Condrossarcoma em paciente com osteocondromatose múltipla: relato de caso e revisão da literatura

Gomes, Anna Caroline Nobre; Silveira, Cláudio Régis Sampaio; Paiva, Roberto; Junior, Antônio Gilson Monte Aragão; Castro, J R

doi:10.1590/s0100-39842006000600015

Cited by 13 publications

(11 citation statements)

References 8 publications

(22 reference statements)

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“…In these, it may be possible to differentiate between lesions with well-defined and indistinct margins, or to note that the lesion increases in size, or to note that its mineralization takes on the appearance of opaque glass. 7 Radiography of the right foot of our patient showed a tumor with imprecise limits that compromised the calcaneus, talus and lateral malleolus. The lesion had a destructive, aggressive and osteolytic appearance, with invasion of surrounding soft tissues and the presence of points of calcification in the tumor formation.…”

Section: Discussionmentioning

confidence: 63%

“…Furthermore, they are commonly associated with the hereditary syndrome of multiple exostosis in 6% of the cases. 7 , 8 Since osteochondromas are commonly asymptomatic, the patients are unaware of the existence of the lesion, such that sudden pain and rapidly growing pain are the clinical manifestations of suspected malignancy, along with focal compressive neuropathy. 9 The process of malignant transformation occurs at a frequency of 5%.…”

Section: Discussionmentioning

confidence: 99%

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Calcaneal chondrosarcoma: a case report

Moraes

Linhares

Domingues

et al. 2014

Revista Brasileira de Ortopedia (English Edition)

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The objective was to report on a rare case of chondrosarcoma of the bones of the foot, and specifically the calcaneus. The patient was a 30-year-old woman with a complaint of painless nodulation on the lateral face of the calcaneus, which she had had for around eight years, which then started to present significant pain. Radiography showed a tumor with imprecise limits, compromising the calcaneus, talus and lateral malleolus. The lesion had a destructive, aggressive and osteolytic appearance, with invasion of the surrounding soft tissues and the presence of points of calcification. Amputation was performed in the middle third of the right lower leg, with a histological diagnosis of chondrosarcoma. The case evolved with local recurrence of the tumor formation and subsequent amputation in the middle third of the right thigh. One year after the second amputation, the patient evolved with metastasis from the chondrosarcoma in soft tissues throughout the body and in the lungs, and she died one year and ten months after the diagnosis was made. Chondrosarcomas that involve the calcaneus are rare in young adults, with few reports in the literature. For this reason, the present report becomes important in that it shows that even though this is a rare condition, it is present in our environment. Early investigation is essential, especially by means of imaging examinations, with the aim of diminishing the chances of malignant transformation and consequent complications, so as to avoid death.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Calcaneal chondrosarcoma: a case report

Moraes

Linhares

Domingues

et al. 2014

Revista Brasileira de Ortopedia (English Edition)

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“…Magnetic resonance imaging (MRI) is the "gold standard" in the characterization of tumors of the musculoskeletal system, on account of its high resolution, tissue contrast, and multiplanar capacity (1)(2)(3)(4)(5)(6) . Additionally, MRI offers several advantages when compared with other imaging methods in the evaluation and staging of bone and soft tissue tumors (3) .…”

Section: Introductionmentioning

confidence: 99%

Espectroscopia de prótons e perfusão por ressonância magnética na avaliação dos tumores do sistema musculoesquelético

et al. 2009

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OBJETIVO: Avaliar a espectroscopia de prótons e o estudo dinâmico do contraste por ressonância magnética na diferenciação dos tumores musculoesqueléticos benignos e malignos. MATERIAIS E MÉTODOS: Foram estudados 55 pacientes com tumores musculoesqueléticos (27 malignos e 28 benignos). Os exames foram realizados em aparelho de ressonância magnética de 1.5 T com protocolo convencional e espectroscopia de prótons com TE de 135 ms. O estudo dinâmico do contraste foi adquirido pela sequência T1 gradiente-eco após a administração intravenosa de gadolínio. Curvas de intensidade de sinal versus tempo e valores de slope foram calculados. A análise estatística foi realizada pelo teste de Levene, seguido pelo teste t de Student, além dos testes qui-quadrado de Pearson e exato de Fischer. RESULTADOS: A sensibilidade, especificidade e acurácia da espectroscopia de prótons foram, respectivamente, de 87,5%, 92,3% e 90,9% (p < 0,0001). Além disso, houve significativa diferença entre o valor quantitativo da curva entre as lesões benignas (média de 27,5% por minuto) e malignas (média de 110,9% por minuto) (p < 0,0001). CONCLUSÃO: Os estudos quantitativo e qualitativo da análise dinâmica do contraste por ressonância magnética associados à presença do pico de colina são úteis na diferenciação dos tumores musculoesqueléticos em benignos e malignos.

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“…Radiologicamente a lesão apresenta osteólise e reação periosteal e pode conter pontos de calcificação e ossificação intralesional e espessamento da cortical (KEALY & McALLISTER, 2005). A radiografia, embora inespecífica, poderá apresentar informações valiosas ao cirurgião, pois, quanto mais radiotransparente o tumor, mais alta a probabilidade de que seja de alto grau de malignidade (GOMES et al, 2006). Um tumor de crescimento lento e de baixo grau causa espessamento reativo do córtex, gerando um aumento de volume endurecido como o apresentado no animal relatado.…”

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“…Um tumor de crescimento lento e de baixo grau causa espessamento reativo do córtex, gerando um aumento de volume endurecido como o apresentado no animal relatado. Por sua vez, uma neoplasia de alto grau, mais agressiva, destrói o córtex e forma uma massa de tecidos moles (GOMES et al, 2006).…”

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