Congenital Vitamin E Deficiency

Hadi, Hamza El; Vettor, Roberto; Rossato, Marco

doi:10.1007/978-3-319-40007-5_86-1

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…Vitamin E (or V E ) is a fat-soluble vitamin vital to human health. , It is commonly used to treat threatened/habitual abortion and to serve as an important antioxidant which prevents and treats cardiovascular disease, arteriosclerosis, and aging, etc . Due to its great demand and huge market potential, a few technologies have been developed for V E production in the past, while more efficient and economical technologies are emerging. ,, …”

Section: Introductionmentioning

confidence: 99%

Synthesizing Vitamin E Molecularly Imprinted Polymers via Precipitation Polymerization

Zhu

Zhang

et al. 2019

J. Chem. Eng. Data

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Molecularly imprinted polymers (MIPs) were prepared by the precipitation polymerization process, with vitamin E as the template molecule, ethylene glycol dimethacrylate as the cross-linker, and three different functional monomers, respectively. Adsorption experiments were conducted to investigate the performance of each MIP and compared to the nonimprinted polymers (NIPs). It was found that MIPs are superior to NIPs in general, with acrylamide-based MIP showing the best adsorption capacity of 38.8 mg·g–1 and an imprinting factor of 2.6. The optimal imprinting ratio and cross-linking ratio to be 1:5 and 5:1, respectively. The Freundlich equation was found superior to Langmuir to describe the adsorption isotherm data on the MIP/NIP. The adsorption of vitamin E on the MIP was found to be a heterogeneous process and consists of two mechanisms, which were confirmed by the analysis of the thermodynamic properties of the adsorption process.

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Section: Introductionmentioning

confidence: 99%

Synthesizing Vitamin E Molecularly Imprinted Polymers via Precipitation Polymerization

Zhu

Zhang

et al. 2019

J. Chem. Eng. Data

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“…It is acknowledged that vitamin E is the major lipid-soluble chain-breaking antioxidant found in the human body. In addition to its anti-oxidative properties, molecules of the vitamin E family exertanti-atherogenicand anti-inflammatory activities [ 6 ]. Although the pathogenesis of NAFLD and its progression to fibrosis needs to be fully clarified, it is believed that oxidative stress plays a crucial role in producing the lethal hepatocyte injury associated with NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth?

2018

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Obesity is one of the major epidemics of this millennium, and its incidence is growing worldwide. Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become a disease of increasing prevalence and a leading cause of morbidity and mortality closely related to cardiovascular disease, malignancies, and cirrhosis. It is believed that oxidative stress is a main player in the development and progression of NAFLD. Currently, a pharmacological approach has become necessary in NAFLD because of a failure to modify lifestyle and dietary habits in most patients. Vitamin E is a potent antioxidant that has been shown to reduce oxidative stress in NAFLD. This review summarizes the biological activities of vitamin E, with a primary focus on its therapeutic efficacy in NAFLD.

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“…VE has potent antioxidant activities and has been shown to reduce oxidative stress in NAFLD. [ 32 ] It could increase the actions of antioxidative enzymes such as SOD, catalase, and GSH‐Px and decrease the form of nitric oxide synthase and adenine dinucleotide phosphate oxidase which are major contributors to oxidative stress. [ 31 ] There has been an increasing interest in the function of VE supplementation aiming to use VE as the therapeutic approach for NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with Docosahexaenoic Acid and Vitamin E Improves Hepatic Triglyceride Accumulation Induced by High‐Fat Diet in Mice

Yuan

Tan

et al. 2020

Euro J Lipid Sci & Tech

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The study aims to investigate the effect of combined supplementation with docosahexaenoic acid (C22:6 n‐3, DHA) and vitamin E (VE) on the oxidative stress and liver triglycerides (TG) accumulation induced by high‐fat diet (HFD) in mice. C57BL/6J mice are fed either a control diet or an HFD for 8 weeks. Animals are supplemented with DHA, VE, or DHA + VE, respectively. Supplementation with DHA alone shows significant improvement in oxidative stress and hepatic steatosis in mice. Supplementation with DHA significantly reduces the liver TG and total cholesterol contents, and the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, compared with the HFD. Supplementation with DHA also significantly decreases the mRNA expression level of sterol regulatory element‐binding protein 1C. However, supplementation with VE alone does not show improvement in oxidative stress and hepatic steatosis. DHA + VE supply obtains a superior effect in alleviation of hepatic steatosis than DHA supplementation alone in mice fed by HFD. The efficacy of DHA potentiated by VE can be due to that VE enhances the effect of DHA in decrease of ALT and AST levels and increase of antioxidant enzyme activity and glutathione level in mice fed by HFD. Practical Applications: Supplementation with DHA significantly improves the oxidative stress and hepatic steatosis induced by HFD in mice. The efficacy of DHA in the alleviation of hepatic steatosis induced by HFD is potentiated by VE. These findings may provide a rational basis for the use of DHA and VE co‐supplementation in patients with liver steatosis.

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Congenital Vitamin E Deficiency

Cited by 7 publications

References 70 publications

Synthesizing Vitamin E Molecularly Imprinted Polymers via Precipitation Polymerization

Synthesizing Vitamin E Molecularly Imprinted Polymers via Precipitation Polymerization

Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth?

Supplementation with Docosahexaenoic Acid and Vitamin E Improves Hepatic Triglyceride Accumulation Induced by High‐Fat Diet in Mice

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