Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas

Abstract

Welcher Weg ist der richtige? Die Produktverteilung der effizienten Oxidation von 2‐Aminoanthracen‐Derivaten zu Pyrazin‐ und Pyrrol‐verbrückte Bisanthracenen kann durch Additive kontrolliert werden (siehe Schema; TFA=Trifluoressigsäure, DDQ=2,3‐Dichlor‐5,6‐dicyano‐1,4‐benzochinon). Das Pyrrol‐verbrückte Dimer ist ein Aza[7]helicen mit stabiler helikaler Konformation.

Cytologic analyses of spindle‐cell lesions of the thorax and retroperitoneum

“…The significance of pleomorphism in the grading of spindle-cell lesions is expected. Jones et al 18 and Weir et al 29 also found a statistical association of atypia or pleomorphism with grade in their study of soft-tissue sarcomas. They found that cellular atypia best reflected high-grade mesenchymal lesions.…”

“…The patients might also receive neoadjuvant chemotherapy in some protocols. A similar treatment protocol is adopted at the University of Utah Medical Center in cases of adult soft-part sarcomas, as described by Jones et al 18 Therefore, the objective of the cytologic distinction of benign, low-grade, and high-grade spindle-cell lesions is to provide the clinician with useful information upon which the best therapeutic approach can be chosen. Indeed, Kilpatrick et al 27 reported that FNAB material was enough to initiate definitive therapy in 83% of soft tissue sarcomas.…”

“…This classification is similar to the one employed by Jones at al. 18 in their study of musculoskeletal sarcomas. Pleomorphism was classified as minimal or marked.…”

“…These findings should be meaningful, especially in mesenchymal tumors. Currently, the clinical management of mesenchymal tumors is based on the anatomic location and stage 18 and grade is an integral part of the staging system.…”

Update in management of head and neck sarcoma

“…In only 7% of cases were the FNA findings misleading (benign or inflammatory) and in 5% of cases the reading was interpreted as inadequate. More recently, Jones et al [19] identified that FNA biopsies of sarcoma were more often interpreted as showing a lower grade than that determined by final analysis of the fully resected specimen.…”