Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

Coursodon-Boyiddle, Christine F.; Snarrenberg, Chelsea L.; Adkins-Rieck, Camille K.; Bassaganya‐Riera, Josep; Hontecillas, Raquel; Lawrence, Peter; Brenna, J. Thomas; Jouni, Zeina E.; Dvořák, Bohuslav

doi:10.1152/ajpgi.00248.2012

Cited by 49 publications

(57 citation statements)

References 57 publications

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“…Significantly higher numbers in animals with NEC were returned to normal values by adding glucan into the formula. These findings corresponded to the results obtained in a study evaluating the effects of pomegranate seed oil [20].…”

Section: Resultssupporting

confidence: 88%

“…RNA concentration was quantified by ultraviolet spectrophotometry at 260 nm, and the purity and integrity were determined using a NanoDrop (Thermo Fisher Scientific, Wilmington, DE) [19]. RT real-time PCR assays were performed to quantify steady-state mRNA levels of selected molecules IL-12p35, TNF-β, iNOS, CXCL1, Tff3, and Muc-2 [20]. cDNA was synthesized from 0.2 μg of total RNA.…”

Section: Rna Preparation and Real-time Pcrmentioning

confidence: 99%

See 1 more Smart Citation

Yeast-Derived ? -Glucan Reduces Intestinal Injury in Rat Model of Necrotizing Enterocolitis

Větvička¹,

Arriola²,

Kaveti³

et al. 2015

ICPJL

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Section: Resultssupporting

confidence: 88%

Section: Rna Preparation and Real-time Pcrmentioning

confidence: 99%

Yeast-Derived ? -Glucan Reduces Intestinal Injury in Rat Model of Necrotizing Enterocolitis

Větvička¹,

Arriola²,

Kaveti³

et al. 2015

ICPJL

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“…Newborn rat pups were weighed and placed in an incubator to control body temperature. Animals were fed six times a day with a total volume of 850 μl (12) …”

Section: Animal Model and Experimental Designmentioning

confidence: 99%

Peroxisome proliferator-activated receptor-γ agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model

et al. 2016

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Background: Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity. Methods: We studied preterm rats in which NEC was induced using the hypoxia-hypothermia model. The treatment group (TG; n = 30) received enteral PIO (10 mg/kg/d) for 72 h and the control group (CG; n = 30) did not. Animals were sacrificed 96 h after birth. NEC was diagnosed evaluating histological ileum changes, and mRNA levels of IL-4, IL-12, IL-6, IL-10, INF-γ, and TNF-α cytokines were measured. results: NEC occurrence was higher in the CG (18/30; 60%) than in the TG (5/30; 16.7%) and was more severe. Proinflammatory IL-12 and INF-γ mRNA levels were significantly lower in the TG than in the CG; conversely, the antiinflammatory IL-4 mRNA level was significantly higher in the TG than in the CG. conclusion: Our results demonstrate for the first time that PIO is effective in reducing the incidence and severity of NEC and in decreasing renal injuries in a preterm rat model. n ecrotizing enterocolitis (NEC) is the most common neonatal gastrointestinal complication in preterm infants (1). The prevalence of this disease is about 7% in infants with birth weght from 500 to 1,500 g, with a mortality of 30% in 28 to 36 wk of gestation infants and 40 % in <28-wk infants (2). Moreover, the development of NEC increases the risk of a delay in neurodevelopment, because inflammatory processes occurring in the gut can have a systemic diffusion, affecting other organs such as the brain (3), and, as recently suggested, the kidney (4). The physiopathology of NEC is not completely understood; however it is considered a multifactoral disease including intestinal immaturity, microbial colonization, and hypoxia-ischemia damage as risk factors. Recently, many studies have suggested that the intestinal mucosa and innate immune system play major roles in the pathogenesis of NEC (5). Thus, factors affecting innate immunity and regulating inflammation, such as the nuclear peroxisome proliferatoractivated receptors (PPAR), could be crucial. PPAR are a family of ligand-activated nuclear receptor transcription factors that regulates the function and expression of complex gene networks, especially involved in energy homeostasis and inflammation (6). They consist of three isoforms (α, β, γ), and PPARγ has been shown to induce anti-inflammatory responses inhibiting proinflammatory transcription factors such as nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) (7-9). Moreover, PPARγ can promote an antiinflammatory antioxidant response interacting with different enzymatic pathways such as cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) (6). For these reasons, many PPARγ agonists have been implicated in t...

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“…In addition they postulated that PA has considerable useful effects on integrity of gastrointestinal mucosa. In this study it was believed that PA is very important nutritional factor in the future [35] . Also cold pressed PSO inhibited both cyclooxygenase and lipoxygenase enzymes in vitro [25] .…”

Section: Antioxidant and Antiinflammatory Effects Of Pamentioning

confidence: 90%

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

Bedel¹,

Turgut²,

Kurtoğlu³

et al. 2017

pharmaceutical-sciences

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Bedel, et al.: Pharmacology of Punicic AcidPlant extracts and nutraceuticals are the most ancient and widespread form of medication employed by the general population. The pomegranate is a prehistoric, mystical and a highly differentiated fruit. Moreover, pomegranate is found in some medicinal systems as a cure for a variety of illnesses. Pomegranate has been used for a long time for nutraceutical purposes. Current research indicates that the most medicinally useful pomegranate components include ellagitannins, anthocyanins, anthocyanidins, flavonoids, estrogenic flavonols and flavones. Also pomegranate seed oil contains 64-83% punicic acid. Therefore, this review focussed on the effects of punicic acid, particularly those that have been reported such as the anticarcinogenic, antioxidant, antiinflammatory and antidiabetic effects. As nutraceuticals appear to play a major role in the prophylaxis of various diseases, punicic acid could be an important and phytoconstituent among these agents. Nutraceuticals are generally regarded as safe to use with lower incidence of side effects. In spite of all these reports it is obvious that there is a clear need for more clinical studies.

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Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis

Abstract: Coursodon-Boyiddle CF, Snarrenberg CL, Adkins-Rieck CK, Bassaganya-Riera J, Hontecillas R, Lawrence P, Brenna JT, Jouni ZE, Dvorak B. Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis.

Cited by 49 publications

References 57 publications

Yeast-Derived ? -Glucan Reduces Intestinal Injury in Rat Model of Necrotizing Enterocolitis

Yeast-Derived ? -Glucan Reduces Intestinal Injury in Rat Model of Necrotizing Enterocolitis

Peroxisome proliferator-activated receptor-γ agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

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