Conjugated polymer nanostructures displaying highly photoactivated antimicrobial and antibiofilm functionalities

Ghosh, Srabanti; Amariei, Georgiana; Mosquera, Marta E. G.; Rosal, Roberto

doi:10.1039/d1tb00469g

Cited by 11 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to their use in various electrochemical sensing platforms, functionalized PEDOT nanostructures are promising candidates for applications in biology, electronics, and materials science. − There have been a few reports on the use of electropolymerization to deposit conducting polymers in the active channel areas of OECTs. − Nevertheless, tailoring functionalized PEDOT nanostructures in the active channel area of OECT devices and investigating the effects of such nanostructures on sensing, particularly of sweat biomarkers, has remained unexplored. We are unaware of any previous investigations into nanostructure engineering through template-free electropolymerization or of the use of nanostructures of functionalized PEDOT derivatives in OECT channel areas to target the detection of cortisol in sweat, with wearable applications in mind.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Detection of Sweat Cortisol Using an Organic Electrochemical Transistor Featuring Nanostructured Poly(3,4-Ethylenedioxythiophene) Derivatives in the Channel Layer

et al. 2022

View full text Add to dashboard Cite

In this study, we examined the influence of functionalized poly(3,4-ethylenedioxythiophene) (PEDOT) nanostructures decorated on the channel layer of an organic electrochemical transistor (OECT) for the detection of sweat cortisol, an adrenocorticosteroid stress hormone. The OECT device featured a bilayer channel confined by a PEDOT:polystyrenesulfonate (PSS) underlayer and a nanostructure-decorated upper layer engineered from the monomers EDOT-COOH and EDOT-EG3 through template-free electrochemical polymerization. This molecular design allowed antibody conjugation using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysulfosuccinimide coupling through the carboxylic acid side chain, with EDOT-EG3 known to minimize nonspecific binding of biomolecules. We also engineered an OECT device having a channel area without any nanostructures to gain insight into the effect of the nanostructures on cortisol sensing. Our new nanostructure-embedded OECT device facilitated real-time detection of cortisol at concentrations ranging from 1 fg/mL to 1 μg/mL with a detection limit of 0.0088 fg/mL with good linearity (R 2 = 0.9566), in addition to excellent selectivity toward cortisol among other structurally similar interfering compounds and high stability and reproducibility. With its rapid response for the detection of 100 ng/mL cortisol-spiked artificial sweat, this nanostructure-decorated OECT device has potential clinical practicality and utility in wearable sensors for future healthcare applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Sensitive Detection of Sweat Cortisol Using an Organic Electrochemical Transistor Featuring Nanostructured Poly(3,4-Ethylenedioxythiophene) Derivatives in the Channel Layer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Recently, Ghosh and co-workers reported photocatalytic bacterial inactivation by employing two distinct conjugated polymer nanostructures (CPNs): polythiophene (PEDOT) and polyaniline (PANI). 123 As supported by the in vitro bactericidal assay, both the CPNs were shown to exhibit antimicrobial activity against S. aureus and E. coli under ultraviolet A (UVA) irradiation. However, negligible inhibition of bacterial growth was observed with bulk PEDOT and PANI without light.…”

Section: Synthetic Macromolecule-based Antibiofilm Agentsmentioning

confidence: 98%

Inhibition and eradication of bacterial biofilm using polymeric materials

Banerjee

Chowdhury

Bauri³

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…164 Ghosh et al (2021) showed that two types of conductive polymer nanofibers (CPNs) including polythiophene (PEDOT) and polyaniline (PANI) showed strong antimicrobial activity against E. coli and S. aureus biofilms. 165 The bactericidal activity of these CPNs is attributed to the generation of ROS (reactive oxygen species) induced by photostimulation, which can cause damage to the bacterial cell membranes and subsequently restrict biofilm formation.…”

Section: Metal and Metal Oxidementioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

View full text Add to dashboard Cite

Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

show abstract

Conjugated polymer nanostructures displaying highly photoactivated antimicrobial and antibiofilm functionalities

Abstract: This work report the use of conjugated polymer nanostructures (CPNs) as photoactivated antimicrobial compounds against gram-positive and gram-negative microorganisms. Two representative CPNs of polythiophene (PEDOT) and polyaniline (PANI) were prepared...

Cited by 11 publications

References 43 publications

Sensitive Detection of Sweat Cortisol Using an Organic Electrochemical Transistor Featuring Nanostructured Poly(3,4-Ethylenedioxythiophene) Derivatives in the Channel Layer

Sensitive Detection of Sweat Cortisol Using an Organic Electrochemical Transistor Featuring Nanostructured Poly(3,4-Ethylenedioxythiophene) Derivatives in the Channel Layer

Inhibition and eradication of bacterial biofilm using polymeric materials

Advances in Nanotechnology for Biofilm Inhibition

Contact Info

Product

Resources

About