Ventricular Myocardial Fat: An Unexpected Biomarker for Long-term Survival?

Bader, Anna S.; Levsky, Jeffrey M.; Zalta, Benjamin; Shmukler, Anna; Gohari, Arash; Jain, Vineet R.; Chernyak, Victoria; Lovihayeem, Michael; Bellin, Eran; Haramati, Linda B.

doi:10.1007/s00330-018-5546-4

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Lipomatous metaplasia is the phenomenon of conversion of non-adipose mesenchymal cells into mature lipocytes. Major examples of lipomatous metaplasia are seen in a myocardial scar after an ischemic heart disease, 1 as well as in salivary gland and adrenal tumors. 2,3 It has been described that non-adipose mesenchymal cells can also achieve adipocytic differentiation under certain circumstances in cardiac, kidney, and periarterial tissues.…”

Section: Introductionmentioning

confidence: 99%

Intradermal Band-like Lipomatous Metaplasia Can Be Associated With the Regression of Overlying Skin Neoplasms: A Clinicopathologic Study of 20 Cases

Takai

Murata

Goto

2020

The American Journal of Dermatopathology

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Lipomatous metaplasia has been rarely reported in both neoplastic and inflammatory dermatological disorders. Most neoplastic cases show the lipomatous change within the tumor silhouette, but band-like lipomatous metaplasia in the dermis under tumors has not been well-described. The aim of this study was to reveal the characteristics and relationship of intradermal band-like lipomatous metaplasia and coexisting skin tumors. A total of 20 cases with intradermal band-like lipomatous metaplasia were retrieved from 10,992 archive cases between April 1997 and March 2020 at Hyogo Cancer Center, and subjected to a detailed clinicopathologic analysis. Nine (45%) patients had superficial variant basal cell carcinoma as a coexisting neoplasm. Eight (40%) patients had squamous cell carcinoma, 5 of which were in situ. The remaining 3 (15%) cases were invasive extramammary Paget disease. All 20 cases showed at least one of 3 signs of tumor regression, namely, partial loss of overlying neoplasia, significant inflammatory infiltrate under the tumor, and fibrosis around the tumor. We concluded that intradermal band-like lipomatous metaplasia could be seen in association with the regressing process of cutaneous superficially-spreading neoplasms.

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Section: Introductionmentioning

confidence: 99%

Intradermal Band-like Lipomatous Metaplasia Can Be Associated With the Regression of Overlying Skin Neoplasms: A Clinicopathologic Study of 20 Cases

Takai

Murata

Goto

2020

The American Journal of Dermatopathology

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“…Direct evidence on the link between myocardial fat and prognosis is uncertain. Bader et al showed that myocardial fat in non-contrast chest CTs was associated with improved survival in patients regardless of history of MI ( 103 ), whereas Hata et al demonstrated its association with accelerated LV dysfunction ( 104 ). However, Batal et al did not find any significant association between myocardial fat and LV ejection fraction or survival ( 97 ).…”

Section: Discussionmentioning

confidence: 99%

Opportunistic screening at chest computed tomography: literature review of cardiovascular significance of incidental findings

Canan,

Ghandour,

Saboo

et al. 2023

Cardiovasc Diagn Ther

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Background and Objective Several incidental cardiovascular findings are present in a routine chest computed tomography (CT) scan, many of which do not make it to the final radiology report. However, these findings have important clinical implications, particularly providing prognosis and risk-stratification for future cardiovascular events. The purpose of this article is to review the literature on these incidental cardiovascular findings in a routine chest CT and inform the radiologist on their clinical relevance. Methods A time unlimited review of PubMed and Web of Science was performed by using relevant keywords. Articles in English that involved adults were included. Key Content and Findings Coronary artery calcification (CAC) is the most common incidental cardiac finding detected in a routine chest CT and is a significant predictor of cardiovascular events. Noncoronary vascular calcifications in chest CT include aortic valve, mitral annulus, and thoracic aortic calcifications (TAC). Among these, aortic valve calcification (AVC) has the strongest association with coronary artery disease and cardiovascular events. Additional cardiac findings such as myocardial scar and left ventricular size and noncardiac findings such as thoracic fat, bone density, hepatic steatosis, and breast artery calcifications can also help in risk stratification and patient management. Conclusions The radiologist interpreting a routine chest CT should be cognizant of the incidental cardiovascular findings, which helps in the diagnosis and risk-stratification of cardiovascular disease. This will guide appropriate referral and management.

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“…The prevalence of LM is low in patients with chronic ischemia, 21 intermediate in postinfarct patients, with incidence between 22% and 68%, 14,15,19,20,35,46 and high in patient with prior MI and VT, with incidence between 64% and 100%. 3,6,10 The incidence of LM appears to be closely associated with disease severity 2,47 but its measurement may be confounded by different image modalities, CMR sequences, and image settings.…”

Section: Lm Prevalence In Postinfarct Patientsmentioning

confidence: 96%

“…15,19 Ventricular aneurysms are also closely associated with LM. 2,18,21 LM has been reported to predict adverse outcomes, 6,48 while Bader et al 46 reported an opposite observation, possibly due to confouding by survival bias and underestimation of the LM incidence in the positive outcome group, considering that NCCT images with various slice thicknesses up to 5 mm or more were used, and LM was only identified by visual inspection.…”

Section: Lm Prevalence In Postinfarct Patientsmentioning

confidence: 99%

Noninvasive Assessment of Lipomatous Metaplasia as a Substrate for Ventricular Tachycardia in Chronic Infarct

Desjardins

Witschey

et al. 2023

Circ: Cardiovascular Imaging

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Myocardial lipomatous metaplasia (LM) has been increasingly reported in patients with prior myocardial infarction. Cardiac magnetic resonance and cardiac contrast-enhanced computed tomography have been used to noninvasively detect and quantify myocardial LM in postinfarct patients, and may provide useful information for understanding cardiac mechanics, arrhythmia susceptibility, and prognosis. This review aims to summarize the advantages and disadvantages, clinical applications, and imaging features of different cardiac magnetic resonance sequences and cardiac contrast-enhanced computed tomography for LM detection and quantification. We also briefly summarize LM prevalence in different cohorts of postinfarct patients and review the clinical utility of cardiac imaging in exploring myocardial LM as an arrhythmogenic substrate in patients with prior myocardial infarction.

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Ventricular Myocardial Fat: An Unexpected Biomarker for Long-term Survival?

Cited by 6 publications

References 32 publications

Intradermal Band-like Lipomatous Metaplasia Can Be Associated With the Regression of Overlying Skin Neoplasms: A Clinicopathologic Study of 20 Cases

Intradermal Band-like Lipomatous Metaplasia Can Be Associated With the Regression of Overlying Skin Neoplasms: A Clinicopathologic Study of 20 Cases

Opportunistic screening at chest computed tomography: literature review of cardiovascular significance of incidental findings

Noninvasive Assessment of Lipomatous Metaplasia as a Substrate for Ventricular Tachycardia in Chronic Infarct

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