Conjugates and nano-delivery of antimicrobial peptides for enhancing therapeutic activity

Faya, Mbuso; Kalhapure, Rahul S.; Kumalo, Hezekiel M.; Waddad, Ayman Y.; Omolo, Calvin A.; Govender, Thirumala

doi:10.1016/j.jddst.2017.12.010

Cited by 38 publications

(24 citation statements)

References 190 publications

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“…Nanotechnology has revolutionized the use of bacteriocins not only as food additives but also for pharmaceutical use. Carbohydrate nanoparticles (Bi, Yang, Bhunia, & Yao, ) and gold nanoparticles (Thirumurugan, Ramachandran, & Shiamala, ; Mossallam, Amer, & Diab, ) functionalization with LAB‐bacteriocins showed enhanced antibacterial effect, shelf life extension, and also delivery efficacy; this last characteristic could improve the use of bacteriocins as therapeutic agents to be used in the treatment of microbial infections (Faya et al., ).…”

Section: Bacteriocins: Technological Applicationmentioning

confidence: 99%

Production of Bioactive Peptides from Lactic Acid Bacteria: A Sustainable Approach for Healthier Foods

Venegas-Ortega

Flores‐Gallegos

Martínez-Hernández

et al. 2019

Comp Rev Food Sci Food Safe

100

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Traditional fermented foods where lactic acid bacteria (LAB) are present have been associated with beneficial effects on human health, and some of those benefits are related to protein‐derived products. Peptides produced by LAB have attracted the interest of food industries because of their diverse applications. These peptides include ribosomally produced (bacteriocins) and protein hydrolysates by‐products (bioactive peptides), which can participate as natural preservatives and nutraceuticals, respectively. It is essential to understand the biochemical pathways and the effect of growth conditions for the production of bioactive peptides and bacteriocins by LAB, in order to suggest strategies for optimization. LAB is an important food‐grade expression system that can be used in the simultaneous production of peptide‐based products for the food, animal, cosmetic, and pharmaceutical industries. This review describes the multifunctional proteinaceous compounds generated by LAB metabolism and discusses a strategy to use a single‐step production process, using an alternative protein‐based media. This strategy will provide economic advantages in fermentation processes and will also provide an environmental alternative to industrial waste valorization. New technologies that can be used to improve production and bioactivity of LAB‐derived peptides are also analyzed.

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Section: Bacteriocins: Technological Applicationmentioning

confidence: 99%

Production of Bioactive Peptides from Lactic Acid Bacteria: A Sustainable Approach for Healthier Foods

Venegas-Ortega

Flores‐Gallegos

Martínez-Hernández

et al. 2019

Comp Rev Food Sci Food Safe

100

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“…The use of biodegradable/biocompatible polymers in biomedicine and the food industry has increased in the last decades. During 2017–2018, some review articles, including state-of-the-art polymer-based strategies to improve in vivo biocompatibility and delivery systems for AMPs, were published [10,46,47]. Furthermore, in the following paragraphs, we gather an update on the most recently published works reporting the use of polymer nanoparticles [48,49,50], nanofibers [51,52], multilayers [53,54], polymer-coated surfaces [55,56], and polymer conjugates [57,58,59,60,61,62,63] for AMP delivery.…”

Section: Organic Nanosystemsmentioning

confidence: 99%

“…For all that, encapsulation of AMPs into liposomes is a desirable strategy to prevent the drawbacks associated with the direct application of these AMPs, since cytotoxicity could be decreased and stability and bioactivity enhanced [85]. Thus, the number of publications researching the antimicrobial activity of AMPs encapsulated in liposomes, in fields such as food technology [86,87,88] and biomedicine [47,85,89], has risen during the last few years (Table 4).…”

Section: Organic Nanosystemsmentioning

confidence: 99%

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2019

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Recently, antimicrobial peptides (AMPs), also called host defence peptides (HDPs), are attracting great interest, as they are a highly viable alternative in the search of new approaches to the resistance presented by bacteria against antibiotics in infectious diseases. However, due to their nature, they present a series of disadvantages such as low bioavailability, easy degradability by proteases, or low solubility, among others, which limits their use as antimicrobial agents. For all these reasons, the use of vehicles for the delivery of AMPs, such as polymers, nanoparticles, micelles, carbon nanotubes, dendrimers, and other types of systems, allows the use of AMPs as a real alternative to treatment with antibiotics.

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“…Other major requirement in AMPs containing assemblies has been the sustained release for improving bioactivity such the delivery of lipopeptides from biodegradable polymeric carriers against oral pathogens [ 216 ]. The novel approaches for delivering AMPs have been recently and extensively reviewed in excellent articles [ 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 ].…”

Section: Bsa With Peptidesmentioning

confidence: 99%

Self-Assembled Antimicrobial Nanomaterials

Carmona-Ribeiro

2018

IJERPH

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Nanotechnology came to stay improving the quality of human life by reducing environmental contamination of earth and water with pathogens. This review discusses how self-assembled antimicrobial nanomaterials can contribute to maintain humans, their water and their environment inside safe boundaries to human life even though some of these nanomaterials display an overt toxicity. At the core of their strategic use, the self-assembled antimicrobial nanomaterials exhibit optimal and biomimetic organization leading to activity at low doses of their toxic components. Antimicrobial bilayer fragments, bilayer-covered or multilayered nanoparticles, functionalized inorganic or organic polymeric materials, coatings and hydrogels disclose their potential for environmental and public health applications in this review.

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Conjugates and nano-delivery of antimicrobial peptides for enhancing therapeutic activity

Cited by 38 publications

References 190 publications

Production of Bioactive Peptides from Lactic Acid Bacteria: A Sustainable Approach for Healthier Foods

Production of Bioactive Peptides from Lactic Acid Bacteria: A Sustainable Approach for Healthier Foods

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

Self-Assembled Antimicrobial Nanomaterials

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