The Influence of Consanguinity on Familial Clefting Among Palestinians

Saeed, Omar Babar; Moore, Meredith G.; Zawahrah, Hassan J; Tayem, Moath; Kavoosi, Tazheh; Aalst, John A. van

doi:10.1177/1055665619838381

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…Rajeev et al 35 found that parental consanguinity was significantly associated with CP ( P = 0.04), but not with cleft lip with or without cleft palate. Similar conclusion was reported by Sabbagh et al 30 and Saeed et al 31 On the other hand Leite and Koifman 36 found parental consanguinity was associated only with CL/P (OR = 3.8, 1.27–12.18).…”

Section: Discussionsupporting

confidence: 87%

“…Although all types of OFCs had positive correlation with parental consanguinity, the relationship was only statistically significant for the CP type, with a doubling of the risk, particularly for first cousin marriages 30 . This finding was close to the frequency of consanguineous marriage among OFCs sample of Palestinian population, where they found a frequency of 53% of parental consanguinity 31 . It is worth noting that Jordanian, Saudi Arabian, and Palestinian populations are all of Arab ethnicity, an ethnicity that is known for its genetic heterogeneity, which might explain some of the variation found between discussed studies 32 …”

Section: Discussionsupporting

confidence: 51%

“…30 This finding was close to the frequency of consanguineous marriage among OFCs sample of Palestinian population, where they found a frequency of 53% of parental consanguinity. 31 It is worth noting that Jordanian, Saudi Arabian, and Palestinian populations are all of Arab ethnicity, an ethnicity that is known for its genetic heterogeneity, which might explain some of the variation found between discussed studies. 32 Two recent case-control studies, 1 from Pakistan and the other from Iran, both showed a positive correlation between, paternal consanguinity and OFCs, with an OR of 1.79 (95% CI, 1.13-2.85) and (OR ¼ 1.926; CI 1.393-2.662), respectively.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Parental Consanguinity on the Frequency of Orofacial Clefts in Jordan

Jabaiti¹,

Salah²,

Al-lawama³

et al. 2021

Journal of Craniofacial Surgery

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Orofacial clefts (OFCs) are the most common craniofacial congenital anomalies, and its prevalence is highest among Asian populations. The aim of this retrospective case-control study is to evaluate the effect of parental consanguinity on the frequency of OFCs at Jordan University Hospital over a 15-year-period. The study group consists of all patients with OFCs presented to the major tertiary referral center in Jordan during the last 15 years, along with age and gender-matched controls. The authors analyzed the risk of different predictors, including consanguinity, on the development of OFCs, both cleft lip with or without cleft palate (CL/P) and cleft palate only. A total of 332 participants were included in this study, with a mean age of 74.36 (AE48.75) months. The authors included 129 (38.9%) OFCs, and 203 (61.1%) controls. The percentage of parental consanguinity among OFCs group was 41.1%, compared to only 24.1% for controls, a difference that was statistically significant (P ¼ 0.001). On logistic regression analysis, the authors found that parental consanguinity is a significant predictor for the occurrence of OFCs (P ¼ 0.007), where people with consanguineous marriage have 2 times higher risk (odds ratio of 0.504, with 95% confidence interval 0.306-0.830) to have offspring with OFCs. Moreover, lower birth weight babies are also significantly more associated with OFCs (P ¼ 0.014), with an odds ratio of 1.819 (95% confidence interval 1.131 2.926). Among the Jordanian population, the authors found that consanguinity and lower birth weight were the only variables significantly associated with the development of OFCs.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Impact of Parental Consanguinity on the Frequency of Orofacial Clefts in Jordan

Jabaiti¹,

Salah²,

Al-lawama³

et al. 2021

Journal of Craniofacial Surgery

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“…13 According to research conducted in India, left-sided unilateral NS CL/P clefts in children were more prevalent than their right-sided counterparts. 14 Given that the right-sided fetal head arteries leave the aortic arch closer to the heart, it has been hypothesized that the right side may have a better hemodynamic perfusion. One of the risk factors for NS CB/P diseases is consanguinity.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate

Rochmah,

Harumsari,

Christiono

et al. 2023

Eur J Dent

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Objectives The etiologies of nonsyndromic cleft lips with or without palate (NS CL/P) are multifactorial, which include consanguineous marriages. The incidence of NS CL/P is relatively high in Indonesia notably in one of Indonesia's tribes whose members frequently marry close cousins. Thus, the purpose of this study is to analysis consanguinity as risk factor of NS CL/P in Sasak tribe, East Lombok, Indonesia Materials and Methods An observational analysis was made of a collected database of NS CL/P patients treated in social services in regency hospital of Dr. Soejono Selong, East Lombok, Indonesia. Demographic data such as age, gender, address (urban/rural), parent's education, presence or absence of consanguinity, type of clefts, and a three-generation pedigree were collected by interview and hospital medical record. Before analysis, patient information was anonymized and deidentified. From 2016 to 2018, each of 100 cleft and normal subjects with their Sasak parent were audited. The risk factors were analyzed statistically using odds ratio (OR) and chi-squared test. Results Consanguineous marriages identified 54 cases (54%), and 10 cases (10%) out of a total each 100 NS CL/P and controls, respectively. The majority of consanguinity (53.7%) was discovered in marriages between first cousins. NS CL/P cases were statistically linked (p = 0.00) with consanguineous marriages (OR: 10; 95% confidence interval: 1.6–3.1); in which the most prevalent case is unilateral cleft lips. Conclusion Consanguineous marriage increases the risk of NS CL/P in Sasak tribe, East Lombok, Indonesia. The development of strategies to educate communities on the impacts of culture-consanguineous marriage is required. The genetic inheritance from their ancestor may be responsible for the increased incidence of NS CL/P.

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“…El paladar hendido y labio leporino son las malformaciones congénitas más comunes de la cabeza y cuello en Irán. En un estudio realizado en 2017, se encontró que el matrimonio consanguíneo se asocia fuertemente (OR=3,2; IC95%:1,9-5,3) con una mayor incidencia de esta anomalía [34], en tanto que en Palestina se encontró que en los pacientes con paladar hendido la tasa de consanguinidad era del 67% [35].…”

Section: Anomalías Congénitas Y Patologías Asociadas a Consanguinidadunclassified

La endogamia como causa de consanguinidad y su asociación con anomalías congénitas

et al. 2020

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El papel de la endogamia como causa de homocigosidad en la salud humana es un foco de interés en genética médica, debido a su relación con anomalías congénitas y patologías genéticas recesivas. Es un tema importante a pesar de que las tasas de uniones consanguíneas en ciertas sociedades han disminuido con el tiempo; sin embargo, en algunas comunidades se han mantenido estables o han aumentado. La consanguinidad es practicada hasta en el 10% de la población mundial, y los motivos más comúnmente citados son socioculturales y socioeconómicos. Aunque se ha visto una disminución de esta práctica, probablemente por la migración urbana y el aumento de las tasas de educación, la consanguinidad continúa practicándose en todo el mundo. Los efectos más significativos sobre los resultados reproductivos se deben, principalmente, a condiciones hereditarias autosómicas recesivas, que también aumentan la frecuencia de algunos desórdenes médicos. El objetivo de esta revisión es dar a conocer la epidemiología y los factores predisponentes de la consanguinidad, así como presentar la evidencia actual de la asociación entre la consanguinidad originada en la endogamia y las anormalidades congénitas y patologías médicas como consecuencia de trastornos genéticos mendelianos. Se requiere un enfoque culturalmente apropiado para el asesoramiento genético en relación con la endogamia.

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The Influence of Consanguinity on Familial Clefting Among Palestinians

Cited by 10 publications

References 41 publications

Impact of Parental Consanguinity on the Frequency of Orofacial Clefts in Jordan

Impact of Parental Consanguinity on the Frequency of Orofacial Clefts in Jordan

Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate

La endogamia como causa de consanguinidad y su asociación con anomalías congénitas

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