Connaissances et comportements de 50 familles congolaises concernées par la drépanocytose: une enquête locale

Mbiya, Benoît Mukinayi; Kalenda, Didier Kalombo; Mbelu, Stéphanie; Gulbis, Béatrice

doi:10.11604/pamj.2018.29.24.12276

Cited by 16 publications

(15 citation statements)

References 12 publications

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“…The results of the first year of follow-up showed that sickle cell children without any specific medical intervention presented severe clinical and hematological pictures with an annual average of four VOCs, four infectious episodes, one acute thoracic syndrome, and four hospitalizations, demonstrating the severity of the disease in a remote area of a developing country. Annual averages of acute events and degradation of biological parameters similar to the results of this study among SCD patients who have not been followed-up with in the past have been reported in the literature [47,50,[53][54][55]; however, there were no reports on the impact of regular follow-ups in those studies.…”

Section: Discussionsupporting

confidence: 84%

Improvement of Sickle Cell Disease Morbimortality in Children: Experience in a Remote Area of an African Country

Mbiya¹,

Kalombo²,

Mukendi³

et al. 2020

Preprint

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Background: Sickle cell disease (SCD) is a public health problem in the Democratic Republic of Congo. While reference sickle cell centers have been implemented in capital cities of African countries and have proven to be beneficial for SCD patients, they have never been set up in rural areas for families with very low sources of income. Method: A cohort of 143 children with SCD aged 10 years old (IQR (interquartile range): 6–15 years) (sex ratio male/female = 1.3) were clinically followed for 12 months without any specific intervention aside from the management of acute events, and then for 12 months with a monthly medical visit, biological follow-up, and regular prophylaxis. Results: The median age of patients at the diagnosis of SCD was 2 years (IQR: 1–5). The implementation of standardized and regular follow-ups in a new sickle cell referral center in a remote city showed an increase in the annual mean hemoglobin level from 50 to 70 g/L (p = 0.001), and a decrease in the lymphocyte count and spleen size (p < 0.001). A significant decrease (p < 0.001) in the average annual number of hospitalizations and episodes of vaso-occlusive crises, blood transfusions, infections, and acute chest syndromes were also observed. Conclusions: Creation of a sickle cell referral center and the regular follow-up of children with SCD are possible and applicable in the context of a remote city of an African country and represent simple and accessible measures that can reduce the morbimortality of children with sickle cell disease.

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Section: Discussionsupporting

confidence: 84%

Improvement of Sickle Cell Disease Morbimortality in Children: Experience in a Remote Area of an African Country

Mbiya¹,

Kalombo²,

Mukendi³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The results of the first year of follow-up showed that sickle cell children without any specific medical intervention presented severe clinical and hematological pictures with an annual average of 4 VOCs, 4 infectious episodes, 1 acute thoracic syndrome, 4 hospitalizations demonstrating the severity of the disease in a remote area of a developing country. Annual averages of acute events and degradation of biological parameters similar to the results of this study among SCD patients who have not been followed-up in the past were reported in the literature [47,50,[53][54][55]; however, those studies did not report the impact of a regular follow-up.…”

Section: Discussionsupporting

confidence: 83%

Improvement of Sickle Cell Disease Morbi-Mortality in Children: Experience Gained in a Remote Area of an African Country

Mbiya¹,

Kalombo²,

Mukendi³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Sickle cell disease (SCD) is a public health problem in the Democratic Republic of Congo. If reference sickle cell centers have been implemented in capital-cities of African countries and have proven to be beneficial for SCD patients, it has never been set up ina rural area for families with very low sources of income. Method: A cohort of 143 children with SCD aged 10 years old (IQR [inter quartile range]: 6–15 years) (sex ratio male: female = 1.3) were clinically followed for 12 months without any specific intervention, outside management of acute events ,and then 12 months with a monthly medical visit , a biological follow-up and regular prophylaxis. Results: The median age of patients at the diagnosis of SCD was 2 years (IQR: 1–5). The implementation of standardized and regular follow-up in a new sickle cell referral center in a remote city showed an increase in the annual mean hemoglobin level from 50 to 70 g/L (p = 0.001), and a decrease of the lymphocytes count and spleen size (p < 0.001). A significant decrease (p < 0.001) in the average annual number of hospitalizations and episodes of vaso-occlusive crises, blood transfusions, infections, and acute chest syndromes were also observed. Conclusions: Creation of a sickle cell referral center and a regular follow-up of children with SCD are possible and applicable in the context of a remote city of an African country. Those simple and accessible measures can reduce the morbimortality of the sickle cell children.

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“…Mais en rapport avec le sexe, les études sont contradictoires. Certaines montrent une prédominance masculine [28, 29]; d'autres une prédominance féminine [29-32]; d'autres encore une répartition égale entre les 2 sexes [33, 34]. Nous pensons que la prédominance de l'un ou l'autre genre est le fait du hasard.…”

Section: Discussionunclassified

Pathologies digestives associ�es � la dr�panocytose � Lubumbashi: aspects �pid�miologiques et cliniques

Banza¹,

Mulefu²,

Lire³

et al. 2019

Pan Afr Med J

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Introductionla drépanocytose est une maladie génétique de transmission autosomique liée à une anomalie de structure de l'hémoglobine qui aboutit à la formation de l'hémoglobine S. Le but de notre étude est de colliger les cas de pathologies digestives rencontrées chez les drépanocytaires de Lubumbashi et d'en ressortir les caractéristiques épidémiologiques et cliniques.Méthodesil s'agit d'une étude rétrospective, descriptive transversale réalisée au Centre de Recherche de la Drépanocytose de Lubumbashi. Elle a concerné les dossiers des patients suivi pour drépanocytose ayant présenté une pathologie digestive au cours de notre période de 3 ans (de janvier 2015 à décembre 2017). Le recueil des données s'est fait grâce à une fiche d'enquête comportant différents paramètres d'étude comprenant: l'âge, le sexe, le motif de consultation, le diagnostic, le type de crise vaso-occlusive, les examens paracliniques réalisés, le traitement à l'hydroxyurée.Résultatsnous avons colligé 206 dossiers (N=206) des patients drépanocytaires ayant fait une pathologie digestive sur un total de 403 dossiers examinés, ce qui représente une fréquence de 51,11% des pathologies digestives chez les drépanocytaires. Les 2 sexes sont représentés avec une légère prédominance féminine (51,94%) et un sexe ratio H/F: 0,92. La tranche d'âge la plus représentée est celle comprise entre 1 et 6 ans (32,52%), la moyenne d'âge: 11,8ans; écart-type: 21,9; âges extrêmes: 13 mois et 38 ans. Le motif de consultation est dominé par la fièvre (60,67%), la douleur abdominale (44,66%) et les troubles digestifs (30,09%). Les crises vaso-occlusives abdominales sont retrouvées chez 65 patients (31,55%) parmi lesquels 36 patients ont présenté 1 seule crise, 24 en ont présenté 2 et 5 patients en ont présenté 3. Les pathologies intestinales étaient présentes chez 121 patients (69,41%) dominées par la parasitose intestinale (retrouvée chez 58 patients dont l'examen des selles a mis en évidence 4 parasites: le Yersinia enterocolitis, l'entamoeba histolytica, le Giardia intestinalis et le clostridium difficile); les pathologies gastriques retrouvées chez 105 patients (50,97%) reparties en ulcère gastro-duodénal (45 patients) et gastrite (60 patients); la pathologie vésiculo-biliaire présente chez 40 patients (19,41%) comprenant la lithiase vésiculaire sans cholécystite 32 patients, la cholécystite lithiasique 5 patients et 3 cas de lithiase de la voie biliaire principale; 1 seul cas de pancréatite aigue diagnostiquée. Les pathologies associées les plus retrouvées dans notre étude sont respiratoires avec 169 cas (82,03%), oto-rhino-laryngologiques avec 157 cas (76,21%), les crises vaso-occlusives osseuses (146 cas soit 70,87%), pathologies uro-génitales avec 64 cas (31,06%) et le paludisme chez 51 patients (24,75%). Les atteintes spléniques et hépatiques ont constitué chacun 47 cas (22,81%) et 18 cas (8,73%). L'échographie a était demandé chez 79 patients mais seulement 31 d'entre-eux l'ont réalisé, faute de moyen financier car il coute sur place 20 dollars américains. En ...

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Connaissances et comportements de 50 familles congolaises concernées par la drépanocytose: une enquête locale

Cited by 16 publications

References 12 publications

Improvement of Sickle Cell Disease Morbimortality in Children: Experience in a Remote Area of an African Country

Improvement of Sickle Cell Disease Morbimortality in Children: Experience in a Remote Area of an African Country

Improvement of Sickle Cell Disease Morbi-Mortality in Children: Experience Gained in a Remote Area of an African Country

Pathologies digestives associ�es � la dr�panocytose � Lubumbashi: aspects �pid�miologiques et cliniques

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