Congenital cytomegalovirus infection: a cause of sensorineural hearing loss.

Peckham, Catherine; Stark, O; Dudgeon, J. A.; Martin, John D.; Hawkins, GC

doi:10.1136/adc.62.12.1233

Cited by 69 publications

(49 citation statements)

References 23 publications

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“…Once again, comparative prevalence rates were not available from the Trent or national prevalence studies and therefore generalisation is less robust. However, the UK Child Development Studies reported 0.8 in 1000 children aged 7 years to have such an impairment, 37 and other historical surveys have reported profound unilateral hearing impairment in 1 in 1000 schoolchildren (many studies cited by Bess and colleagues 1986 25 ). These were of the same order as the prevalence rate reported in the cohort 3, NNHS.…”

Section: Prevalencementioning

confidence: 99%

See 1 more Smart Citation

Current practice, accuracy, effectiveness and cost-effectiveness of the school entry hearing screen

Bamford¹,

Fortnum²,

Bristow³

et al. 2007

Health Technol Assess

120

153

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Section: Prevalencementioning

confidence: 99%

“…All studies received an 'unclear' for this question as none of them clearly states what data were available to them at the time of testing. [30][31][32][33][34][35][36][37]. The two-by-two tables for sensitivity and specificity, where available, are presented in Appendix 10.…”

Section: Quality Of Included Studiesmentioning

confidence: 99%

Current practice, accuracy, effectiveness and cost-effectiveness of the school entry hearing screen

Bamford¹,

Fortnum²,

Bristow³

et al. 2007

Health Technol Assess

120

153

View full text Add to dashboard Cite

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“…Most countries choose to perform the neonatal hearing screening before discharge out of the maternity unit. However, different studies have shown that testing soon after birth results in a greater percentage of false-positive results (24,30), which undermine the credibility of the test and lead to unnecessary pressure for parents and personnel. Also from a therapeutic point of view, there is no reason for testing infants directly after birth, since there are no immediate solutions for hearing improvement and revalidation is offered only from the second or third month after birth.…”

Section: Discussionmentioning

confidence: 99%

Detection of Perinatal Cytomegalovirus Infection and Sensorineural Hearing Loss in Belgian Infants by Measurement of Automated Auditory Brainstem Response

Verbeeck

Kerschaver²,

Beuselinck³

et al. 2008

J Clin Microbiol

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Since auditory disability causes serious problems in the development of speech and in the total development of a child, it is crucial to diagnose possible hearing impairment as soon as possible after birth. This study evaluates the neonatal hearing screening program in Flanders, Belgium. The auditory ability of 118,438 babies was tested using the automated auditory brainstem response. We selected 194 babies with indicative hearing impairment and 332 matched controls to investigate the association between the presence of human cytomegalovirus (HCMV) in urine samples and sensorineural hearing loss and to analyze the sensibility and specificity of a cell culture assay and a quantitative PCR detection method. Our results indicate that significantly more babies with confirmed hearing impairment were HCMV positive after birth. Further, based on the results of our study, babies with HCMV viral loads above 4.5 log copies/ml urine seem to be 1.4 times more likely to have confirmed hearing impairment. Our follow-up study suggests that the hearing impairment of children infected with HCMV after birth is less likely to improve than that of HCMV-negative infants. Our results confirm that the presence of HCMV before or shortly after birth influences the outcome of hearing impairment.

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“…Symptoms and signs are ranging from asymptomatic infection to symptomatic severe neonatal disease [1]. Despite advances in epidemiology and knowledge of CMV, its wide clinical manifestations have made congenital cytomegalovirus infection a diagnostic challenge [2]. We described a case of congenital cytomegalovirus infection which presented with feeding intolerance, seizures, recurrent hypoglycaemia and persistent thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Feeding Intolerance, Seizures, Recurrent Hypoglycemic Episodes and Persistent Thrombocytopenia: A Case of Symptomatic Congenital Cytomegalovirs Infection

Mdcjp¹,

S²,

Kumara³

2017

Ped Health Res

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The human cytomegalovirus (CMV) is universally distributed among human populations as one of the most common cause of congenital infection and it is a diagnostic dilemma for clinicians owning its wide range of clinical presentations. Fetal infection results from transmission of the virus across the placenta and is particularly common in women who experience primary infection during pregnancy. Here we report a newborn with congenital CMV infection with diagnostic challenge.

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Congenital cytomegalovirus infection: a cause of sensorineural hearing loss.

Cited by 69 publications

References 23 publications

Current practice, accuracy, effectiveness and cost-effectiveness of the school entry hearing screen

Current practice, accuracy, effectiveness and cost-effectiveness of the school entry hearing screen

Detection of Perinatal Cytomegalovirus Infection and Sensorineural Hearing Loss in Belgian Infants by Measurement of Automated Auditory Brainstem Response

Feeding Intolerance, Seizures, Recurrent Hypoglycemic Episodes and Persistent Thrombocytopenia: A Case of Symptomatic Congenital Cytomegalovirs Infection

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