Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease

Bassaganya‐Riera, Josep; Hontecillas, Raquel; Horne, William; Sandridge, Mikki; Herfarth, Hans H; Bloomfeld, Richard S.; Isaacs, Kim L.

doi:10.1016/j.clnu.2012.03.002

Cited by 84 publications

(57 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CLA have been intensively studied for their beneficial biological activities in a variety of disease models (6), including mouse and pig models of colitis (3,5), and a clinical trial in patients with Crohn's disease (4). In contrast, information concerning the biological function of CLnA is still scarce (55).…”

Section: Discussionmentioning

confidence: 99%

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

Coursodon-Boyiddle

Snarrenberg

Adkins-Rieck

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

Coursodon-Boyiddle

Snarrenberg

Adkins-Rieck

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, findings of other researchers showed that a diet containing 1% t10,c12 or 9t,t11 in rats reduced the incidence and growth of colon cancer by inducing apoptosis in colonic mucosa of rats treated with 1,2-dimethylhydrazine. 30,31 In a clinical trial, Bassaganya-Riera et al 14 found that CLA supplementation (6 g/d for 12 weeks) in patients with Crohn's disease suppressed the ability of peripheral blood T cells to produce proinflammatory cytokines and decreased disease activity. They concluded that CLA supplementation represents a new complementary treatment for gut inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Conjugated Linoleic Acid Supplementation on Inflammatory Factors and Matrix Metalloproteinase Enzymes in Rectal Cancer Patients Undergoing Chemoradiotherapy

et al. 2013

View full text Add to dashboard Cite

Objectives. The aims of this study were to determine the effect of conjugated linoleic acid (CLA) supplementation on inflammatory factors and matrix metalloproteinase (MMP) enzymes in rectal cancer patients undergoing chemoradiothetrapy. Method and Material. In this randomized, double-blind, placebo-controlled pilot study, 34 volunteer patients with rectal cancer undergoing chemoradiotherapy assigned into the CLA group (n = 16), receiving 3 g CLA/d, and placebo group (n = 18) receiving placebo capsules (sunflower oil) for 6 weeks. The supplementation began 1 week before starting RT (loading period) and continued every day during treatment. Before and after intervention, serum tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, MMP-2, MMP-9, and high-sensitivity C-reactive protein (hsCRP) were measured by enzymelinked immunosorbent assay (ELISA) kits and immunoturbidimetric method, respectively. Independent t tests and paired t tests were used to compare parameters between and within groups, respectively. Results. In the CLA group, the mean serum TNF-α, IL-1β, hsCRP, MMP-9, and MMP-2 levels reduced insignificantly. However, significant changes in TNF-α (P = 0.04), hsCRP (P = 0.03), and MMP-9 (P = 0.04) concentrations were observed in the CLA group when compared with the placebo group. The mean serum IL-6 level remained unchanged in the CLA group but increased remarkably in the placebo group. Conclusion. According to our results, CLA supplementation improved inflammatory factors, MMP-2, and MMP-9 as biomarkers of angiogenesis and tumor invasion. It seems that CLA may provide new complementary treatment by reducing tumor invasion and resistance to cancer treatment in patients with rectal cancer.

show abstract

“…More recently, we have investigated the immunoregulatory efficacy of CLA in CD patients (Bassaganya-Riera et al, 2012a). Thirteen patients with mild to moderately active CD were enrolled in an open-label study of CLA.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Modulation of inflammation and immunity by dietary conjugated linoleic acid

Viladomiu¹,

Hontecillas²,

Bassaganya‐Riera

2016

European Journal of Pharmacology

Self Cite

139

View full text Add to dashboard Cite

Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease

Cited by 84 publications

References 32 publications

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

Effect of Conjugated Linoleic Acid Supplementation on Inflammatory Factors and Matrix Metalloproteinase Enzymes in Rectal Cancer Patients Undergoing Chemoradiotherapy

Modulation of inflammation and immunity by dietary conjugated linoleic acid

Contact Info

Product

Resources

About