Computer program for the determination of salicylic acid content in aspirin by derivative spectrometry

Dumitrescu, V.; Surmeian, Mariana; Doneanu, Catalin E.; Stanescu, Sinziana

doi:10.1016/0003-2670(96)00201-2

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Taking into account Scheme 1 , we think that the different behavior of the PL spectra of ASA and ASE, during the exposure to UV light, originated also in a phototautomerization process of SAL [ 41 ], a compound, which in the commercial drugs, there is up to 0.1% [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Daescu

Iota

Serbschi³

et al. 2021

IJMS

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Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was reported. By exposure of the solution of ASA 0.3 M to UV light, a decrease in the PL band intensity was highlighted. This behavior was revealed for ASA in the presence of phosphate buffer (PB) having the pH equal to 6.4, 7, and 8 or by the interaction with NaOH 0.3 M. A different behavior was reported in the case of ASE. In the presence of PB, an increase in the intensity of the PL band of ASE simultaneously with a change of the ratio between the intensities of the bands at 361–364 and 394–397 nm was highlighted. The differences between PL spectra of ASA and ASE have their origin in the presence of salicylic acid (SAL). The interaction of ASE with NaOH induces a shift of the PL band at 405–407 nm. Arguments for the reaction of ASA with NaOH are shown by Raman scattering and FTIR spectroscopy.

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Section: Resultsmentioning

confidence: 99%

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Daescu

Iota

Serbschi³

et al. 2021

IJMS

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“…The acid and its salts (salicylates) occur naturally in many plants; concentrated sources include willow bark and oil of wintergreen. Various pharmacopeias (6) recommend that the maximum limit of SA in aspirin should be 0.1%.…”

Section: Introductionmentioning

confidence: 99%

Application of a lanthanide composite nanoparticle‐sensitized luminescence method for the determination of salicylic acid in pharmaceutical formulations and human plasma

2008

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Terbium-acetylacetone (Tb-acac) composite nanoparticles were synthesized using the ultrasonic method. The nanoparticles are water-soluble, stable and have extremely narrow emission bands and high internal quantum efficiencies. -4 mol/LSA was 1.75%. The method was applied to the determination of SA in pharmaceutical formulations and human plasma. We believe that the proposed approach has great potential for clinical purposes.

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“…Ultraviolet derivative spectrometry [8,9] has been applied successfully in pharmaceutical analysis for the determination of drugs in the presence of their degradation products [10,11] and the analogs of related impurity or impurities in the presence of the drug [12] .…”

Section: Introductionmentioning

confidence: 99%