Outbreak of Chikungunya Fever, Dakshina Kannada District, South India, 2008

Manimunda, Sathya Prakash; Sugunan, A P; Subhodh, K.; Vijayachari, P.; Shriram, A N; Sharma, Sameer; Muthialu, Nagarajan; Chaitanya, Itta Krishna; Rai, Guruprasad; Sudeep, A. B.

doi:10.4269/ajtmh.2010.09-0433

Cited by 32 publications

(21 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All viral detection tests were associated with an immunoassay. We noted that the majority of the studies using IgM ELISA [ 8 , 33 , 35 , 36 , 38 , 44 , 54 , 56 , 60 , 68 , 71 , 76 , 82 , 87 , 108 , 119 , 120 , 120 , 121 , 125 , 128 , 130 – 133 , 139 – 141 , 143 ], NS1 tests [ 149 ] and/or RT-PCR [ 35 , 60 , 76 , 108 , 118 , 141 , 159 , 160 ] were conducted in an outbreak or post-outbreak context (p<0.001), which is not surprising because these tests are used for detecting acute and/or recent infections. Moreover, nearly all cohort studies that described the incidence and/or seroconversion of arboviral infection also used IgM ELISA and/or RT-PCR methods [ 98 , 103 – 105 , 107 – 109 , 111 , 160 ].…”

Section: Resultsmentioning

confidence: 99%

“…With respect to arboviruses, a wide variation in disease spectrum, including asymptomatic infection, is often observed. In the review, 43 studies reported the proportion of asymptomatic forms; these rates ranged between 22% and 99% for DENV (mean: 67%) [ 23 , 35 , 42 – 44 , 48 , 51 , 54 , 56 , 59 , 72 , 73 , 76 , 108 , 152 , 163 ], between 4% and 65% for CHIKV (mean: 26%) [ 119 , 120 , 122 , 123 , 125 , 126 , 128 , 129 , 131 , 133 , 141 , 149 , 152 , 163 ] and between 29% and 80% for ZIKV (mean: 55%) [ 8 , 155 , 159 , 160 ]. However, the rates did not differ significantly among continents for either arbovirus, irrespective of whether the highest rates were in the Americas.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Fritzell¹,

Rousset²,

Adde³

et al. 2018

PLoS Negl Trop Dis

157

137

View full text Add to dashboard Cite

BackgroundArboviral infections are a public health concern and an escalating problem worldwide. Estimating the burden of these diseases represents a major challenge that is complicated by the large number of unapparent infections, especially those of dengue fever. Serological surveys are thus required to identify the distribution of these diseases and measure their impact. Therefore, we undertook a scoping review of the literature to describe and summarize epidemiological practices, findings and insights related to seroprevalence studies of dengue, chikungunya and Zika virus, which have rapidly expanded across the globe in recent years.Methodology/Principal findingsRelevant studies were retrieved through a literature search of MEDLINE, WHOLIS, Lilacs, SciELO and Scopus (2000 to 2018). In total, 1389 publications were identified. Studies addressing the seroprevalence of dengue, chikungunya and/or Zika written in English or French and meeting the inclusion and exclusion criteria were included. In total, 147 studies were included, from which 185 data points were retrieved, as some studies used several different samples. Most of the studies were exclusively conducted on dengue (66.5%), but 16% were exclusively conducted on chikungunya, and 7 were exclusively conducted on Zika; the remainder were conducted on multiple arboviruses. A wide range of designs were applied, but most studies were conducted in the general population (39%) and in households (41%). Although several assays were used, enzyme-linked immunosorbent assays (ELISAs) were the predominant test used (77%). The temporal distribution of chikungunya studies followed the virus during its rapid expansion since 2004. The results revealed heterogeneity of arboviruses seroprevalence between continents and within a given country for dengue, chikungunya and Zika viruses, ranging from 0 to 100%, 76% and 73% respectively.Conclusions/SignificanceSerological surveys provide the most direct measurement for defining the immunity landscape for infectious diseases, but the methodology remains difficult to implement. Overall, dengue, chikungunya and Zika serosurveys followed the expansion of these arboviruses, but there remain gaps in their geographic distribution. This review addresses the challenges for researchers regarding study design biases. Moreover, the development of reliable, rapid and affordable diagnosis tools represents a significant issue concerning the ability of seroprevalence surveys to differentiate infections when multiple viruses co-circulate.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Fritzell¹,

Rousset²,

Adde³

et al. 2018

PLoS Negl Trop Dis

157

137

View full text Add to dashboard Cite

show abstract

“…The primary goal of such passive surveillance is to monitor epidemiologic trends in diseases. In the case of chikungunya, such monitoring was expected to be delayed due to overwhelming case counts, as had been reported during prior outbreaks in immunologically naive populations [8, 10]. In Puerto Rico, the infrastructure for a passive chikungunya surveillance system (PCSS) was already in place, since the Puerto Rico Department of Health (PRDH) and the CDC had collaboratively operated the passive dengue surveillance system (PDSS) since the 1960s [11].…”

Section: Passive Case Surveillancementioning

confidence: 99%

“…Second, laboratory capacity to routinely test suspected cases did not exist. Third, although severe and potentially fatal manifestations of CHIKV infection [4–7] had been reported to occur most frequently in infants and the elderly [8–10], the expected incidence of such manifestations was unclear owing to differences in surveillance methods and potential population-specific differences (eg, underlying comorbidities, demographic age structure, and genetic predisposition). Fourth, multiple acute febrile illnesses (AFIs) are endemic in Puerto Rico, including dengue [11], influenza [12], leptospirosis [13], and melioidosis [14], all of which may be misdiagnosed as chikungunya and vice versa.…”

mentioning

confidence: 99%

Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico

Sharp¹,

Ryff

Alvarado

et al. 2016

J Infect Dis.

View full text Add to dashboard Cite

After chikungunya virus (CHIKV) transmission was detected in Puerto Rico in May 2014, multiple surveillance systems were used to describe epidemiologic trends and CHIKV-associated disease. Of 28 327 cases reported via passive surveillance, 6472 were tested for evidence of CHIKV infection, and results for 4399 (68%) were positive. Of 250 participants in household cluster investigations, 70 (28%) had evidence of recent CHIKV infection. Enhanced surveillance for chikungunya at 2 hospitals identified 1566 patients who tested positive for CHIKV, of whom 10.9% were hospitalized. Enhanced surveillance for fatal cases enabled identification of 31 cases in which CHIKV was detected in blood or tissue specimens. All surveillance systems detected a peak incidence of chikungunya in September 2014 and continued circulation in 2015. Concomitant surveillance for dengue demonstrated low incidence, which had decreased before CHIKV was introduced. Multifaceted chikungunya surveillance in Puerto Rico resolved gaps in traditional passive surveillance and enabled a holistic description of the spectrum of disease associated with CHIKV infection.

show abstract

“…Indeed intensity of transmission in a population, loosely approximated by the attack rate, could be inversely associated to the proportion of unapparent infection. 21 …”

mentioning

confidence: 99%

Seroprevalence of Asian Lineage Chikungunya Virus Infection on Saint Martin Island, 7 Months After the 2013 Emergence

Gay¹,

Rousset²,

Huc³

et al. 2016

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

At the end of 2013, chikungunya virus (CHIKV) emerged in Saint Martin Island, Caribbean. The Asian lineage was identified. Seven months after this introduction, the seroprevalence was 16.9% in the population of Saint Martin and 39.0% of infections remained asymptomatic. This moderate attack rate and the apparent limited size of the outbreak in Saint Martin could be explained by control measures involved to lower the exposure of the inhabitants. Other drivers such as climatic factors and population genetic factors should be explored. The substantial rate of asymptomatic infections recorded points to a potential source of infection that can both spread in new geographic areas and maintain an inconspicuous endemic circulation in the Americas.

show abstract

Outbreak of Chikungunya Fever, Dakshina Kannada District, South India, 2008

Cited by 32 publications

References 12 publications

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review

Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico

Seroprevalence of Asian Lineage Chikungunya Virus Infection on Saint Martin Island, 7 Months After the 2013 Emergence

Contact Info

Product

Resources

About