Computational fluid dynamics study of common stent models inside idealised curved coronary arteries

Chen, Winson X.; Poon, Eric; Hutchins, Nicholas; Thondapu, Vikas; Barlis, Peter; Ooi, Andrew

doi:10.1080/10255842.2017.1289374

Cited by 21 publications

(17 citation statements)

References 51 publications

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“…Although some of them adopted more complicated arterial models, the hemodynamic analyses were ignored in these studies. On the other hand, Chen et al (2017) only performed computational fluid dynamics study of different stent models inside curved coronary arteries, but the fluid domain was constructed basing on ideally non-deformed stent and artery. Whereas, our study considered the deformed geometry of both the stent and tissue (including plaque and artery), which may greatly influence the fluid field.…”

Section: Discussionmentioning

confidence: 99%

Structural and Hemodynamic Analyses of Different Stent Structures in Curved and Stenotic Coronary Artery

Wei

Leo

Chen

et al. 2019

Front. Bioeng. Biotechnol.

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Coronary artery stenting is commonly used for the treatment of coronary stenosis, and different stent structures indeed have various impacts on the stress distribution within the plaque and artery as well as the local hemodynamic environment. This study aims to evaluate the performance of different stent structures by characterizing the mechanical parameters after coronary stenting. Six stent structures including three commercially-shaped stents (Palmaz-Schatz-shaped, Xience Prime-shaped, and Cypher-shaped) and three author-developed stents (C-Rlink, C-Rcrown, and C-Astrut) implanted into a curved stenotic coronary artery were investigated. Structural analyses of the balloon-stent-plaque-artery system were first performed, and then followed by hemodynamic analyses. The results showed that among the three commercially-shaped stents, the Palmaz-Schatz-shaped had the least stent dogboning and recoiling, corresponding to the greatest maximum plastic strain and the largest diameter change, nevertheless, it induced the highest maximum von Mises stress on plaque, arterial intima and media. From the viewpoint of hemodynamics, the Palmaz-Schatz-shaped displayed smaller areas of adverse low wall shear stress (<0.5 Pa), low time-averaged wall shear stress (<0.5 Pa), and high oscillating shear index (>0.1). Compared to the Cypher-shaped, the C-Rcrown and C-Astrut had smaller recoiling, greater maximum plastic stain and larger diameter change, which indicated the improved mechanical performance of the Cypher-shaped stent. Moreover, both C-Rcrown and C-Astrut exhibited smaller areas of adverse low wall shear stress, and low time-averaged wall shear stress, but only the C-Rcrown displayed a smaller area of adverse high oscillating shear index. The present study evaluated and compared the performance of six different stents deployed inside a curved artery, and could be potentially utilized as a guide for the selection of suitable commercially-shaped stent for clinical application, and to provide an approach to improve the performance of the commercial stents.

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Section: Discussionmentioning

confidence: 99%

Structural and Hemodynamic Analyses of Different Stent Structures in Curved and Stenotic Coronary Artery

Wei

Leo

Chen

et al. 2019

Front. Bioeng. Biotechnol.

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“…where 's t ' is the wall traction vector calculated from the stress tensor and 'n' is the surface normal [14]. The local magnitude for the spatial WPG (N/m 3 ) is proposed to be an important initiating factor for atherosclerosis and intimal hyperplasia development.…”

Section: Methodsmentioning

confidence: 99%

Fusion of optical coherence tomography and angiography for numerical simulation of hemodynamics in bioresorbable stented coronary artery based on patient-specific model

Huang

Zhou

Mao

et al. 2017

Computer Assisted Surgery

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Three-dimensional simulations of coronary artery using finite element analysis are considered as effective means to understand the biomechanical properties after the stent was deployed. Bioresorbable vascular scaffolds are new-generation stents used by people. Intravascular optical coherence tomography is an emerging technique for detecting struts. The common 3 D reconstruction methods are using Intravascular Ultrasound (IVUS) or angiographies. However, it loses the details about geometry model. Fusing of optical coherence tomography and angiography to reconstruct the bioresorbable stented coronary artery based on patient-specific mode is an innovative method to reconstruct the high fidelity geometry. This study aimed to use computeraided design models and computational fluid dynamics research tools to conduct a systematic investigation of blood flow in an isolated artery with realistically deployed coronary stents. Some important hemodynamic factors such as wall shear stress, wall pressure and streamline were calculated. The doctors could evaluate the local hemodynamic alterations within coronary arteries after stent deployment by reconstructing the high-fidelity geometry about each clinical case.

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“…Therefore, coronary stent implantation is widely used as one of the most effective methods to treat acute vascular occlusion. Coronary stent is a wire mesh or cut tubular structure inserted into a stenosed or blocked coronary artery to improve blood flow to the myocardium subtended by that artery [4]. The metal stent is permanently placed in the coronary artery lesion.…”

Section: Introductionmentioning

confidence: 99%

A Nine Months Follow-up Study of Hemodynamic Effect on Bioabsorbable Coronary Stent Implantation

Lan

Zhou

et al. 2019

IEEE Access

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Coronary artery disease has emerged as one of the major diseases causing death worldwide. Coronary stent has great effect to improve blood flow to the myocardium subtended by that artery, in which bioresorbable vascular scaffolds are new-generation stents used by people. However, Coronary stents implantation has a risk of restenosis, which is relative to hemodynamic parameters. Most of existing literatures studied in this issue have not taken into account such important factors as the strut thickness and lumen profile, and has yet to analyze the time effects among hemodynamic parameters over a certain period of time based on individual models. In this research, we proposed a framework to assess the chronic impact of hemodynamic on coronary stent implantation. In the framework, the optical coherence tomography (OCT) is combined with angiography to reconstruct patient-specific models of bioresorbable vascular scaffolds. Then, the hemodynamics parameters are extracted through the simulated 3D models, obtaining the distribution of wall shear stress (WSS), relative residence time (RRT) and oscillatory shear index (OSI). Finally, the changes of these parameters representing the effectiveness of hemodynamics exerted on the implanted stent can be assessed to estimate the chronic impacts. By a 9-month follow-up case study, it is observed that the difference of hemodynamic parameters are not significance. Both at baseline and 9-month follow-up experiments show that the hemodynamic parameters remain normal and similar, proving that the coronary stent implantation nowadays appears to have a robust and everlasting curative effect. INDEX TERMS Bioabsorbable vascular scaffolds, optical coherence tomography, computational fluid dynamics, hemodynamic parameters at baseline, nine months follow-up.

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Computational fluid dynamics study of common stent models inside idealised curved coronary arteries

Cited by 21 publications

References 51 publications

Structural and Hemodynamic Analyses of Different Stent Structures in Curved and Stenotic Coronary Artery

Structural and Hemodynamic Analyses of Different Stent Structures in Curved and Stenotic Coronary Artery

Fusion of optical coherence tomography and angiography for numerical simulation of hemodynamics in bioresorbable stented coronary artery based on patient-specific model

A Nine Months Follow-up Study of Hemodynamic Effect on Bioabsorbable Coronary Stent Implantation

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