Concomitant uptake of antimicrobials and Salmonella in soil and into lettuce following wastewater irrigation

Sallach, J. Brett; Zhang, Yuping; Hodges, Laurie; Snow, Daniel D.; Li, Xu; Bartelt–Hunt, Shannon L.

doi:10.1016/j.envpol.2014.11.018

Cited by 36 publications

(32 citation statements)

References 56 publications

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“…to 4 × 10 7 ciprofloxacin-resistant bacteria, both of which are culturable per square meter of the soil daily. Sallach et al (2015) detected sulfamethoxazole in lettuce cultivated in a glasshouse and irrigated with artificial wastewater at concentrations ranging between 84 and 822 ng/g fresh weight. This shows that irrigation water serves as a potential transmission route of antibiotics, ARBs, and ARGs to farm produce, thus posing a risk to human health.…”

Section: Irrigation Watermentioning

confidence: 99%

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

2020

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The agricultural ecosystem creates a platform for the development and dissemination of antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the veterinary, agricultural, and medical sectors. This results in the selective pressure for the intrinsic and extrinsic development of the antimicrobial resistance phenomenon, especially within the aquaculture‐animal‐manure‐soil‐water‐plant nexus. The existence of antimicrobial resistance in the environment has been well documented in the literature. However, the possible transmission routes of antimicrobial agents, their resistance genes, and naturally selected antibiotic‐resistant bacteria within and between the various niches of the agricultural environment and humans remain poorly understood. This study, therefore, outlines an overview of the discovery and development of commonly used antibiotics; the timeline of resistance development; transmission routes of antimicrobial resistance in the agro‐ecosystem; detection methods of environmental antimicrobial resistance determinants; factors involved in the evolution and transmission of antibiotic resistance in the environment and the agro‐ecosystem; and possible ways to curtail the menace of antimicrobial resistance.

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Section: Irrigation Watermentioning

confidence: 99%

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

2020

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“…However, human exposure to antibiotics from the environment is possible via a number of pathways, including ingesting contaminated food and water and breathing in contaminated dust particles. Measurable levels of antibiotic uptake from growth media into crops have been shown for a variety of plant types, including carrots (Boxall et al, 2006), cucumber (Shenker et al, 2011), lettuce (Sallach et al, 2015), and rice (Boonsaner and Hawker, 2012). A variety of agricultural-use antibiotics have been detected in drinking water, including macrolides, quinolones, and sulfonamides (Ye et al, 2007;Benotti et al, 2009;Yiruhan et al, 2010).…”

Section: Effects On Human Healthmentioning

confidence: 99%

Antibiotics and Antibiotic Resistance in Agroecosystems: State of the Science

et al. 2016

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We propose a simple causal model depicting relationships involved in dissemination of antibiotics and antibiotic resistance in agroecosystems and potential effects on human health, functioning of natural ecosystems, and agricultural productivity. Available evidence for each causal link is briefly summarized, and key knowledge gaps are highlighted. A lack of quantitative estimates of human exposure to environmental bacteria, in general, and antibiotic-resistant bacteria, specifically, is a significant data gap hindering the assessment of effects on human health. The contribution of horizontal gene transfer to resistance in the environment and conditions that might foster the horizontal transfer of antibiotic resistance genes into human pathogens also need further research. Existing research has focused heavily on human health effects, with relatively little known about the effects of antibiotics and antibiotic resistance on natural and agricultural ecosystems. The proposed causal model is used to elucidate gaps in knowledge that must be addressed by the research community and may provide a useful starting point for the design and analysis of future research efforts.

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“…Plant uptake of antibiotics from soil has been shown to be both compound specific and plant dependent, with differences reported at the subspecies level (Sallach et al, 2015). Uptake into plants is thought to be dependent on partitioning in soil pore water (Carter et al, 2014), and translocation within the plant has been shown to correlate with ion speciation, both inside and outside of the plant (Dodgen et al, 2013;Trapp and Mc Farlane, 1995), as well as with the lipophilicity of individual compounds (Briggs et al, 1982;Hawker et al, 2013).…”

Section: Determining Occurrence Fate and Biological Effects Of Antimentioning

confidence: 99%

“…Thus, the ionization efficiency of demeclocyline may be affected slightly differently compared with the other tetracycline compounds. In addition, demeclocycline has been shown to epimerize in the presence of some complex matrices that may increase variability in peak integration (Sallach et al, 2015). Selection of internal standards in LC/MS/MS must consider chromatographic retention times, relative recoveries, and susceptibility to matrix effects.…”

Section: Isotope Dilution Mass Spectrometrymentioning

confidence: 99%

Challenges in the Measurement of Antibiotics and in Evaluating Their Impacts in Agroecosystems: A Critical Review

et al. 2016

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Large quantities of antibiotics are used in agricultural production, resulting in their release to agroecosystems through numerous pathways, including land application of contaminated manure, runoff from manure-fertilized fields, and wastewater irrigation of croplands. Antibiotics and their transformation products (TPs) exhibit a wide range of physico-chemical and biological properties and thus present substantive analytical challenges. Advances in the measurement of these compounds in various environmental compartments (plants, manure, soil, sediment, and water) have uncovered a previously unrealized landscape of antibiotic residues. These advanced multiresidue methods, designed to measure subng g -1 concentrations in complex mixtures, remain limited by the inherent intricacy of the sample matrices and the difficultly in eliminating interferences that affect antibiotic detection. While efficient extraction methods combined with high sensitivity analysis by liquid chromatography/mass spectrometry can provide accurate quantification of antibiotics and their TPs, measured concentrations do not necessarily reflect their bioavailable fractions and effects in the environment. Consequently, there is a need to complement chemical analysis with biological assays that can provide information on bioavailability, biological activity, and effects of mixtures. Enzyme-linked immunosorbent assays (ELISA), often used as screening tools for antibiotic residues, may be useful for detecting the presence of structurally related antibiotic mixtures but not their effects. Other tools, including bioreporter assays, hold promise in measuring bioavailable antibiotics and could provide insights on their biological activity. Improved assessment of the ecological and human health risks associated with antibiotics in agroecosystems requires continued advances in analytical accuracy and sensitivity through improvements in sample preparation, instrumentation, and screening technologies.

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Concomitant uptake of antimicrobials and Salmonella in soil and into lettuce following wastewater irrigation

Cited by 36 publications

References 56 publications

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

Antibiotics and Antibiotic Resistance in Agroecosystems: State of the Science

Challenges in the Measurement of Antibiotics and in Evaluating Their Impacts in Agroecosystems: A Critical Review

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