Cone Adaptation in Age-Related Maculopathy

Brown, Brian; Tobin, Christopher; Roche, Neil; Wolanowski, Andrew

doi:10.1097/00006324-198606000-00009

Cited by 44 publications

(20 citation statements)

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“…Not only is the amplitude of the photopic a-wave reduced but the implicit time is also prolonged, indicating that remaining cones, or at least their synaptic transmission, is slower than in elderly normals. These findings support the data of Brown and coworkers, who described elevated cone adaptation thresholds and also concluded a more peripheral involvement in the disease [5].…”

Section: Discussionsupporting

confidence: 92%

“…Indeed, either in the EOG and in the ERG we found significant differences between ARMD patients and age-matched normal controls. With psychophysical tests in ARMD changes of the retinal sensitivity and affected cone adaptation have been described, which supports these findings [5,6,31]. Vascular changes seen in ARMD may be one of the mechanisms responsible for a more global retinal dysfunction [10,13,23,25].…”

Section: Discussionmentioning

confidence: 55%

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Electrophysiological abnormalities in age-related macular degeneration

Walter

Widder

Lüke

et al. 1999

Graefe's Archive for Clinical and Experimental Ophthalmology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 55%

Electrophysiological abnormalities in age-related macular degeneration

Walter

Widder

Lüke

et al. 1999

Graefe's Archive for Clinical and Experimental Ophthalmology

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“…[1][2][3][4][5][6][7][8][9][10][11] There have been several studies showing impairment of the photopic and scotopic pathways in early ARM subjects. 8,10,[12][13][14][15][16] Phipps et al 12 demonstrated an alteration of cone adaptational kinetics by measuring the post-bleaching recovery time to various contrast multiples.…”

Section: Introductionmentioning

confidence: 99%

Monitoring retinal function in early age-related maculopathy: visual performance after 1 year

Feigl

Brown

Lovie‐Kitchin

et al. 2004

Eye

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Purpose To monitor visual performance in early age-related maculopathy (ARM). Methods We measured monocular visual functionFhigh-contrast visual acuity (HC-VA), central visual fields (mean sensitivity, MS), colour vision (desaturated Panel D-15), Pelli-Robson (P-R), and coneand rod-mediated multifocal electroretinograms (mfERG) in 13 ARM subjects and 13 age-matched control subjects with normal fundi at baseline and after 1 year. All had visual acuity of 6/12 or better. The mfERG data were compared to templates derived from the control group at baseline. We analysed the mfERG results by averaging the central and peripheral fields and the superior and inferior fields (CP and SI methods) and by calculating the local responses. Results The mean rod-mediated responses were significantly delayed in the ARM group for the CP (P ¼ 0.04) and the SI methods (P ¼ 0.03) at baseline compared to the control group. This did not change significantly after 1 year, whereas the mean cone-mediated responses were within the normal range at both times. Although the local analysis revealed lower amplitudes for the cone-and rod-mediated responses at baseline this was not found after 1 year and only the local rodmediated latencies were delayed at both times (Po0.01). HC-VA, desaturated Panel D-15 and P-R were significantly worse in the ARM group (Pp0.01) at baseline but did not show further significant deterioration. Progressive fundus changes were found in only two subjects (18%).

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“…Colour discrimination Bowman 1980, 45 Bowman and Cameron 1984, 46 Collins 1986, 47 Applegate et al 1987, 48 Collins and Brown 1989a, 49 Sunness et al 1989, 50 Haegerstrom-Portnoy and Brown 1989, 51 Eisner et al 1992, 52 Cheng and Vingrys 1993, 40 Feigl et al 2004 53 Colour matching Smith et al 1988, 54 Eisner et al 1987a and b, 1991, 1992 34,52,55,56 Contrast sensitivity: Sjostrand 1979, 57 Brown and Lovie-Kitchin 1987, 36 Kleiner et al spatial/temporal/colour 1988, 58 Collins and Brown 1989a, 49 Owsley et al 1990, 59 Frennerson et al 1995, 60 Midena et al 1997, 61 Phipps 38 Swann and Lovie-Kitchin 1991, 39 Cheng and Vingys 1993, 40 Tolentino et al 1994, 41 Midena et al 1994, 1997, 61,65 Sheu et al 2002, 66 Phipps et al 2004, 67 Goldstein et al 2005 68 Cone adaptation Brown et al 1986, 69 Collins and Brown 1989a and b, 49,70 dynamics/glare recovery Brown and Lovie-Kitchin 1989a, 71 Eisner et al 1987a and b, 1991, 1992 34,52,55,56 Cheng and Vingys 1993, 40 Sandberg and Gaudio 1995, 72 Sandberg et al 1998, 73 Midena et al 1997, …”

Section: Visual Function Publicationsmentioning

confidence: 99%

Assessment of age‐related maculopathy using subjective vision tests

Lovie‐Kitchin

Feigl

2005

Clinical and Experimental Optometry

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This paper reviews non-standard, clinical vision tests that may be used to detect the earliest visual loss in age-related maculopathy (ARM), before fundus changes are detected. We recommend a clinical test battery for all patients aged 60 years and older, comprising low luminance/low contrast (SKILL) VA or low contrast VA, desaturated D-15 colour vision assessment, flicker perimetry, glare recovery and dark adaptation if possible, together with conventional assessments of case history, ophthalmoscopy and high contrast visual acuity (VA) for the detection and diagnosis of ARM. Reading rate is also discussed as a potential indicator of early visual loss. For monitoring the progressive visual loss in age-related macular degeneration (AMD) and determining the requirements for optometric vision rehabilitation, we recommend more conventional clinical vision tests of distance and near visual acuity, reading rate, the effects of varying illumination and a functional central visual field assessment.

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Cone Adaptation in Age-Related Maculopathy

Cited by 44 publications

References 0 publications

Electrophysiological abnormalities in age-related macular degeneration

Electrophysiological abnormalities in age-related macular degeneration

Monitoring retinal function in early age-related maculopathy: visual performance after 1 year

Assessment of age‐related maculopathy using subjective vision tests

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