Concentration of Lactoferrin and Transferrin throughout Lactation in Cow’s Colostrum and Milk

Sánchez, Lourdes; Aranda, Paloma; Perez, M. Dolores; Calvo, Miguel

doi:10.1515/bchm3.1988.369.2.1005

Cited by 110 publications

(60 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As cow milk is the major industrial source of serum proteins, this result is particularly interesting because sheep milk may be a new and more profitable source of whey protein. The LF was higher than the values observed in sheep (Qian et al, 1995), cow (Sanchez et al, 1988) and goat milk (Greppi and Roncada, 2001). The IG and SA concentrations were also higher than those previous reported for sheep (Duranti and Casoli, 1991;Law, 1995), cows and goats (Law, 1995).…”

Section: Discussioncontrasting

confidence: 52%

Effects of lactation stage, parity, β-lactoglobulin genotype and milk SCC on whey protein composition in Sarda dairy ewes

Nudda

Feligini

Battacone

et al. 2003

Italian Journal of Animal Science

View full text Add to dashboard Cite

In 90 Sarda dairy ewes the effects of lactation stage, parity, β-lactoglobulin genotypes, and somatic cell count (SCC) on the milk content of total protein (TP), casein (CN), whey protein (WP) and its fractions α-lactalbumin (ALA), β-lactoglobulin (BLG), serum albumin (SA), immunoglobulin (IG) and lactoferrin (LF) were analysed using a linear mixed model. Mean values of variables (g/l) were: TP (54.0), CN (43.0), WP (11.0), BLG (4.78), ALA (1.37), SA (0.61), IG (3.83) and LF (0.28). The lactation stage significantly affected all the variables analysed. TP, CN and WP concentrations tended to increase throughout lactation, with the increase of WP being more pronounced than the corresponding variation in CN. There was no definite trend in BLG content, whereas ALA concentration decreased as lactation progressed. The parity affected almost all variables studied. WP concentration differed significantly only between the second and fourth parity (10.45 vs 11.44 g/l). BLG and SA concentrations were significantly lower in the youngest ewes. The BLG genotype affected milk yield, but no effects were observed on the components of the milk. The SCC influenced almost all variables studied. The TP concentration was significantly higher in milk with SCC >1,000,000 (55.0 g/l) than in milk with lower SCC (53.4 g/l). This was mainly due to the increase of WP (12.52 and 10.24 g/l in milk with SCC above and below 1,000,000/ml respectively), especially in those WP fractions originating from blood. TP (54,0), CN (43,0), WP (11,0), BLG (4,8), ALA (1,4), SA (0,61), IG (3,83) e LF (0,28

show abstract

Section: Discussioncontrasting

confidence: 52%

Effects of lactation stage, parity, β-lactoglobulin genotype and milk SCC on whey protein composition in Sarda dairy ewes

Nudda

Feligini

Battacone

et al. 2003

Italian Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…However, it is important to realize that a systemic distribution of LfcinB at the concentration (200 g/ml) that showed antiangiogenic activity in our in vivo and in vitro assays cannot be attained by the normal consumption of dairy products containing bovine lactoferrin as a source of LfcinB because cow's milk, for example, contains less than 100 mg/L lactoferrin. 40 Endothelial cell proliferation and migration are important components of the angiogenic process, which is normally tightly regulated by a balance of pro-and antiangiogenic factors, but may become dysregulated under pathological conditions such as tumor growth. 3 Growth factors that promote angiogenesis include bFGF and VEGF 165 , 6,7 both of which are produced by neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Bovine Lactoferricin Inhibits Basic Fibroblast Growth Factor- and Vascular Endothelial Growth Factor165-Induced Angiogenesis by Competing for Heparin-Like Binding Sites on Endothelial Cells

Mader

Smyth

Marshall

et al. 2006

The American Journal of Pathology

View full text Add to dashboard Cite

“…Influx of leukocytes can also be induced by intramammary treatment with PBS [4,20]. The influx in which neutrophil leukocytes predominate, culminates within 24 h. Mammary gland injury is resolved after 72 to 96 h and the major role is played by apoptosis and phagocytosis of apoptotic neutrophils by mononuclear phagocytes [23,24].…”

Section: Discussionmentioning

confidence: 99%

Activation of phagocytes during initiation and resolution of mammary gland injury induced by lipopolysaccharide in heifers

Sládek¹,

Rysanek²,

Faldyna

2002

Vet. Res.

View full text Add to dashboard Cite

-The object of the study was the comparative assessment of phagocyte activation during initiation and resolution of mammary gland injury induced by lipopolysaccharide (LPS) or buffered salt solution (PBS) on the basis of the CD14 receptor positivity. The experiments were carried out in 15 clinically normal Holstein × Bohemian Red Pied crossbred heifers, aged 14 to 18 months. Noninflammatory and inflammatory mammary gland injury were induced by intramammary administration of PBS (10 mL) and LPS (10 mL, 1 µg/mL), respectively. Samples of the cell populations were obtained by mammary lavages at 24 h intervals. Flow cytometry was used to determine the CD14+ neutrophils, monocytes, and macrophages. The percentage of CD14+ neutrophils was only 1.2% and 1.3% 24 h after the treatment with PBS and LPS, respectively. The resolution was accompanied by an increase in proportion of CD14+ neutrophils. The proportion of CD14+ neutrophils returned to initial values in the PBS-treated, but not in the LPS-treated mammary glands till 96 h. Percentage of CD14+ monocytes increased after 24 h and the effect was more pronounced in the LPS-treated than in the PBS treated mammary glands (P < 0.05). The percentage of CD14+ macrophages decreased highly significantly at 24 h in the LPS-treated, but not in the PBS-treated mammary glands (P < 0.01). The resolution of mammary gland injury (48 to 96 h) was characterised by an increase in CD14+ macrophages proportion, which was greater in the LPS-treated than PBS-treated mammary glands (P < 0.01). The activation of macrophages during resolution of mammary gland injury can be interpreted as an important mechanism of restitution. Résumé -Activation des phagocytes au cours de l'initiation et de la résolution de lésion de la glande mammaire induite par des lipopolysaccharides chez des génisses. L'objet de la présente étude est l'analyse de l'activation des phagocytes au cours de l'initiation et de la résolution de lésion de la glande mammaire induite par des lipopolysaccharides (LPS), ou par la solution physiologique (PBS), et cela sur la base de la positivité du CD14 récepteur. L'essai fut réalisé sur 15 génisses, cliniquement en bonne santé, issues du croisement des races Holstein × Pie rouge tchèque, âgées de 14 à 18 mois. Des lésions non-inflammatoires et inflammatoires de la glande mammaire ont été induites par l'administration intra-mammaire de PBS (10 mL) et LPS (10 mL, 1 µg/mL), respectivement. Les échantillons de populations cellulaires ont été obtenus par lavage des glandes mammaires, à des intervalles de 24 heures. On a utilisé la cytométrie de flux pour détecter les neutrophiles, les monocytes et les macrophages CD14+. Pendant l'induction de la lésion de glande mammaire (24 h), on a détecté seulement 1,2 % des neutrophiles CD14+ après traitement par le PBS et 1,3 % après traitement par le LPS. La résolution fut caractérisée par une augmentation de la proportion de neutrophiles CD14+. Jusqu'à 96 heures, après injection de PBS, à la différence de celle de LPS, la proportion de ne...

show abstract

Concentration of Lactoferrin and Transferrin throughout Lactation in Cow’s Colostrum and Milk

Cited by 110 publications

References 3 publications

Effects of lactation stage, parity, β-lactoglobulin genotype and milk SCC on whey protein composition in Sarda dairy ewes

Effects of lactation stage, parity, β-lactoglobulin genotype and milk SCC on whey protein composition in Sarda dairy ewes

Bovine Lactoferricin Inhibits Basic Fibroblast Growth Factor- and Vascular Endothelial Growth Factor165-Induced Angiogenesis by Competing for Heparin-Like Binding Sites on Endothelial Cells

Activation of phagocytes during initiation and resolution of mammary gland injury induced by lipopolysaccharide in heifers

Contact Info

Product

Resources

About