Concomitant (without Adjuvant) Temozolomide and Radiation to Treat Glioblastoma: a Retrospective Study

A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects

“…cervical cancer), low dose chemotherapy concurrently with radiotherapy has clearly been demonstrated to produce a radiosensitizing effect (Dubay et al, 2004;Keys et al, 1999;Rose et al, 1999). Furthermore, a recent retrospective clinical study of patients with GBM treated only with concurrent radiotherapy and TMZ, and omitting the adjuvant TMZ component, suggests that the concomitant rather A c c e p t e d m a n u s c r i p t 24 than the adjuvant phase is the most efficacious part, raising the question of the optimal timing of chemotherapy in the treatment of GBM (Sridhar et al, 2009). …”

Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme

“…19,65,71,87 It has been established that glioma cells under the assault of TMZ are arrested in G 2 /M phase of the cell cycle, hindering them from subsequent growth and division, 40,88,89 and rendering them sensitive to radiotherapy. 89 Tsien and colleagues 90 reported findings in their study using intensity modulated radiotherapy of 75 Gy in 30 fractions, resulting in a median OS of 20.1 months.…”

Multicentric gliomas misdiagnosed as metastatic tumors: One case report and literature review

“…In this opinion, they believed that extensive resection increases the risk of haemorrhage and neurological defi cit without infl uencing survival [7] . Concomitant chemotherapy and radiotherapy may have certain effects on glioblastoma, but they still need further trials [13,[17][18][19] . Some authors suggest that the surgical intervention for removing the gliomas is followed by a decompressive craniotomy because sometimes the tumor cannot be completely resected [20] .…”

“…Another method of Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MRI can be used to differentiate recurrent glioblastoma multiforme from radiation necrosis [13] . However, the diagnosis of their nature and differentiation from other pathological changes (i.e.…”