Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007

Leroy, Eric M.; Nkoghe, D.; Ollomo, Benjamin; Nze-Nkogue, Chimene; Becquart, Pierre; Grard, Gilda; Pourrut, Xavier; Charrel, Rémi N.; Moureau, Grégory; Ndjoyi-Mbiguino, Angélique; Lamballerie, Xavier de

doi:10.3201/eid1504.080664

Cited by 212 publications

(211 citation statements)

References 14 publications

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“…21 We documented the simultaneous presence of CHIKV, dengue virus, and leptospirosis infection in the community as well as the concurrent presence of CHIKV and dengue antibodies in same subjects. 22,23 However, the contribution of leptospiral and dengue viral infection in the present outbreak is low, which is evidenced by low seropositivity to these infections among the patients affected during the outbreak.…”

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confidence: 90%

Outbreak of Chikungunya Fever, Dakshina Kannada District, South India, 2008

Manimunda¹,

Sugunan²,

Subhodh³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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The outbreak of chikungunya fever that surfaced in India during late 2005 has affected more than 1.56 million people, spread to more than 17 states/union territories, and is still ongoing. Many of these areas are dengue- and leptospirosis-endemic settings. We carried out a cross-sectional survey in one such chikungunya-affected location in Dakshina Kannada District of Karnataka State to estimate the magnitude of the epidemic and the proportion of chikungunya virus (CHIKV) infections that remained clinically inapparent. The seropositivity for CHIKV infection was 62.2%, and the attack rate of confirmed CHIK fever was 58.3%. The proportion of inapparent CHIKV infection was 6.3%. The increasing trend in the seropositivity and attack rate of CHIKV infection with age group was statistically significant. The present study is an indicator of the magnitude of the ongoing outbreak of CHIKV infection in India that started during 2005–2006.

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confidence: 90%

Outbreak of Chikungunya Fever, Dakshina Kannada District, South India, 2008

Manimunda¹,

Sugunan²,

Subhodh³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…[9][10][11] In India, concurrent isolation of CHIKV and DENV had been reported since 1964 from different States. 2,9 In 2010, a hospital-based study revealed co-circulation of CHIKV and DENV in some areas of West Bengal, India with high morbidity.…”

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confidence: 99%

A Comparative Study of Clinical Features between Monotypic and Dual Infection Cases with Chikungunya Virus and Dengue Virus in West Bengal, India

Taraphdar¹,

Sarkar²,

Mukhopadhyay³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Chikungunya virus (CHIKV) and dengue virus (DENV) are circulating individually in the state of West Bengal, India. However, after 1965 the dual-infection caused by both viruses had not been recorded until 2010. In 2010, an investigation of the febrile cases was carried out to confirm the involvement of both viruses simultaneously. A total of 550 blood samples were tested for the detection of immunoglobulin M (IgM) antibody against both CHIKV and DENV. Serology by the enzyme-linked immunosorbent assay method confirmed that 131 (23.8%) and 104 (18.9%) patients had IgM antibody against CHIKV and DENV, respectively, whereas 68 (12.4%) had IgM antibodies against both CHIKV and DENV. Fever, joint pain, rashes, headache, myalgia, and nausea/vomiting are the common features in the case of both monotypic and dual-infection. Severe arthralgia and swelling of joints were common only in CHIKV-positive cases and abdominal pain was mainly associated with DENV infection. Diarrhea was reported only by the dual-infected patients (16.2%).

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“…Though previous records of concurrent infections of dengue and chikungunya (Myers and Carey, 1967;Leroy et al, 2009;Chang et al, 2010;Harendra et al, 2009) and concurrent infections of dengue and malaria (Charrel, 2005;Hati et al, 2012) exist, this is the first ever report of concurrent infections of dengue, chikungunya and malaria (P. falciparum).…”

Section: Introductionmentioning

confidence: 99%

“…In serial blood specimens collected from this patient the authors demonstrated an increase in antibody against both the viruses mentioned. Concurrent dengue virus and chikungunya virus infections during simultaneous outbreaks in Gabon in Africa in 2007 were documented, where either dengue-2 virus or chikungunya infections were identified in 321 patients at molecular level applying PCR technique, of which 8 had co-infections (Leroy et al, 2009). Concurrent isolation of dengue virus and chikungunya virus from a confirmed case imported from Singapore was described in Taiwan; the virus was detected through antibody neutralization and plaque purification techniques (Chang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Concurrent Infections of Three Mosquito Borne Diseases-Dengue, Chikungunya and Malaria

Hati¹,

Chandra²,

Mukherjee³

et al. 2016

jmr

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Kolkata, India is endemic for mosquito borne diseases like dengue, chikungunya and malaria. For monitoring, altogether 252 serum samples of fever cases were examined for dengue specific NS1 antigen and IgM and IgG antibodies and chikungunya specific IgM antibody. Their blood samples were also tested for malarial parasites. Out of 252 cases, 15 (5.95%), 16 (6.34%) and 18 (7.13%) were infected with dengue, chikungunya and malaria respectively. Amongst 15 dengue cases 10 (3.96%) were positive for both dengue IgM and IgG antibodies and 5 (1.98%) for NS1 antigen. Out of 18 malaria victims 14 (5.55%) and 4 (1.58%) were positive for Plasmodium vivax and Plasmodium falciparum respectively. During the present study, one case of concurrent infections of dengue and chikungunya and another case of concurrent infections of dengue, chikungunya and falciparum malaria were detected. Detail case report of the later has been described. This is the first ever report of concurrent infections of dengue, chikungunya and malaria.

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Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007

Cited by 212 publications

References 14 publications

Outbreak of Chikungunya Fever, Dakshina Kannada District, South India, 2008

Outbreak of Chikungunya Fever, Dakshina Kannada District, South India, 2008

A Comparative Study of Clinical Features between Monotypic and Dual Infection Cases with Chikungunya Virus and Dengue Virus in West Bengal, India

Concurrent Infections of Three Mosquito Borne Diseases-Dengue, Chikungunya and Malaria

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