Conductive nerve guide conduits based on wet-adhesive hydrogel to accelerate peripheral nerve repair

Cai, Chao; Zhu, Huimin; Chen, Yujie; Chen, Chi; Li, Hua; Yang, Zhi; Liu, Hezhou

doi:10.1016/j.apmt.2022.101491

Cited by 16 publications

(14 citation statements)

References 45 publications

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“…Meanwhile, the gelatin and GelMA were further characterized by 1 H NMR. As shown in Figure S1(B), the presence of two proton peaks at 5.29 and 5.63 ppm was attributed to the unsaturated H on the carbon double bond …”

Section: Resultsmentioning

confidence: 97%

“…As shown in Figure S1(B), the presence of two proton peaks at 5.29 and 5.63 ppm was attributed to the unsaturated H on the carbon double bond. 26 In addition, drugs (lidocaine) and Ag NPs are added to the inner matrix to endow the hydrogel with analgesic and antibacterial effects. Ag NPs have been approved by the US Food and Drug Administration (FDA) for use as antimicrobial dressings.…”

Section: Resultsmentioning

confidence: 99%

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Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

et al. 2022

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Dynamic full-thickness skin wound healing remains an intricate problem due to the humid environment and frequent exercise. Recently, multifunctional hydrogels have a great promise in wound repair. However, traditional hydrogels only keep the wound moist, protect the wound from bacterial infection, and cannot actively drive dynamic wound closure. Inspired by embryo wound active closure, we constructed a double-sided thermoresponsive mechanoactive (DTM) hydrogel that combines good flexibility, self-healing, wet-tissue adhesion, and antibacterial functions. The strong adhesion of the hydrogel to biological tissues is attributed to "multiple hydrogen bonding clusters" without any chemical reaction. The contraction force triggered by temperature is quickly transmitted to dynamic wound edges to resist external mechanical forces and drive wound closure, which can effectively avoid damage to surrounding healthy tissue and reduce the risk of scarring, infection, and inflammation caused by sutures, staples, or clips. Strikingly, in vivo, this hydrogel bandage actively enhanced wound repair in a full-thickness skin defect model by promoting collagen deposition, facilitating angiogenesis, and accelerating wound re-epithelialization. This mechanoactive biological method will provide a facile strategy for joint wound management and demonstrates strong potential in tissue remodeling.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

et al. 2022

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“…The presence of catechol in TA is believed to fulfill the dual role of interfacial binding and the solidification of the adhesive proteins [ 40 ]. Catechol is capable of diverse chemistries, which enable it to bind to both organic and inorganic surfaces through the formation of reversible non-covalent or irreversible covalent interactions [ 29 , 30 ]. Based on the catechol groups of oxidized polyphenols mimicking the mussel adhesion mechanism, the TA@BC hydrogels exhibited unique adhesiveness to a wide range of surfaces [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…TA-coated BC improved its uniform distribution in the hydrogel, and natural polyphenol TA formed hydrogen bonds with polymer that also toughen the polymer network [ 28 ]. Moreover, a large number of catechol groups supplied by TA can bind to both inorganic and organic surfaces through the formation of reversible noncovalent or irreversible covalent interactions [ 21 , 29 , 30 ]. The ionic conductive hydrogels can adapt to different deformations (including stretching and compression) and present a stable response to various stimuli through relative resistance changes (RRCs) and the hydrogel can maintain high ionic conductivities of 0.36 S/m at −35 °C.…”

Section: Introductionmentioning

confidence: 99%

High Multi-Environmental Mechanical Stability and Adhesive Transparent Ionic Conductive Hydrogels Used as Smart Wearable Devices

Liu

Chen

et al. 2022

Polymers

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Ionic conductive hydrogels used as flexible wearable sensor devices have attracted considerable attention because of their easy preparation, biocompatibility, and macro/micro mechanosensitive properties. However, developing an integrated conductive hydrogel that combines high mechanical stability, strong adhesion, and excellent mechanosensitive properties to meet practical requirements remains a great challenge owing to the incompatibility of properties. Herein, we prepare a multifunctional ionic conductive hydrogel by introducing high-modulus bacterial cellulose (BC) to form the skeleton of double networks, which exhibit great mechanical properties in both tensile (83.4 kPa, 1235.9% strain) and compressive (207.2 kPa, 79.9% strain) stress–strain tests. Besides, the fabricated hydrogels containing high-concentration Ca2+ show excellent anti-freezing (high ionic conductivities of 1.92 and 0.36 S/m at room temperature and −35 ∘C, respectively) properties. Furthermore, the sensing mechanism based on the conductive units and applied voltage are investigated to the benefit of the practical applications of prepared hydrogels. Therefore, the designed and fabricated hydrogels provide a novel strategy and can serve as candidates in the fields of sensors, ionic skins, and soft robots.

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“…Functional hydrogels are widely concerned by researchers because of their promising applications in flexible electronic devices, − wound dressings, − tissue repairing, and other fields. − Benefiting from their soft and wet nature, hydrogel adhesives display advantages such as biocompatibility, − controllable adhesiveness, − and moist environment for wound healing. − However, the applications of these materials on biointerfaces are limited by their brittleness. Another shortcoming of hydrogel adhesives is their deteriorated adhesion strength in a wet biological environment since their ionic attraction with the substrate would be screened by the electrolytes in the biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Synergy of Host–Guest and Cation−π Interactions for an Ultrastretchable, pH-Tunable, Surface-Adaptive, and Salt-Resistant Hydrogel Adhesive

Yang

Jin

et al. 2022

Chem. Mater.

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The adhesion to wet, acidic, and saline biointerfaces with large deformation is important in the fields of wound dressing and motion monitoring but has proven to be extremely challenging. There is a need for a facile method to improve the stretchability and salt resistance simultaneously. Here, an ultrastretchable, pH-tunable, surface-adaptive, and salt-resistant hydrogel adhesive is reported. The hydrogel adhesive is prepared through cross-linking acrylamide with a supramolecular complex of poly(β-cyclodextrin) (PCD) and benzimidazole (BI). The dynamic association between PCD and BI causes an extra energy dissipation and improves the breaking strain to be larger than 4000%. The hydrogel exhibits stable adhesiveness to varieties of surfaces due to the multiple types of hydrogel–surface interactions, including ionic bond, π–π stacking, and hydrogen bond. Notably, the adhesive strength of the hydrogel gets significantly enhanced in an acidic environment and shows no attenuation in a saline environment. This is due to the unique adjacent cation−π structure of BI: the imidazole can be protonized upon acidification, and the phenyl group can repel water and enhance the ionic attraction with the substrates. The ultrastretchability, the stable adhesion on biointerfaces, and the salt resistance render the hydrogel a promising candidate for the surgical patch and motion sensors that serve in wet, acidic, and dynamic environments.

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Conductive nerve guide conduits based on wet-adhesive hydrogel to accelerate peripheral nerve repair

Cited by 16 publications

References 45 publications

Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

High Multi-Environmental Mechanical Stability and Adhesive Transparent Ionic Conductive Hydrogels Used as Smart Wearable Devices

Synergy of Host–Guest and Cation−π Interactions for an Ultrastretchable, pH-Tunable, Surface-Adaptive, and Salt-Resistant Hydrogel Adhesive

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