“…Samples of exhaled air were collected at 15, 30, 45, 60, 90, 120, 150 and 180 minute intervals after lactulose ingestion. 4,[13][14][15][16][17] The no rebreathing valve set up device designed by QuinTron Instrument Company Inc. (Menomonee Falls, Wisconsin, USA) was used to collect exhaled air samples. The device has a valve that allows air to pass in one direction only.…”
Section: Methodsmentioning
confidence: 99%
“…Non-H 2 producers were considered as those patients who did not present a minimum elevation of 10 ppm H 2 in exhaled air after lactulose ingestion in any of the samples. [12][13][14][15][16][17] For the analysis of the results, the SigmaPlot 12.0 software (Systat Software Inc., USA) and Epi-Info version 6 (Centers for Disease Control and Prevention, USA) were used, using setting 5% as the level to reject the null hypothesis. The chisquare test was used for the analysis of categorical variables.…”
Section: Methodsmentioning
confidence: 99%
“…[2][3][4][5] It may also be found in functional gastrointestinal disorders such as irritable bowel syndrome, functional abdominal pain, and functional constipation. [6][7][8][9][10][11][12][13] SIBO is still associated with poverty and may favor nutrient malabsorption as part of environmental enteropathy. [14][15][16][17] Height impairment has been noted in children with SIBO living in underdeveloped countries when interpreting the concentrations of hydrogen (H 2 ) and methane (CH 4 ) in the lactulose breath test.…”
Section: Introductionmentioning
confidence: 99%
“…23 In our experience, lactulose was always used for SIBO research using the breath test. [13][14][15][16][17][18]22 In one of these articles 17 , both glucose and lactulose tests were performed, showing that H 2 production with glucose was very low, which presumably underestimated the prevalence of SIBO in the study population. 17 In this context, in another consensus published in 2017, it was recommended to use both lactulose and glucose as a substrate to be used in a study on SIBO using the breath test.…”
Objective: To evaluate the association between small intestinal bacterial overgrowth (SIBO) and weight and height impairment in children and adolescents with gastroenterology diseases. Methods: Observational and retrospective study. All 162 patients aged less than 19 years old who underwent breath test in search of SIBO between 2011 and 2016 were studied. Breath test was collected after the intake of 10 grams of lactulose. The concentration of hydrogen and methane was measured for 180 minutes after the beginning of the test by 12i QuinTronMicroLyzer device. Results: SIBO was identified in 51 (31.5%) patients. There was no difference between the age of those with (mean=8.7y.o; 25th and 75th percentile: 4.6 and 11.3) and without (mean=7.9y.o 25th and 75th percentile: 4.8 and 12.2) SIBO (p=0.910). There was no association between gender and SIBO (male 26.3% vs. female 36.3%, p=1.00). A lower median of height-for-age Z score (mean=-1.32; 25th and 75th percentile: -2.12 and -0.08 vs. mean=-0.59; 25th and 75th percentile: -1.57 and 0.22; p=0.04) was demonstrated in children with SIBO when compared with children without it. There was no difference between the BMI-for-age Z score of patients with (mean=-0.48) and without SIBO (mean=-0.06) (p=0.106). The BMI of patients with SIBO (median=15.39) was lower than of those without it (median=16.06); however, the statistical analysis was not significant (p=0.052). The weight-for-age Z score was lower in patients with SIBO (mean=-0.96) than in those without SIBO (mean=-0.22) (p=0.02) Conclusions: Children and adolescents with SBIO associated with diseases of the gastrointestinal tract have lower weight and height values.
“…Samples of exhaled air were collected at 15, 30, 45, 60, 90, 120, 150 and 180 minute intervals after lactulose ingestion. 4,[13][14][15][16][17] The no rebreathing valve set up device designed by QuinTron Instrument Company Inc. (Menomonee Falls, Wisconsin, USA) was used to collect exhaled air samples. The device has a valve that allows air to pass in one direction only.…”
Section: Methodsmentioning
confidence: 99%
“…Non-H 2 producers were considered as those patients who did not present a minimum elevation of 10 ppm H 2 in exhaled air after lactulose ingestion in any of the samples. [12][13][14][15][16][17] For the analysis of the results, the SigmaPlot 12.0 software (Systat Software Inc., USA) and Epi-Info version 6 (Centers for Disease Control and Prevention, USA) were used, using setting 5% as the level to reject the null hypothesis. The chisquare test was used for the analysis of categorical variables.…”
Section: Methodsmentioning
confidence: 99%
“…[2][3][4][5] It may also be found in functional gastrointestinal disorders such as irritable bowel syndrome, functional abdominal pain, and functional constipation. [6][7][8][9][10][11][12][13] SIBO is still associated with poverty and may favor nutrient malabsorption as part of environmental enteropathy. [14][15][16][17] Height impairment has been noted in children with SIBO living in underdeveloped countries when interpreting the concentrations of hydrogen (H 2 ) and methane (CH 4 ) in the lactulose breath test.…”
Section: Introductionmentioning
confidence: 99%
“…23 In our experience, lactulose was always used for SIBO research using the breath test. [13][14][15][16][17][18]22 In one of these articles 17 , both glucose and lactulose tests were performed, showing that H 2 production with glucose was very low, which presumably underestimated the prevalence of SIBO in the study population. 17 In this context, in another consensus published in 2017, it was recommended to use both lactulose and glucose as a substrate to be used in a study on SIBO using the breath test.…”
Objective: To evaluate the association between small intestinal bacterial overgrowth (SIBO) and weight and height impairment in children and adolescents with gastroenterology diseases. Methods: Observational and retrospective study. All 162 patients aged less than 19 years old who underwent breath test in search of SIBO between 2011 and 2016 were studied. Breath test was collected after the intake of 10 grams of lactulose. The concentration of hydrogen and methane was measured for 180 minutes after the beginning of the test by 12i QuinTronMicroLyzer device. Results: SIBO was identified in 51 (31.5%) patients. There was no difference between the age of those with (mean=8.7y.o; 25th and 75th percentile: 4.6 and 11.3) and without (mean=7.9y.o 25th and 75th percentile: 4.8 and 12.2) SIBO (p=0.910). There was no association between gender and SIBO (male 26.3% vs. female 36.3%, p=1.00). A lower median of height-for-age Z score (mean=-1.32; 25th and 75th percentile: -2.12 and -0.08 vs. mean=-0.59; 25th and 75th percentile: -1.57 and 0.22; p=0.04) was demonstrated in children with SIBO when compared with children without it. There was no difference between the BMI-for-age Z score of patients with (mean=-0.48) and without SIBO (mean=-0.06) (p=0.106). The BMI of patients with SIBO (median=15.39) was lower than of those without it (median=16.06); however, the statistical analysis was not significant (p=0.052). The weight-for-age Z score was lower in patients with SIBO (mean=-0.96) than in those without SIBO (mean=-0.22) (p=0.02) Conclusions: Children and adolescents with SBIO associated with diseases of the gastrointestinal tract have lower weight and height values.
“…(JPGN 2013;57: 316-318) S mall intestinal bacterial overgrowth (SIBO) is an intestinal microflora imbalance with abnormally high bacterial counts in the small intestine, which may be associated with a wide clinical spectrum ranging from the absence of clinical features or mild and unspecific intestinal symptoms to severe malabsorption (1,2). SIBO may be associated with diverse clinical conditions, such as chronic diarrhea (3,4), malnutrition (5), intestinal failure (2,(6)(7)(8), and functional gastrointestinal disorders (9)(10)(11)(12), and with children living in areas with poor sanitation, such as in urban slums (13,14).…”
Trimethoprim-sulfamethoxazole and metronidazole were used for 14 days to treat 20 children with small intestine bacterial overgrowth (SIBO). SIBO was diagnosed using the lactulose hydrogen breath test. The breath test was repeated 1 month after treatment, and 19 (95.0%) of 20 children showed no evidence of SIBO (P < 0.001). The area under the individual curves showed that children with SIBO exhibited greater hydrogen production before treatment in both the first hour and between 60 and 180 minutes after the breath test. The treatment did not decrease methane production. In conclusion, trimethoprim-sulfamethoxazole and metronidazole was effective in treating children with SIBO.
Important differences were observed between the gut microbiota of children living under distinct socioeconomic and environmental conditions within the same city. Our findings suggest that children of high socioeconomic status have less favorable gut microbiota than do children who live in poverty.
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