Consanguineous Marriage in Jordan: An Update

Islam, M. Mazharul; Ababneh, Faisal; Khan, Hasinur Rahaman

doi:10.1017/s0021932017000372

Cited by 34 publications

(26 citation statements)

References 10 publications

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“…Consanguinity rates in the ME are significantly higher than in developed countries and are largely influenced by cultural and religious factors (Tadmouri et al, 2009). Studies have documented that these rates are decreasing by generation (Sirdah, 2014, Islam et al, 2018), including among Palestinians: 45.2% in the previous parental generation and 39.9% in the current generation (Sirdah, 2014). This decline is linked to higher education among women, declining fertility, resulting in fewer suitable marriageable relatives, greater mobility from rural to urban settings, and improved economic status of families (Tadmouri et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Consanguinity on Familial Clefting Among Palestinians

Saeed

Moore

Zawahrah

et al. 2019

The Cleft Palate-Craniofacial Journal

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Introduction: Orofacial clefts (OFC) are the most common congenital craniofacial anomaly. The relationship between intermarriage (consanguinity) and positive family history for OFC is not well described. Consanguinity rates in developed countries are <1% but are considerably higher in the Middle East (45%). Familial clefting rates in developed countries are under 20% but in the Middle East are reported at 30% or higher. Objective: To determine OFC demographics and to clarify the relationship between consanguinity and familial clefting among Palestinians. Design: The Palestinian Congenial Anomalies Database is based on a 700-question survey administered to mothers of children with congenital anomalies. Orofacial clefts were diagnosed in 540 children. All demographic data were analyzed using χ2 tests with a level of significance at α < .05. Results: Demographics for OFC among Palestinians were similar to other published reports. Overall consanguinity rate was 53% and familial clefting rate was 49%. Parental rates of consanguinity were significantly different for patients with cleft palate. Patients with consanguineous parents had a higher rate of positive family history of clefting (67%). Recurrence of clefts in siblings was significantly higher among those born to consanguineous parents (73%) when compared to nonconsanguineous parents. Conclusion: Consanguinity rates for Palestinians with OFC were higher than those reported in the Middle East. Familial clefting and sibling recurrence rates were also higher than expected. The risk of OFC may be mitigated with improved education about anticipated genetic consequences of consanguinity in high-risk populations such as the southern West Bank.

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Section: Discussionmentioning

confidence: 99%

The Influence of Consanguinity on Familial Clefting Among Palestinians

Saeed

Moore

Zawahrah

et al. 2019

The Cleft Palate-Craniofacial Journal

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“…Population and Family Health Surveys (2012), 35% of all marriages were consanguineous in Jordan, and most of those were first-cousin marriages (66%). 22 However, the previous study in Jordan found no association between parental consanguinity and recurrent seizures. 9 This discrepancy might be explained by differences in study design, sampling, and settings.…”

Section: Discussionmentioning

confidence: 91%

“…21 Jordan has a high prevalence of consanguineous marriages. 22 In addition, social traditions, levels of education, and place of residence all play important roles in the rates of consanguineous marriage. 22,23 According to Jordan…”

Section: Discussionmentioning

confidence: 99%

Recurrence of First Afebrile Unprovoked Seizure and Parental Consanguinity: A Hospital-Based Study

et al. 2020

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Purpose: The aim of the current study was to determine the incidence, clinical characteristics, and risk factors associated with the recurrence of first unprovoked seizure in children. Methods: A retrospective, observational study was conducted at King Abdullah University Hospital in Jordan. Children aged from 1 month to 16 years old who attended the hospital between January 2013 to December 2017 were evaluated on the basis of medical records, from the first visit and for a 1-year follow-up period. Results: During the study period, a total of 290 cases with first unprovoked seizure were included. The incidence of first unprovoked seizure was 441 cases per 100 000 patient visits to the pediatric clinic. More than half of the cases developed a second attack (55.3%). Children with parental consanguinity were almost 3 times more likely to develop a second attack of seizure compared to those without parental consanguinity (odds ratio [OR] = 2.785, 95% confidence interval [CI] = 1.216-6.378, P = .015) and patients who had a history of focal type of seizure were almost twice as likely to develop seizure recurrence (OR = 1.798, 95% CI = 1.013-3.193, P = .045). Conclusions: The current results showed a high incidence of first unprovoked seizure among children in Jordan. Parental consanguinity and focal seizure were associated with the increased risk of recurrent attack. This finding highlights the need for public education regarding the outcomes of parental consanguinity to improve the patient’s quality of life.

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“…The rate is still considerably high. [13] Several regionally oriented research studies have reported a high consanguinity rate as a significant contributor to congenital, hereditary, and genetic renal diseases, [11,16,18] as opposed to researches in Western countries. [2,3,12] The third most common renal disease reported in the current research was a CRF.…”

Section: Discussionmentioning

confidence: 99%

“…[7,12] Understanding the spectrum of renal diseases and identifying contributing factors will promote early diagnosis and facilitate treatment. [2,3] In Jordan, local circumstances such as high consanguinity level, [13] low income, large families, parents' level of education, and residential location play a crucial role in the spectrum and are contributing factors that lead to the development of numerous childhood renal diseases. [14] Recently, there is an increase in the amount of existing data on renal diseases in children.…”

Section: Introductionmentioning

confidence: 99%

Spectrum and contributing factors of renal diseases among Jordanian children

Alkadomi

Shawish

Saleh

et al. 2019

CNS

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Renal diseases are a significant cause of morbidity and mortality in children. They can affect children in various ways: they vary from completely treatable without long-lasting consequences to severe disorders such as chronic kidney disease. The causes of renal disease may differ from one country to another. Understanding the spectrum and identifying the contributing factors of renal diseases in a specific country promote early diagnosis, facilitate treatment, and prevent complications such as renal failure and end-stage kidney disease. This study was conducted to establish the spectrum and contributing factors to renal diseases among Jordanian children receiving health care in a tertiary hospital in Amman, Jordan (Prince Hamza Hospital). A convenience sample of 129 children diagnosed with renal diseases, treated and followed in our nephrology clinic, were interviewed during 2015 to 2017. A kidney-disease patient questionnaire was used to interview the children or their caregivers. The study revealed that the most common renal disease among the participants was urinary tract infection (UTI, 35.7%), followed by congenital diseases (34.1%), then chronic renal failure (CRF, 11.6%). There were several contributing factors of renal disease among the studied children, such as malnutrition, poverty, high rate of consanguinity, delayed diagnosis, and geographical location.

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Consanguineous Marriage in Jordan: An Update

Cited by 34 publications

References 10 publications

The Influence of Consanguinity on Familial Clefting Among Palestinians

The Influence of Consanguinity on Familial Clefting Among Palestinians

Recurrence of First Afebrile Unprovoked Seizure and Parental Consanguinity: A Hospital-Based Study

Spectrum and contributing factors of renal diseases among Jordanian children

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