Bovine Lactoferricin Inhibits Basic Fibroblast Growth Factor- and Vascular Endothelial Growth Factor165-Induced Angiogenesis by Competing for Heparin-Like Binding Sites on Endothelial Cells

Mader, Jamie S.; Smyth, Daniel; Marshall, Jean S.; Hoskin, David W.

doi:10.2353/ajpath.2006.051229

Cited by 76 publications

(56 citation statements)

References 53 publications

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“…In addition, phase II clinical trials with the tea polyphenol EGCG have shown diminished oxidative DNA damage in individuals at high risk for liver cancer (31). Furthermore, downregulation of cell cycle, tumour invasion and angiogenesis related proteins by bLF and P-B combination seen in the present study is in line with the anticarcinogenic properties of bLF and tea polyphenols documented by us and other workers (8,(32)(33)(34)(35).…”

Section: Discussionsupporting

confidence: 91%

In Vitro Antioxidative Potential of Lactoferrin and Black Tea Polyphenols and Protective Effects In Vivo on Carcinogen Activation, DNA Damage, Proliferation, Invasion, and Angiogenesis During Experimental Oral Carcinogenesis

Letchoumy¹,

Mohan²,

Stegeman³

et al. 2008

oncol res

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Objective-The present study was designed to evaluate the in vitro antioxidant potential of bovine lactoferrin (bLF) and black tea polyphenol (Polyphenon-B; P-B) as well as in vivo inhibitory effects on the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinomas.Design-Antioxidant activity was screened using a panel of assays including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), hydroxyl radical anion (OH • ), superoxide anion (O 2•− ), and nitric oxide (NO) radical scavenging assays as well as assay for reducing power. The chemopreventive potential of bLF and P-B was assessed in the HBP model based on the modulatory effects on DMBA-induced oxidative DNA damage as well as the expression of proteins associated with carcinogen activation (CYP1A1, CYP1B1), cell proliferation (cyclin D1, proliferating cell nuclear antigen; PCNA, glutathione S-transferase pi; GST-P), angiogenesis (vascular endothelial growth factor; VEGF, VEGF receptor 1; VEGFR1), and invasion and metastasis (matrix metalloproteinase-9; MMP-9 and tissue inhibitors of MMP-2; TIMP-2).Results-Both bLF and P-B showed high radical scavenging activity and reductive potential. Although administration of bLF and P-B alone suppressed DMBA-induced HBP tumors, combined administration of bLF and P-B was more effective in inhibiting HBP carcinogenesis by inhibiting oxidative DNA damage, carcinogen activation, cell proliferation, invasion and angiogenesis.Conclusion-Our study suggests that the antioxidative property of bLF and P-B may be responsible for chemoprevention of HBP carcinogenesis by modulating multiple molecular targets.

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Section: Discussionsupporting

confidence: 91%

In Vitro Antioxidative Potential of Lactoferrin and Black Tea Polyphenols and Protective Effects In Vivo on Carcinogen Activation, DNA Damage, Proliferation, Invasion, and Angiogenesis During Experimental Oral Carcinogenesis

Letchoumy¹,

Mohan²,

Stegeman³

et al. 2008

oncol res

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“…Interestingly, angiostatin can inhibit basic fibroblast growth factor (bFGF)-induced angiogenesis in vivo and bFGF-induced endothelial cell proliferation in vitro [11]. bFGF is normally sequestered in the extracellular matrix of healthy tissues [12] and expressed in many human cancer cells [13]. As a principal soluble stimulator of angiogenesis, it is believed to be important for the formation of tumors [14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Macrophage Metalloelastase on the Basic Fibroblast Growth Factor Expression and Tumor Angiogenesis in Murine Colon Cancer

Shi

Qiao

et al. 2011

Dig Dis Sci

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“…The LM␣5 (laminin ␣5)-derived peptide A5G27 binds to the glycosaminoglycan chains of CD44, preventing its binding to FGF2 and inhibiting angiogenesis [137]. The heparin-binding lactoferrin fragment LfcinB inhibits the angiogenic activity of FGF2 by binding to HSPGs on endothelial cells [138]. Protamine [139], several CXCL4-derived peptides, the histidine-rich glycoprotein [140] and antithrombin [141] exhibit antiangiogenic properties, whose mechanism of action may rely, at least in part, on their capacity to bind and mask HSPGs to FGFs.…”

Section: Preventing Fgf/fgfr/co-receptor Interactionsmentioning

confidence: 99%

Blocking the FGF/FGFR system as a ⿿two-compartment⿿ antiangiogenic/antitumor approach in cancer therapy

Giacomini

Chiodelli

Matarazzo

et al. 2016

Pharmacological Research

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a b s t r a c tFibroblast growth factors (FGFs) are a family of pleiotropic factors produced by stromal and parenchymal tumor cells. Even though FGFs have been firstly characterized as angiogenic factors, they exert autocrine and paracrine functions not only on endothelial cells but also on tumor cells and other stromal components. Thus, the FGF/FGF receptor (FGFR) pathway may represent a key player in tumor growth by regulating the complex cross-talk between stromal and tumor compartments.The ligand dependent or independent activation of the FGF/FGFR system by gene upregulation, oncogenic mutation or amplification occurs in a variety of human tumors and is implicated in various key steps of tumor growth and progression. In addition, FGF/FGFR activation has been described as a mechanism of tumor escape in response to antiangiogenic/anti-VEGF therapies.Experimental and clinical evidences provide a compelling biologic rationale for the development of anti-FGF/FGFR targeting agents in cancer therapy. However, the development of drugs specifically targeting the FGF/FGFR pathway proved to be difficult, also due to the high redundancy and pleiotropic effects of FGF and FGFR family members. On the other hand, the possibility to develop "two-compartment" targeting agents endowed with both antiangiogenic and antitumor activities remains promising.Here we will review the preclinical and clinical approaches and potential therapeutics currently available to block the FGF/FGFR system in human cancer.

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Bovine Lactoferricin Inhibits Basic Fibroblast Growth Factor- and Vascular Endothelial Growth Factor165-Induced Angiogenesis by Competing for Heparin-Like Binding Sites on Endothelial Cells

Cited by 76 publications

References 53 publications

In Vitro Antioxidative Potential of Lactoferrin and Black Tea Polyphenols and Protective Effects In Vivo on Carcinogen Activation, DNA Damage, Proliferation, Invasion, and Angiogenesis During Experimental Oral Carcinogenesis

In Vitro Antioxidative Potential of Lactoferrin and Black Tea Polyphenols and Protective Effects In Vivo on Carcinogen Activation, DNA Damage, Proliferation, Invasion, and Angiogenesis During Experimental Oral Carcinogenesis

Effects of Macrophage Metalloelastase on the Basic Fibroblast Growth Factor Expression and Tumor Angiogenesis in Murine Colon Cancer

Blocking the FGF/FGFR system as a ⿿two-compartment⿿ antiangiogenic/antitumor approach in cancer therapy

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