A Comparative Study of Clinical Features between Monotypic and Dual Infection Cases with Chikungunya Virus and Dengue Virus in West Bengal, India

Taraphdar, Debjani; Sarkar, Arindam; Mukhopadhyay, Biswanath; Chatterjee, Souvik

doi:10.4269/ajtmh.2012.11-0704

Cited by 75 publications

(81 citation statements)

References 15 publications

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“…Se ha descrito la co-circulación del CHIKV y el DENV en la India, Malasia y Sri Lanka 9,11 . La co-infección entre estos dos virus se reportó en 1967 en India 16 .…”

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“…En un estudio en el oeste de Bengala (India), se encontró que los pacientes con co-infección se presentaba más en pacientes adultos, tenían menos artritis, y con más diarrea. En todos se evidenció una fiebre bifásica; sin embargo, no reportaron casos fatales 9 .…”

Section: Discussionunclassified

“…En una u otra infección pueden presentarse dolores articulares y dificultad para la movilización, de intensidad variable. La infección por CHIK-V se ha asociado a mayor compromiso articular [9][10] . Sin embargo, no se ha reportado casos de aumento de la permeabilidad capilar, síndromes de choque o hemorragias graves.…”

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“…Sin embargo, no se ha reportado casos de aumento de la permeabilidad capilar, síndromes de choque o hemorragias graves. En forma infrecuente se han descrito casos fatales con cuadros de encefalopatía, miocarditis y compromiso hepático 9,11 . El DEN-V, por el contrario, se asocia con cuadros clínicos graves, tales como el síndrome de fuga capilar y choque, manifestaciones hemorrágicas, compromiso visceral cardíaco y hepático, con mayor mortalidad 12,13 .…”

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Co-infección por virus del dengue (DEN-V) y virus Chikungunya (CHIK-V) durante un brote epidémico en Cali, Colombia: Comunicación de un caso fatal

Rosso

Pacheco

Rodríguez

et al. 2016

Rev. chil. infectol.

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Co-infección por virus del dengue (DEN-V) y virus Chikungunya (CHIK-V) durante un brote epidémico en Cali, Colombia. Comunicación de un caso fatal Fernando Rosso, Robinson Pacheco, Sarita Rodríguez y Diego Bautista Co-infection by Chikungunya virus (CHIK-V) and dengue virus (DEN-V)during a recent outbreak in Cali, Colombia. Report of a fatal caseThe recent outbreaks of Chikungunya (CHIK-V) virus in endemic areas of dengue (DEN-V) could increase the risk of co-infection. CHIK infection has been considered not severe and with very unusual mortality, however DEN is associated with severe manifestations and increased mortality. Little is known about coinfection. It is possible that co -infection could generate severe cases. We present a case report of co-infection DEN-V -3 and CHIK-V in an elderly patient who developed acute renal failure, dengue shock syndrome (DSS), progresses to multiple organ failure and died. With the recent emergence of CHIK-V in Colombia, the possibility of co-infection with DEN-V should be suspected, especially in severe cases.Key words: Dengue, Chikungunya fever, coinfection, mortality, shock. Palabras clave: Dengue, Chikungunya, coinfección, mortalidad, síndrome de choque. IntroducciónE l virus Chikungunya (CHIK-V), del dengue (DEN-V) y más recientemente el virus Zika, son actualmente los arbovirus de mayor importancia médica. Durante los últimos años, estos virus se han extendido rápidamente por el mundo 1-3 . En la última década, la región de las Américas se ha convertido en un área hiperendémica para DEN-V. Esta situación se agravó desde el año 2014 por la llegada del CHIK-V, que se distribuyó por todo el Caribe, Centro y Sudamérica 4-7 . En Colombia, entre los años 2014 y 2015, se presentaron alrededor de 438.031 casos presuntivos de Chikungunya.El valle geográfico del río Cauca, en el suroccidente de Colombia, es una zona hiperendémica con alta transmisión del DEN-V (20% del total de casos de Colombia). Durante el período 2014 y 2015 se presentaron en la región alrededor de 122.857 casos presuntivos de Chikungunya 8 .Ambas infecciones (CHIK-V y DEN-V) comparten algunas manifestaciones clínicas, como la fiebre, calofríos, náuseas, vómitos, cefalea, y erupciones cutáneas. En una u otra infección pueden presentarse dolores articulares y dificultad para la movilización, de intensidad variable. La infección por CHIK-V se ha asociado a mayor compromiso articular [9][10] . Sin embargo, no se ha reportado casos de aumento de la permeabilidad capilar, síndromes de choque o hemorragias graves. En forma infrecuente se han descrito casos fatales con cuadros de encefalopatía, miocarditis y compromiso hepático 9,11 . El DEN-V, por el contrario, se asocia con cuadros clínicos graves, tales como el síndrome de fuga capilar y choque, manifestaciones hemorrágicas, compromiso visceral cardíaco y hepático, con mayor mortalidad 12,13 .Dado que los vectores son los mismos para ambos arbovirus (mosquitos Aedes aegypti y albopictus) la probabilidad biológica de una co-infección es real. Desde hace varios año...

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“…Se ha descrito la co-circulación del CHIKV y el DENV en la India, Malasia y Sri Lanka 9,11 . La co-infección entre estos dos virus se reportó en 1967 en India 16 .…”

Section: Discussionunclassified

unclassified

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Co-infección por virus del dengue (DEN-V) y virus Chikungunya (CHIK-V) durante un brote epidémico en Cali, Colombia: Comunicación de un caso fatal

Rosso

Pacheco

Rodríguez

et al. 2016

Rev. chil. infectol.

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“…In tropical countries including India, the chikungunya affected areas overlap with Dengue endemic areas and provide opportunities for mosquitoes to become infected with both viruses [76]. In areas, where both viruses cocirculate, they can be transmitted together causing co-infections with varied atypical clinical manifestations with frequent outbreak recurrence [77,78]. It is a major challenge to the health system in adopting or implementing vector and viral control activities via addressing the problems of water management.…”

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Environmental Health Monitoring: A Pragmatic Approach

Vincent¹

2014

Int J Waste Resources

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Eco benign environment, wherein human race survives and evolves, comprises the interaction of biotic and abiotic systems. Maintaining such environment in view of drastically changing human practices due to increased industrialization, urbanization and modernization is an urgent necessity for the global human community. The responsibility to protect the environment as well as to make it suitable for sustaining human life with well-being propels research-based implementation of best industrial and environmental practices. The nature of strategies and research designed for arriving eco-benign solutions to the challenges of environmental protection widely varies with different fields of industry. It is important to note that the intervention of environmental friendly strategies for making hazard and disease free environment is inevitable in all spheres of life, and the research on green solutions envisaged for management of environmental resources is the need of hour. Hence, in this review, we highlight three socially important environmental research areas such as impact of toxicity of metal pollutants in aquatic biological systems with special reference to fish as a bioindicator, mosquito control by bioinsecticides, and management of disease and disaster management by Geographical Information Systems (GIS) that are of our areas of contribution. Though these areas are viewed as different domains, they share an unique feature among themselves i.e. the crisis in water management affecting environment and health. The review also attempts to discuss about the possible biointervention solutions to address the challenges in water management in terms of pollution.Keywords: Metal toxicity; Aquatic health; Biomonitoring; Metallothionein; Bioinsecticides; GIS; Drainage Changing Quality of Aquatic LifeQuality of life in aquatic system is determined by the characteristics of biotic resources and their interactions that are complex and dynamic. Naturally, there is a self-balance between the biotic resources and their interactions both in quantitative and qualitative aspects and the balance is affected when new elements are introduced to the system. Especially, the elements introduced into the system have toxic properties; the aquatic system is under threat of quality degradation that seriously affects global biodiversity. Aquatic system today is polluted by industrial effluents comprising organic and synthetic chemical substances, heavy metals, dyes, oil etc; house hold wastes such as detergents and drainage; e-wastes, pesticides from agricultural lands, spillage of oil from ships etc. These pollutants of both biodegradable and non-biodegradable change the water qualities such as colour, odour, surface tension, thermal properties, conductivity, density, pH etc [1]. The acidic and alkali pollutants destroy most invertebrates and microorganisms [2]. Due to increased anthropogenic activities, aquatic organisms are continuously exposed to the elevated levels of metal concentration that the levels not previously encountered. ...

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Systematic analysis of disease‐specific immunological signatures in patients with febrile illness from Saudi Arabia

et al. 2020

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Objectives Little is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised. Methods A total of 2018 febrile patients from Jazan, Saudi Arabia, were recruited between 2014 and 2017. Patients were screened for dengue and chikungunya virus, Plasmodium, Brucella, Neisseria meningitidis, group A streptococcus and Leptospira. Clinical history and biochemical parameters from blood tests were collected. Patient sera of selected disease‐confirmed infections were quantified for immune mediators by multiplex microbead‐based immunoassays. Results Approximately 20% of febrile patients were tested positive for one of the pathogens, and they presented overlapping clinical and laboratory parameters. Nonetheless, eight disease‐specific immune mediators were identified as potential biomarkers for dengue (MIP‐1α, MCP‐1), malaria (TNF‐α), streptococcal and meningococcal (eotaxin, GRO‐α, RANTES, SDF‐1α and PIGF‐1) infections, with high specificity and sensitivity profiles. Notably, based on the conditional inference model, six of these mediators (MIP‐1α, TNF‐α, GRO‐α, RANTES, SDF‐1α and PIGF‐1) were revealed to be 68.4% accurate in diagnosing different febrile infections, including those of unknown diseases. Conclusions This study is the first extensive characterisation of the clinical analysis and immune biomarkers of several clinically important febrile infections in Saudi Arabia. Importantly, an immune signature with robust accuracy, specificity and sensitivity in differentiating several febrile infections was identified, providing useful insights into patient disease management in the Arabian Peninsula.

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A Comparative Study of Clinical Features between Monotypic and Dual Infection Cases with Chikungunya Virus and Dengue Virus in West Bengal, India

Cited by 75 publications

References 15 publications

Co-infección por virus del dengue (DEN-V) y virus Chikungunya (CHIK-V) durante un brote epidémico en Cali, Colombia: Comunicación de un caso fatal

Co-infección por virus del dengue (DEN-V) y virus Chikungunya (CHIK-V) durante un brote epidémico en Cali, Colombia: Comunicación de un caso fatal

Environmental Health Monitoring: A Pragmatic Approach

Systematic analysis of disease‐specific immunological signatures in patients with febrile illness from Saudi Arabia

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