Computed Tomographic Diagnosis of Myocardial Fat Deposits in Sarcoidosis

Abstract

Sarcoid patients demonstrate a higher chance of having LV fat deposits with a characteristic bulky morphology.

PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat

“…The ventricular fat has been observed in numerous pathologies, such as arrhythmogenic right ventricular cardiomyopathy (ARVC) (Austin et al, 2019), myocardial infarction and ischemia (Baroldi et al, 1997;Carpenter, 1962;Fontaine et al, 1999;Su et al, 2004), cardiac fibrosis (Li et al, 2019;Wang et al, 2018Wang et al, , 2019Wu et al, 2017), dilated cardiomyopathy (Lu et al, 2013), tuberous sclerosis, muscular dystrophy (Kimura et al, 2010), sarcoidosis (Saremi et al, 2015), and Proteus syndrome (Hannoush et al, 2015). Understanding the origin of adipocytes in cardiovascular diseases would 12 Cell Reports 34, 108697, February 2, 2021 Article ll OPEN ACCESS provide some clues for the studies of pathophysiological processes of cardiovascular diseases.…”