antimutagenicity on MNU only at its high concentration (43z inhibition using 300 mg/plate of genistein toward 10 mg/plate of MNU) (54).…”

Section: Discussionmentioning

confidence: 99%

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

Tatsuzaki¹,

Yang²,

Kojo

et al. 2014

Genes and Environment

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N-Nitroso compounds are suspected to be causative agents for human cancer. N-Methyl-N-nitrosourea (MNU) is a typical direct acting mutagen with alkylation activity of DNA, and has been reported to be formed in vivo. Therefore, it is important for cancer chemoprevention toˆnd some compounds to inhibit mutagenicity induced by MNU. The inhibitory eŠect of plant extracts against the mutagenicity of MNU was evaluated using the Ames assay with Salmonella typhimurium TA1535. Among 43 extracts derived from medicinal and edible plant assayed, Glycyrrhiza aspera ethanolic extract, Glycine max extract with 40% iso‰avone aglycone (ISOMAX AG40) and Zingiber o‹cinale ethanolic extract at the range 0.01-1.0 mg/plate inhibited MNU-induced mutagenicity in S. typhimurium TA1535. No cytotoxicity of the three extracts were observed in Salmonella typhimuirum TA1535, indicating that inhibition of MNU-induced mutagenicity was apparently due to the antimutagenic potency of Glycyrrhiza aspera ethanolic extract, ISOMAX AG40 and Zingiber o‹cinale ethanolic extract. Therefore, the results of relative mutagenicity showed that Glycyrrhiza aspera ethanolic extract and ISOMAX AG40 decreased the mutagenic eŠects to 5.4% and 2.6%, respectively, whereas Zingiber o‹cinale ethanolic extract decreased it to 45%.

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Constituent Properties of Licorices Derived from Glycyrrhiza uralensis, G. glabra, or G. inflata Identified by Genetic Information

Cited by 107 publications

References 12 publications

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

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