Congenital Diaphragmatic Hernia and Neonatal Lung Lesions

Kays, David W.

doi:10.1016/j.suc.2005.12.016

Cited by 24 publications

(6 citation statements)

References 149 publications

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“…Congenital diaphragmatic hernia (CDH) is usually an isolated non-syndromic presentation, but it has been associated with a number of genetic lesions, the most common of which are chromosomal duplications 7. In one study, 15% of children with Morgagni hernia, as in this case, had DS 8.…”

Section: Discussionmentioning

confidence: 66%

Down syndrome masked by Marfan syndrome in a neonate

2013

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A male neonate with maternally inherited Marfan syndrome was also diagnosed with Down syndrome at 3 weeks of age. To our knowledge this is the first described case in the literature of the co-occurrence of Down syndrome and Marfan syndrome in a neonate. The diagnosis of Down syndrome was delayed and we hypothesise that Marfan syndrome had masked the usual phenotypic features of Down syndrome. The phenotype of this child is intriguing and has lead to speculation of the possible interaction of the two syndromes.

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Section: Discussionmentioning

confidence: 66%

Down syndrome masked by Marfan syndrome in a neonate

2013

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“…Still, survival rates reported in the literature have ranged from 50–90% overall, with many “benchmark” centers reporting survival rates of 78–95%. 3,5,6 …”

Section: Introductionmentioning

confidence: 99%

Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care

Tracy

Mears

Smith

et al. 2010

Journal of Pediatric Surgery

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Purpose Variable approaches to the care of infants with congenital diaphragmatic hernia (CDH) by multiple providers may contribute to inconsistent care. Our institution developed a comprehensive evidence-based protocol to standardize the management of CDH infants. This report reviews patient outcomes prior to and after implementation of the protocol. Methods Retrospective chart review of CDH infants managed with individualized care (Pre-protocol group, January 1997–December 2001, n=22) or on the protocol (Protocol group, January 2002–July 2009, n=47). Survival and other categorical variables were compared by chi square analysis and continuous variables were compared using one-sided ANOVA analysis with significance defined as p<0.05. Results Survival to discharge was significantly greater in the Protocol group (40/47 (85%)) than the Pre-protocol group (12/22 (52%) p=.006) although mean gestational age, mean birth weight, and expected survival were not statistically different between the two groups. The use of supportive therapies, including high frequency jet ventilation, inhaled nitric oxide, and extracorporeal life support was similar between groups as well. Conclusions Since implementation of a management protocol for infants with CDH, survival has improved significantly compared with expected survival and pre-protocol controls. Reduction in the variability of care through use of an evidence-based protocol use may improve the survival of CDH infants.

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“…Antenatally, bronchopulmonary sequestration can be complicated by nonimmune fetal hydrops, or hydrothorax. [ 8 14 ] Postnatally, it may be complicated by infection and rarely torsion, infarction or hemothorax. [ 3 ] The prognosis of extralobar sequestration in the absence of severe anomalies is good.…”

Section: Discussionmentioning

confidence: 99%

Extralobar sequestration of lung associated with congenital diaphragmatic hernia and malrotation of gut

et al. 2015

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Extralobar sequestration of lung is a rare congenital malformation frequently diagnosed during repair of congenital diaphragmatic hernia. However, the combined association of congenital diaphragmatic hernia with both pulmonary sequestration and malrotation of gut is rare. We report a case of a 1-year-old girl with extralobar sequestration of lung and malrotation of gut detected during the repair of diaphragmatic hernia. The histopathological examination of the sequestered lobe revealed dilated bronchioles, alveolar ducts and alveoli along with dilated subpleural and peribronchiolar lymphatics and areas of type II congenital pulmonary airway malformation.

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Congenital Diaphragmatic Hernia and Neonatal Lung Lesions

Cited by 24 publications

References 149 publications

Down syndrome masked by Marfan syndrome in a neonate

Down syndrome masked by Marfan syndrome in a neonate

Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care

Extralobar sequestration of lung associated with congenital diaphragmatic hernia and malrotation of gut

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