Electrophysiological abnormalities in age-related macular degeneration

Walter, Peter; Widder, Randolf A.; Lüke, Christoph; Königsfeld, Pia; Brunner, Richard

doi:10.1007/s004170050331

Cited by 55 publications

(58 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in accordance with evidence that AMD related abnormalities extend beyond the parafovea, especially as the disease progresses. 20,30,[36][37][38][39][40] For example, Owsley et al 40 demonstrated a significant deficit NC indicates that rod intercept could not be calculated due to threshold dropping too rapidly to below 3.0 log units of stimulus attenuation (due to insufficient bleach intensity or bleach ineffectively delivered), UD indicates unreliable data (fixation errors exceeding 30%). * RIT was not reached within the maximum test duration, and a value of 30 minutes was ascribed.…”

Section: Discussionmentioning

confidence: 99%

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Binns

Taylor

Edwards

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Binns AM, Taylor DJ, Edwards LA, Crabb DP. Determining optimal test parameters for assessing dark adaptation in people with intermediate age-related macular degeneration. Invest Ophthalmol Vis Sci. 2018;59:AMD114-AMD121. https:// doi.org/10.1167/iovs.18-24211 PURPOSE. The primary aim was to determine optimal test conditions for evaluating dark adaptation in intermediate age-related macular degeneration (iAMD) in order to minimize test time while maintaining diagnostic sensitivity.METHODS. People with AMD and age-similar controls were recruited (aged >55 years). Rod intercept time (RIT) was assessed after a 76%, 70%, and 65% rhodopsin bleach at 58 eccentricity and 76% and 70% bleach at 128. Test order was randomized and a 30-minute washout period added between tests. Results were compared between control and iAMD groups and receiver operating characteristics (ROC) curves were constructed. RESULTS.A total of 26 participants with variable grades of macular health attended for two visits. There was a statistically significant difference in average RIT between the control and iAMD groups at 58 (median, IQR controls ¼ 5.8 minutes, 3.8-7.5; iAMD ¼ 20.6 minutes, 11.1-30.0; Mann-Whitney, P ¼ 0.01) and at 128 (mean, controls: 4.54 minutes 6 2.12 SD, iAMD ¼ 7.72 minutes 6 3.37 SD; independent samples t-test, P ¼ 0.03) following a 76% bleach. Area under the ROC curves was 0.83 (confidence interval [CI]: 0.64-1.0) and 0.79 (CI: 0.59-0.99) for these two test conditions, respectively. Five participants (45%) in the iAMD group had RITs >20 minutes for 76% bleach at 58, but none for any other test condition.CONCLUSIONS. Nearly half of the participants with iAMD produced unacceptably long recovery times (>20 minutes) using a 76% bleach at 58 eccentricity. The 76% bleach at 128 provided almost equivalent separation between AMD and controls but recovery was achieved within 20 minutes.

show abstract

Section: Discussionmentioning

confidence: 99%

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Binns

Taylor

Edwards

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…1 Based on electrophysiological testing, it remains controversial whether rods are primarily affected or both rods and cones are similarly affected. [24][25][26][27][28][29][30][31][32][33] Microperimetry has detected photoreceptor abnormalities even before GA develops, and this strategy can also predict the area where existing GA will likely progress. [34][35][36][37][38][39][40] These histopathologic, electrophysiologic, and microperimetric findings in eyes with GA, along with the early visual function deficits and symptoms observed in patients even before GA develops, 41 suggest that photoreceptor dysfunction precedes the appearance and progression of GA in some eyes.…”

Section: Introductionmentioning

confidence: 99%

Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

Nunes¹,

Gregori²,

Yehoshua³

et al. 2013

Ophthalmic Surg Lasers Imaging Retina

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVE: Spectral-domain optical coherence tomography (SD-OCT) en face imaging was used to measure the growth of geographic atrophy (GA) and identify baseline anatomic changes in the outer retina in eyes with nonexudative age-related macular degeneration (AMD). PATIENTS AND METHODS: In this prospective study, eyes were imaged using 200 × 200 and 512 × 128 A-scan raster patterns. Outer retinal anatomy was visualized using en face imaging of a 20-μm thick slab encompassing the inner segment/outer segment (IS/OS) band. RESULTS: En face SD-OCT imaging of the IS/OS region revealed a bilaterally symmetrical pattern of outer retinal disruption extending beyond the borders of GA that accurately predicted the progression of GA over 1 year in 13 of 30 eyes (43.3%). In the remaining cases, the area of disruption was much larger than the area of progression. CONCLUSION: En face imaging of the outer retina can predict the growth of GA in some eyes. Due to the bilateral symmetry of these findings, this imaging strategy may identify a genetic subset of patients in whom photoreceptor loss precedes the progression of GA. These areas with outer retinal disruption should be followed in clinical trials designed to test treatments for dry AMD. [ Ophthalmic Surg Lasers Imaging Retina. 2013;44:344–359.]

show abstract

“…Currently available approaches to objectively evaluate macular function include conventional electrophysiological tests and newer multifocal techniques. [1][2][3][4] Owing to the relatively low sensitivity and specificity of conventional electrophysiological tests in macular diseases, multifocal techniques, especially multifocal electroretinograms, have gained increasing popularity in the evaluation of macular diseases. Although a large number of studies have evaluated the use of multifocal electroretinograms in evaluating macular dysfunction, few studies have assessed the use of multifocal visual evoked potentials (mfVEP) in macular diseases.…”

Section: Introductionmentioning

confidence: 99%

Application of multifocal visual evoked potentials in the assessment of visual dysfunction in macular diseases

Jiang

Zhang

Xie

et al. 2011

Eye

View full text Add to dashboard Cite

Electrophysiological abnormalities in age-related macular degeneration

Abstract: In addition to data from psychophysical tests the results from electrophysiological examinations indicated a global reduction of retinal function in ARMD which seemed to be present not only in the macula but also elsewhere in the retina.

Cited by 55 publications

References 24 publications

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

Application of multifocal visual evoked potentials in the assessment of visual dysfunction in macular diseases

Contact Info

Product

Resources

About