Comprehensive Biosafety Assessment of Additives based on Live Microorganisms

Abstract

When developing veterinary or feed preparations, a mandatory procedure is the study of their toxicological properties in living bio-objects. The purpose of this research work was to study the toxicological effect of probiotic on the basis of autochthonous microflora of birds by identifying the parameters of acute, subacute and chronic toxicity, as well as irritating characteristics in experimental laboratory animals. In studies of subacute and chronic toxicity, the pharmacodynamics of a probiotic was studied by its effect on individual metabolic parameters, morphobiochemical composition of blood, and also the growth rate of experimental laboratory animals. A complex of toxicological studies of the developed biological product showed that the probiotic does not exhibit toxic and irritating properties, stimulates hematopoiesis, erythropoiesis, there is a slight increase in the mass of laboratory animals in connection with which it can be used for its intended purpose, regardless of the dose.