Inhibition and eradication of bacterial biofilm using polymeric materials

Banerjee, Arnab; Chowdhury, Pampa; Bauri, Kamal; Saha, Biswajit; De, Priyadarsi

doi:10.1039/d2bm01276f

Cited by 21 publications

(21 citation statements)

References 163 publications

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“…Many of the most difficult-to-treat nosocomial and chronic infections are biofilmassociated. 42,43 Therefore, we next addressed whether polysulfoniums alone and in combination with Rif had synergistic bactericidal activity against biofilms. The antibiofilm activity of PolyS + -100 and PolyS + -34 polymers was investigated after 24 h of exposure with the 3-day-mature biofilms of E. coli and S. aureus at different concentrations on the basis of MIC values (Figure 6).…”

Section: Synthesis and Characterization Of Polys + Polymersmentioning

confidence: 99%

Enhanced Synergistic Antibacterial and Antibiofilm Efficacy of Main-Chain Polysulfoniums with Antibiotics by Balancing Charge Density and Amphiphilicity

Zhao

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Infection diseases caused by Gram-negative pathogens are exceedingly difficult to treat because their characteristic outer membrane limits antibiotic entry. Herein, we report the development of main-chain polysulfoniums with different charge densities and amphiphilicities based on the quantitative methylation reaction. By regulating the membrane-disruption capability, the combined efficacy of polysulfoniums and antibiotic rifampicin can be manipulated from no interaction to synergy against Gram-negative bacteria Escherichia coli. After incubating with synergistic polysulfoniums/rifampicin combinations at a minimum inhibitory concentration (MIC), the time needed to achieve a 6-log reduction of E. coli can be accelerated 8 times compared to the antibiotic treatment. At 1/2 MIC, polysulfoniums/rifampicin combinations can provide a 90% reduction in biofilm mass and 8-log orders of embedded bacteria killing in 3-day-mature E. coli biofilms. This work demonstrates that alkylation chemistry can serve as a reliable means to create antibiotic adjuvants in combating infections caused by Gram-negative pathogens and biofilms.

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Section: Synthesis and Characterization Of Polys + Polymersmentioning

confidence: 99%

Enhanced Synergistic Antibacterial and Antibiofilm Efficacy of Main-Chain Polysulfoniums with Antibiotics by Balancing Charge Density and Amphiphilicity

Zhao

Wang

et al. 2023

ACS Appl. Polym. Mater.

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“…This penetration can occur with disruption of the EPS, providing a means of completely disrupting biofilms. Then, cationic nanomaterials can kill the resident bacteria through membrane disruption [ 53 ]. These capabilities make nanomaterials a “one-stop shop” for the treatment of biofilm infections [ 54 ].…”

Section: Nanomaterials As Therapeutics Against Biofilmsmentioning

confidence: 99%

Nanomaterials for Fighting Multidrug-Resistant Biofilm Infections

Rotello

2023

BME Front

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Multidrug-resistant bacterial infections represent a dire threat to global health. The development of antibiotic resistance in bacteria coupled with the lack of development of new antibiotics is creating infections requiring antibiotics of last resort, and even some infections for which we have no available treatment. Biofilm-based infections present some of the most challenging targets for treatment. The biofilm matrix provides a physical barrier that can impede access of antibiotics and antimicrobials to resident bacteria. The phenotypic diversity found in biofilms further exacerbates the difficulty of eliminating infections, with quiescent “persister” cells evading therapeutics and re-initiating infections after treatment. Nanomaterials provide a tool for combatting these refractory biofilm infections. The distinctive size regime and physical properties of nanomaterials provide them with the capability to penetrate and disrupt biofilms. Nanomaterials can also access antimicrobial pathways inaccessible to conventional antimicrobials, providing a synergistic strategy for treating biofilm infections. This review will summarize key challenges presented by antibiotic resistance and biofilms when treating infection and provide selected examples of how nanomaterials are being used to address these challenges.

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“…Such antibacterial coatings or multicomponent mixtures can thus become a viable or complementary alternative to regular surface cleaning. 52–54…”

Section: Introductionmentioning

confidence: 99%

Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties

Fernandes,

Macedo,

Cabral

et al. 2024

RSC Appl. Interfaces

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Inhibition and eradication of bacterial biofilm using polymeric materials

Abstract: Biofilms, ubiquitous in nature, are three-dimensional complex microbial communities sheathed with a self-secreted extracellular polymeric matrix. Infections caused by these communities have sprouted as serious threats to global healthcare systems...

Cited by 21 publications

References 163 publications

Enhanced Synergistic Antibacterial and Antibiofilm Efficacy of Main-Chain Polysulfoniums with Antibiotics by Balancing Charge Density and Amphiphilicity

Enhanced Synergistic Antibacterial and Antibiofilm Efficacy of Main-Chain Polysulfoniums with Antibiotics by Balancing Charge Density and Amphiphilicity

Nanomaterials for Fighting Multidrug-Resistant Biofilm Infections

Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties

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