Concentrations of Insulin-Like Growth Factor-I in Blood and Ovarian Follicular Fluid of Cattle Selected for Twins1

Echternkamp, S. E.; Spicer, L. J.; Gregory, K. E.; Canning, Sandra F.; Hammond, James M.

doi:10.1095/biolreprod43.1.8

Cited by 208 publications

(107 citation statements)

References 32 publications

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“…An increase in the total IGF1 concentration under circulating levels of high E 2 and nadir P 4 after selection of co-dominance in the CL-absent cows is similar to an increase in the circulating total IGF1 at the follicular phase during the bovine oestrous cycle (Kawashima et al 2007b). In addition, Echternkamp et al (1990) reported that cattle selected for the birth of twins have a greater IGF1 concentration than cattle not selected for such a birth. It has been reported that bovine liver expresses mRNA for E 2 receptor, but not P 4 receptor (Pfaffl et al 2002).…”

Section: Discussionmentioning

confidence: 99%

The absence of corpus luteum formation alters the endocrine profile and affects follicular development during the first follicular wave in cattle

Hayashi¹,

Matsui²,

Shimizu³

et al. 2008

Reproduction

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We previously established a bovine experimental model showing that the corpus luteum (CL) does not appear following aspiration of the preovulatory follicle before the onset of LH surge. Using this model, the present study aimed to determine the profile of follicular development and the endocrinological environment in the absence of CL with variable nadir circulating progesterone (P 4 ) concentrations during the oestrous cycle in cattle. Luteolysis was induced in heifers and cows and they were assigned either to have the dominant follicle aspirated (CL-absent) or ovulation induced (CL-present). Ultrasound scanning to observe the diameter of each follicle and blood collection was performed from the day of follicular aspiration or ovulation and continued for 6 days. The CL-absent cattle maintained nadir circulating P 4 throughout the experimental period and showed a similar diameter between the largest and second largest follicle, resulting in co-dominant follicles. Oestradiol (E 2 ) concentrations were greater in the CL-absent cows than in the CL-present cows at day K1, day 1 and day 2 from follicular deviation. The CL-absent cows had a higher basal concentration, area under the curve (AUC), pulse amplitude and pulse frequency of LH than the CL-present cows. After follicular deviation, the CL-absent cows showed a greater basal concentration, AUC and pulse amplitude of growth hormone (GH) than the CL-present cows. These results suggest that the absence of CL accompanying nadir circulating P 4 induces an enhancement of LH pulses, which involves the growth of the co-dominant follicles. Our results also suggest that circulating levels of P 4 and E 2 affect pulsatile GH secretion in cattle.

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Section: Discussionmentioning

confidence: 99%

The absence of corpus luteum formation alters the endocrine profile and affects follicular development during the first follicular wave in cattle

Hayashi¹,

Matsui²,

Shimizu³

et al. 2008

Reproduction

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“…For the insulin quality control sera the intra-assay CVs were 3.4, 3.9 and 8.0% for high, medium and low sera respectively. Serum concentrations of IGF-I were determined using a RIA following acid-ethanol extraction using a modification of the assay previously described by Echternkamp et al 1990.…”

Section: Metabolic and Hormonal Parametersmentioning

confidence: 99%

“…Recombinant IGF-I (Upstate, Millipore, Temecula, CA, USA) was iodinated using a chloramine T and sodium metabisulphite method as described previously (Spicer et al 1988, Echternkamp et al 1990. Recombinant human IGF-I (Upstate, Millipore, Temecula, CA, USA) was used to generate the standard curve.…”

Section: Metabolic and Hormonal Parametersmentioning

confidence: 99%

Characterisation of endometrial gene expression and metabolic parameters in beef heifers yielding viable or non-viable embryos on Day 7 after insemination

Beltman

Forde

Furney

et al. 2010

Reprod. Fertil. Dev.

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Abridged title: Endometrial gene expression and metabolic parameters in subfertile beef heifers. AbstractThe objective of this study was to compare the hormonal, metabolic characteristics and endometrial gene expression profiles in beef heifers yielding either a viable or a degenerate embryo on Day 7 after insemination as a means to explain differences in embryo survival.Oestrus was synchronised in cross bred beef heifers (n=145) using a CIDR-prostaglandin protocol and heifers (n=102) detected in standing oestrus (within 24-48 h post CIDR removal) were inseminated 12-18 h after detection of oestrus (Day 0) with frozen-thawed semen from a single ejaculate of a bull with proven fertility. Blood samples were collected from Day 4 to Day 7 post oestrus to measure progesterone (on Days 4, 5 and 7), insulin and IGF-I (on Days 4 and 6) and urea concentrations (on Day 7). All animals were slaughtered on Day 7. Uterine pH was also determined. Animals from which an embryo was recovered were classified as either having a viable embryo (morula/blastocyst stage); n=32, or a retarded embryo (arrested at 2-to 16-cell stage); n=19. The overall recovery rate was 64%. There was no significant difference in blood parameters measured or uterine pH at slaughter between the heifers with either a viable or retarded embryo. The relative abundance of 9 transcripts out of 53 tested from the endometrial tissue was different between heifers with a viable embryo or retarded embryo: MOGAT1, PFKB2, LYZ2, SVS8, UHRF1, PTGES, AGPAT4, DGKA and HGPD. Both LYZ2 and UHRF1 are associated with regulation of the immune system. PFKFB2 is a mediator in glycolysis and MOGAT, AGPAT4 and DGKA belong to the triglyceride synthesis pathway. PTGES and HGPD belong to the prostaglandin pathway.Both of these metabolic pathways are important for early embryonic development. In conclusion, retarded embryo development in this study was not related to serum progesterone, IGF-I, insulin or urea concentrations nor to uterine pH at slaughter. However, altered expression of genes involved in the prostaglandin and triglyceride pathways, as well as 2 genes that are closely associated with the regulation of immunity in the endometrium may indicate a uterine component to the retardation of the embryos in these beef heifers.

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“…It is also unclear, whether a high systemic IGF-I concentration always favors reproduction, because studies in mice revealed that instead of systemically produced IGF-I, locally produced IGF-I may be more important for the stimulation of the ovary [62]. This may be important, because the size of the follicle is important for the extent to which follicular IGF-I reflects the systemic concentration of IGF-I [31].…”

Section: A Role For Insulin and Igf-i On Ovarian Functionmentioning

confidence: 99%

Metabolic changes in early lactation and impaired reproductive performance in dairy cows

Jorritsma

Wensing

Kruip³

et al. 2003

Vet. Res.

198

162

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-This review addresses the suggestion that the decline in dairy reproductive performance, as increasingly observed these days, may be due to a hampered process of metabolic adaptation in early lactating cows. In our opinion, adaptation to the negative energy balance is a gradual process. Because almost all cows do adapt in the long run, it is not possible to classify animals as adapted or non-adapted. The use of risk factors is more appropriate in this case and is discussed in this review. Among them are the body condition score and its derivatives, feed intake, the calculated negative energy balance, and metabolic parameters like the plasma concentration of insulin or the triacylglycerol content in the liver. Moreover, factors that play a role in the link between declined reproductive performance and the metabolic situation of the cow during the early lactating period are discussed. Among these are insulin, insulin-like growth factors, leptin, neuropeptide Y, nonesterified fatty acids, thyroïd hormones, urea, and ammonia. fertility / dairy / periparturient metabolic adaptation / physiopathology / periparturition

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Concentrations of Insulin-Like Growth Factor-I in Blood and Ovarian Follicular Fluid of Cattle Selected for Twins1

Cited by 208 publications

References 32 publications

The absence of corpus luteum formation alters the endocrine profile and affects follicular development during the first follicular wave in cattle

The absence of corpus luteum formation alters the endocrine profile and affects follicular development during the first follicular wave in cattle

Characterisation of endometrial gene expression and metabolic parameters in beef heifers yielding viable or non-viable embryos on Day 7 after insemination

Metabolic changes in early lactation and impaired reproductive performance in dairy cows

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