Compounds from Vitex polygama active against kidney diseases

Gallo, Margareth Borges Coutinho; Vieira, Paulo C.; Fernandes, João B.; Silva, Maria Fátima das Graças Fernandes da; Salimena-Pires, Fátima R.

doi:10.1016/j.jep.2007.09.020

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…reported antioxidant property of orientin and vitexin. [24] Phytochemical constituents, such as triterpenes[1725–27] and C-glycosylflavonoids[28] containing plants showed antiurolithiatic effect. The mechanism underlying this effect is still unknown, but it is apparently related to its diuretic properties and lowering of urinary concentrations of stone-forming constituents, which may be attributed to the presence of triterpenoids and flavonoids.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats

Takawale

Mali

Kapase

et al. 2012

J Ayurveda Integr Med

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Background:In spite of advances in the present practice of medicine, the formation and growth of calculi continues to trouble mankind, as there is no satisfactory drug to treat kidney stones. In India, many indigenous drugs are in use for the treatment of urinary calculus disease.Objective:The present study was intended to determine anti-urolithiatic effect of Lagenaria siceraria fruit powder (LSFP) against sodium oxalate (NaOx) induced urolithiasis in rats.Materials and Methods:Animals were grouped as Vehicle Group (received vehicle gum acacia 2% w/v 1 mL/kg/p.o.), NaOx Group(Sodium oxalate 70 mg/kg,i.p.), LSFP Group (500 mg/kg, p.o. LSFP suspended in gum acacia 2% + Sodium oxalate 70 mg/kg), Cystone Group (500 mg/kg, p.o. Cystone suspended in gum acacia 2% + Sodium oxalate 70 mg/kg).Result:The increased severity of microscopic calcium oxalate (CaOx) crystals deposition along with increased concentration in the kidney was seen after 7 days of NaOx (70 mg/kg, i.p.) pre-treatment. LSFP (500 mg/kg, p.o.) and standard marketed formulation Cystone (500 mg/kg, p.o.) caused a significant reversal of NaOx-induced changes in ion excretion and urinary CaOx concentration in 7 days treatment.Conclusion:From the results, it was concluded that LSFP showed beneficial effect against urolithiasis by decreasing CaOx excretion and preventing crystal deposition in the kidney tubules.

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Section: Discussionmentioning

confidence: 99%

Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats

Takawale

Mali

Kapase

et al. 2012

J Ayurveda Integr Med

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“…The identification of the C ‐glycosylated flavones, orientin and isoorientin, and chlorogenic acid in CPM by HPLC‐DAD was previously reported (Aragão et al ., ; Costa et al ., ). Those compounds are well known as potent anti‐inflammatory, antinociceptive and antitumor agents (Gallo et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Anti‐Inflammatory, Antinociceptive and Cytotoxic Effects of the Methanol Extract of Cecropia pachystachya Trécul

Aragão

Lima

Silva

et al. 2012

Phytotherapy Research

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Cecropia pachystachya is widely used in the traditional medicine as anti-inflammatory, antitusive, expectorant, antiasthmatic and hypoglycemic. It is also commercially available to treat skin cancer. To validate some of the popular uses of this species, its methanol leaves extract (CPM) was tested for anti-inflammatory, antinociceptive and cytotoxic effects. The anti-inflammatory activity was evaluated by croton oil-induced ear edema test. When used orally, the anti-inflammatory effect of CPM at 300 mg/kg was similar to that of indomethacin with 53% inhibition of the ear edema. Also, results on topical treatment were similar to that of dexamethasone with 83% inhibition of the edema. To evaluate the antinociceptive activity, acetic acid-induced writhing and formalin-induced pain tests were employed. CPM (100 and 300 mg/kg) reduced the number of writhing by 61% and 67%, respectively. In both doses, the activity was comparable to the reference drug, indomethacin. The oral administration of CPM was ineffective in the first phase of formalin test but exhibited great effects on the second phase decreasing the licking time by 85% at 300 mg/kg. The cytotoxic potential of CPM was also investigated against HL60, HL60.bcl2 and Jurkat tumor cell lines and showed an inhibition of more than 50% of cell proliferation. The flavones orientin and isoorientin were detected in CPM.

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“…Extracts as well as compounds 1 to 3 , 6 , 7 , 9 , 11 to 13 , 20 to 22 , 28 to 34 were obtained in conformity with formerly described procedures (Gallo et al ., 2006a, b, c, 2008).…”

Section: Methodsmentioning

confidence: 99%

“…(Lamiaceae, formely Verbenaceae) is a widespread and well-known Brazilian species which occurs mainly in the states of Minas Gerais, Espírito Santo, Rio de Janeiro and São Paulo, and is commonly called “Tarumã”. Its leaf tea is used in folk medicine to treat kidney infections (Rodrigues, 2001; Gallo et al ., 2008). Several of its compounds had already been characterized and bioassayed (Leitão et al ., 1997; Leitão and Delle Monache, 1998; Santos et al ., 2001; Mensor et al ., 2001), but none was regarded as neither potential trypanocidal nor enzyme inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Inhibitory Activity and Trypanocidal Effects of Extracts and Compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

Gallo

Marques

Vieira

et al. 2008

Zeitschrift Für Naturforschung C

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Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T. brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T. cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

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Compounds from Vitex polygama active against kidney diseases

Cited by 15 publications

References 7 publications

Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats

Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats

Anti‐Inflammatory, Antinociceptive and Cytotoxic Effects of the Methanol Extract of Cecropia pachystachya Trécul

Enzymatic Inhibitory Activity and Trypanocidal Effects of Extracts and Compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

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