Congenital melanocytic nevi of the small and garment typeClinical histologic, and ultrastructural studies

Mark, G; Mihm, Martín C.; Liteplo, Merrill; Reed, Richard J.; Clark, Wallace H.

doi:10.1016/s0046-8177(73)80101-7

Cited by 259 publications

(125 citation statements)

References 36 publications

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“…It also illustrates that nerve involvement is not necessarily a sign of malignancy especially in hamartomatous lesions. Similar involvement has been reported in cases of congenital melanocytic nevi [2], H yman et al [4] have pointed out the variability of angiomatous component and abnormalities of the sweat ducts in these lesions. The vascular component in the present case was mainly formed by thin-walled capillaries.…”

Section: Commentsupporting

confidence: 76%

Eccrine Angiomatous Hamartoma: a Rare Skin Lesion with Diverse Histological Features

Challa

Jona²

1977

Dermatology

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A case of painful eccrine angiomatous hamartoma of the wrist in a 10-year-old girl is presented. It was located in the reticular dermis and contained abnormal tubules resembling eccrine secretory coils and thin vascular channels dispersed in the collagenous tissue of the dermis. Some eccrine ducts showed dilatation. The noteworthy features of this case were the absence of hyperhidrosis over the lesion, and the presence of focal neural infiltration by the tubular structures. Electron microscopy showed mostly clear cells and occasional dark cells lining the tubular structures. This case supports the theory of abnormal induction of heterotypic dependency with resultant malformation of adnexal as well as mesenchymal elements.

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Section: Commentsupporting

confidence: 76%

Eccrine Angiomatous Hamartoma: a Rare Skin Lesion with Diverse Histological Features

Challa

Jona²

1977

Dermatology

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“…Moss noted that this cleavage plane is not present in the normal skin and that it is not located at the junctional area of the nevus [13]. In 1973, Mark et al mentioned that in the reticular dermis and subcutis, nevus cells in CMN are usually disposed as single cells between collagen bundles and fat cells, but also found nevus cells in the hair follicles which are surrounded by collagen sheaths with anchors in the subcutis, and in the erector pili muscles [9].…”

Section: Resultsmentioning

confidence: 99%

Results of early curettage of giant congenital melanocytic nevi; a report of eight cases and review of the literature

2007

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The aim of this study was to investigate the longterm cosmetic and oncologic results following early curettage of giant congenital melanocytic nevi (GCMN). Neonates with GCMN treated with curettage within 4 weeks of age and with a minimum follow-up of 2 years were evaluated at the outpatient department. Scar formation was evaluated by means of the patient and observer scar assessment scale (POSAS). Biopsy specimens were analysed. In 9 years, eight neonates were treated. The mean follow-up period was 5.6 years. Six (75%) patients developed re-pigmentation of the curetted skin, hypertrichosis returned in five cases. One patient developed hypertrophic scars, all others formed good scars. None of the patients developed a melanoma. Biopsy specimens showed nevus cells in the skin after curettage. In 50% of the patients curettage is followed by severe re-pigmentation. Since this treatment does not remove all nevus cells, long-term followup is essential to detect malignant transformation.

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“…Factors often associated with the possibility of malignant degeneration include location of the lesion, presence of neurocutaneous melanocytosis, and depth and distribution of the pigmentation. However, the risk of malignancy is also increased by the presence of larger nevi (greater than 50 cm), axial location such as trunk, head and neck, the presence of multiple satellite lesions, and the existence of nodules, dark patches, junctional activity, deep dermal neurogenic element or a blue nevus component (2,(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Congenital giant nevocellular nevus of the back with deep extension to the fat and fascia

Jaeger¹

2006

CAN J PLAST SURG

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MRO Jaeger, RM Zuker. Congenital giant nevocellular nevus of the back with deep extension to the fat and fascia. Can J Plast Surg 2006;14(1):45-48.The presence of deep pigmentation in a giant congenital nevus makes its complete removal very difficult and should be taken into consideration when planning for treatment. A clinical case in which the pigmented lesion was found to extend deep into the muscle fascia is described. The lesion was surgically removed with an acceptable functional and aesthetic result through the utilization of tissue expansion. The development of new surgical techniques and the expansion of laser technology will possibly provide new treatment options in the future. Emphasis should be placed on aesthetics and function, because the excision based only on oncological anticipation is no longer valid. The presence of deep pigmentation makes certain treatment options less effective than surgical ablation.Key Words: Giant congenital nevi; Laser; Tissue expanders Naevus cellulaire congénital géant dans le dos, avec pénétration profonde dans le tissu adipeux et le fascia La présence d'une pigmentation profonde dans un naevus congénital géant rend son excision complète très difficile, et cet aspect devrait être pris en considération lorsque vient le moment de planifier le traitement. Voici un cas clinique de lésion pigmentée avec pénétration profonde dans le fascia. La lésion a été excisée convenablement des points de vue fonctionnel et esthétique par le recours à des expanseurs tissulaires. La mise au point de nouvelles techniques chirurgicales et le développement de la technologie laser déboucheront peut-être sur l'élaboration d'autres traitements. Une attention particulière devrait être portée aux aspects esthé-tique et fonctionnel, parce qu'aujourd'hui l'excision fondée sur le seul critère de la prévision oncologique ne suffit plus. La présence d'une pigmentation profonde rend certains traitements moins efficaces que l'excision chirurgicale.

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Congenital melanocytic nevi of the small and garment typeClinical histologic, and ultrastructural studies

Cited by 259 publications

References 36 publications

Eccrine Angiomatous Hamartoma: a Rare Skin Lesion with Diverse Histological Features

Eccrine Angiomatous Hamartoma: a Rare Skin Lesion with Diverse Histological Features

Results of early curettage of giant congenital melanocytic nevi; a report of eight cases and review of the literature

Congenital giant nevocellular nevus of the back with deep extension to the fat and fascia

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