Conflict behavior and dynamics of monoamines of various brain nuclei in rats

Sakurai-Yamashita, Yasuko; Ataoka, Y.K.; Yamashita, Kimihiro; Miyazaki, Akira; Ushio, Masuko; Mine, Kazunori; Níwa, Masami; Ueki, Showa

doi:10.1016/0028-3908(89)90119-6

Cited by 13 publications

(3 citation statements)

References 23 publications

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“…Thus, the present findings provide no evidence suggesting the direct involvement of the amygdala serotonergic system (Cheetham, Yamaguchi, & Horton, 1989;Kilpatrick, Jones, & Tyers, 1988, 1989Nieuwenhuys, 1985;Sakurai-Yamashita et al, 1989) in the effects of fluoxetine on memory. Relatively few experiments have investigated the brain system (or systems) mediating the effects of serotonergic influences on memory.…”

Section: Discussioncontrasting

confidence: 93%

Fluoxetine effects on retention of inhibitory avoidance: Enhancement by systemic but not intra-amygdala injections

Introini-Collison

McGaugh

1992

Psychobiology

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Male Sprague-Dawley rats were trained in an inhibitory avoidance task and injected with saline or tluoxetine (15.0 mglk.g i.p.) immediately after training. Fluoxetine significantly facilitated retention assessed on a retention test 48 h later. In contrast, posttraining intra-amygdala injections oftluoxetine (1.0, 3.0, or 10.0 "g) did not modify retention of the inhibitory avoidance task. The findings suggest that the amygdala serotonergic system is not involved in the modulation of memory in this task.It is now well established that memory storage in rats and mice can be enhanced or impaired by posttraining treatments affecting several neurotransmitter or neuromodulatory systems (McGaugh, 1973(McGaugh, , 1983(McGaugh, , 1989. For example, when administered shortly after training, systemic injection of either peripheral or centrally acting adrenergic agonists produces dose-dependent effects on subsequent retention (lntroini-Collison &.

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Section: Discussioncontrasting

confidence: 93%

Fluoxetine effects on retention of inhibitory avoidance: Enhancement by systemic but not intra-amygdala injections

Introini-Collison

McGaugh

1992

Psychobiology

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“…Moreover, the DRN is the major 5-HT innervation of the amygdala (Parent, Descarries, & Beaudet, 1981). Putative anxiety-producing procedures such as conflict lead to the accumulation of the 5-HT metabolite 5-hydroxyindole acetic acid in the basolateral amygdala (Sakurai-Yamoshita et al, 1989). In addition, both 5-HT 2 (Hodges et al, 1987) and 5-HT 3 (Costall, Kelly, Naylor, Onaivi, & Tyers, 1989) antagonists reduce fearlike or anxious behavior when microinjected into the amygdala.…”

Section: Discussionmentioning

confidence: 99%

The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.

Maier¹,

Grahn²,

Kalman³

et al. 1993

Behavioral Neuroscience

159

131

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It has been argued that exposure to inescapable shock produces later behavioral changes such as poor shuttle box escape learning because it leads to the conditioning of intense fear, which later transfers to the shuttle box test situation and interferes with escape. Both fear, as assessed by freezing, and escape were measured in Sprague-Dawley rats 24 hr after exposure to inescapable shock. Lesions of the basolateral region and central nucleus of the amygdala eliminated the fear that transfers to the shuttle box after inescapable shock, as well as the fear conditioned in the shuttle box by the shuttle box shocks. However, the amygdala lesions did not reduce the escape learning deficit produced by inescapable shock. In contrast, dorsal raphe nucleus lesions did not reduce the fear that transfers to the shuttle box after inescapable shock, but eliminated the enhanced fear conditioning in the shuttle box as well as the escape deficit. The implications of these results for the role of fear and anxiety in mediating inescapable shock effects are discussed.

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“…We found that direct ap plication of diazepam into the dorsal HIP (d HIP) elicited a potent anticonflict action, determined using a Vogel type conflict test (6). Based on our observations (7,8), BDZ seem to disinhibit behavioral suppression by modulating activities in these brain areas.…”

mentioning

confidence: 59%

A key role of the mammillary body in mediation of the antianxiety action of zopiclone, a cyclopyrrolone derivative.

et al. 1989

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Abstract-The present study was designed to elucidate the brain site of the anti conflict action of zopiclone (ZOP), a cyclopyrrolone derivative, using the rat conflict procedure.ZOP at 10 /cg/,al, bilaterally injected into the mammillary body (MB), produced a significant increase in the punished responses, with no change in the unpunished responses.There were no significant changes in these responses when ZOP was injected into the central amygdala, frontal cortex or dorsal hippocampus. Attention should be given to the possibility that the MB is the site of the anti conflict action of ZOP.

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Conflict behavior and dynamics of monoamines of various brain nuclei in rats

Cited by 13 publications

References 23 publications

Fluoxetine effects on retention of inhibitory avoidance: Enhancement by systemic but not intra-amygdala injections

Fluoxetine effects on retention of inhibitory avoidance: Enhancement by systemic but not intra-amygdala injections

The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.

A key role of the mammillary body in mediation of the antianxiety action of zopiclone, a cyclopyrrolone derivative.

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