Application of a lanthanide composite nanoparticle‐sensitized luminescence method for the determination of salicylic acid in pharmaceutical formulations and human plasma

Abstract

Terbium-acetylacetone (Tb-acac) composite nanoparticles were synthesized using the ultrasonic method. The nanoparticles are water-soluble, stable and have extremely narrow emission bands and high internal quantum efficiencies. -4 mol/LSA was 1.75%. The method was applied to the determination of SA in pharmaceutical formulations and human plasma. We believe that the proposed approach has great potential for clinical purposes.

Simultaneous Determination of 14 Phenolic Compounds in Grape Canes by HPLC-DAD-UV Using Wavelength Switching Detection

“…HPLC typically hyphenated with ultraviolet visible (UV), photodiode array (DAD), mass spectrometry (MS), electrochemical (ED), fluorescence (FD), chemiluminescence (CL), refractive index (RI), and evaporative light scattering (ELSD) detectors has been the best method of choice for routine analysis of phenolic compounds in most hitherto published studies. However, in many cases, the disadvantages of some detectors were their limited analytical application because of baseline drift, limitations of detecting electrochemically inactive compounds (ED), complex pretreatment of non-fluorescent analytes (FD), fewer chemiluminescence reactions available, interference from excess use of some derivation reagents, incompatibility of the mobile phase with chemiluminescence reactions (CL) and low sensitivity (RI, ELSD) [17,18,19,20,21,22,23,24]. The critical decision for the analyst of which analytical technique to employ, is not only dependent on the expected composition of the sample and the designation of analytical expectations, but also certainly on the instrument availability.…”

Simultaneous Determination of Saccharine, Caffeine, Salicylic Acid and Benzoic Acid in Different Matrixes by Salt and Air-Assisted Homogeneous Liquid-Liquid Extraction and High-Performance Liquid Chromatography

“…Class VP-LC workstation was employed to acquire and process chromatographic data. A reversed-phase C 18 analytical column (Shim-Pack VP-ODS, 250 mm × 4.6 mm i.d., 5 μm, Shimadzu, Japan) was used.…”

“…In order to extraction and quantification of these compounds different sample preparation techniques and detection systems were used [10][11][12][13][14][15][16][17] . Also, many methods have been reported for the determination of salicylic acid individually and in combination with other compounds in various matrixes using different analytical methods such as spectrophotometry, luminescence and HPLC [18][19][20][21][22] . In most of these methods samples were prepared using LLE or solid-phase extraction (SPE) techniques.…”

Application of Tb4O7 Nanoparticles for Lasalocid and Salicylate Determination in Food Analysis

“…The huge impact of nanotechnology in the analytical field has given rise to the development of luminescent lanthanide nanoparticles (NPs) based on the incorporation of a luminescent lanthanide chelate into organic polymer NPs, such as polystyrene NPs, or inorganic NPs, such as silica, zirconia, or titania NPs . Composite Tb(III)–acetylacetonate NPs have been used as reagents for the determination of salicylate (SAL) in pharmaceutical formulations and human plasma, obtaining a detection limit of 3.5 ng mL –1 . The method involves an energy transfer process between SAL and the composite NPs, because of the spectral overlap between the fluorescence spectrum of SAL and the excitation spectrum of the NPs.…”