Synthesizing Vitamin E Molecularly Imprinted Polymers via Precipitation Polymerization

Abstract

Molecularly imprinted polymers (MIPs) were prepared by the precipitation polymerization process, with vitamin E as the template molecule, ethylene glycol dimethacrylate as the cross-linker, and three different functional monomers, respectively. Adsorption experiments were conducted to investigate the performance of each MIP and compared to the nonimprinted polymers (NIPs). It was found that MIPs are superior to NIPs in general, with acrylamide-based MIP showing the best adsorption capacity of 38.8 mg·g–1 and an imprinting factor of 2.6. The optimal imprinting ratio and cross-linking ratio to be 1:5 and 5:1, respectively. The Freundlich equation was found superior to Langmuir to describe the adsorption isotherm data on the MIP/NIP. The adsorption of vitamin E on the MIP was found to be a heterogeneous process and consists of two mechanisms, which were confirmed by the analysis of the thermodynamic properties of the adsorption process.

Solid-Phase Extraction of Active Compounds from Natural Products by Molecularly Imprinted Polymers: Synthesis and Extraction Parameters

“…The SEM analysis shows that spherical particles were obtained with a diameter of around 0.2 µm for the MIPs, while an interconnected-irregular bulk was observed in the NIPs. This morphological characterization shows the successful synthesis of MIPs and further proves by Lu et al [60] revealed that MIP particles were spherical and well dispersed. The morphology of MIP AM synthesized at various crosslinkers is illustrated in Figure 8.…”

“…Lu et al [60] observed peaks (Figure 12) at 1150 cm −1 may be related to the vibration of the C-O bond stretching in EGDMA (a). Peaks at 3400 cm −1 correspond to -NH groups, 1637 cm −1 to the stretching vibration of the C=C double bond, and 1720 cm −1 to the stretching vibration of C=O groups, respectively, in AM (b).…”

Molecularly Imprinted Polymers in Biological Applications

“…Iridoid glycosides, spiramycin, 2,4-dichlorophenoxyacetic acid, diclofenac, alfatoxins [17][18][19][20][21] Suspension polymerization Malachite green, p-hydroxybenzoic acid, timolol, alfatoxins B1, Pb 2+ [22][23][24][25][26] Emulsion polymerization Quercetin, malachite green, Listeria monocytogenes, triazines, Cd 2+ [27][28][29][30][31] Seed polymerization Nicotinamide, bisphenol A, promazine derivates [32][33][34] Precipitation polymerization Triclosan and triclocarban, strychnine, caffeic acid, vitamin E, prednisolone [35][36][37][38][39] RAFT polymerization Benzimidazole, propranolol, polycyclic aromatic hydrocarbons [40][41][42] Atom transfer radical polymerization Ofloxacin, ␤2-agonists [43,44] Sol-gel Iprodione, methylxanthines [45,46] RAFT: Reversible addition fragmentation chain transfer.…”

Designing and controlling the morphology of spherical molecularly imprinted polymers

“…The average particle size of MIPs was about 400 nm while the average particle size of spherical NIPs was 800 nm, which indicated that the template could affect the particle size. Subsequently, precipitation polymerization was employed to prepare many spherical MIPs for selective recognition of tetracycline, 26 vitamin E, 27 etc. The key point of this method was the solubility and amount of solvent.…”