Compositional changes of a dicalcium phosphate dihydrate cement after implantation in sheep

Bohner, Marc; Theiss, Felix; Apelt, Detlef; Hirsiger, W; Houriet, R.; Rizzoli, G.; Gnos, Edwin; Frei, C.; Auer, Jörg A; Rechenberg, Brigitte von

doi:10.1016/s0142-9612(03)00234-5

Cited by 137 publications

(105 citation statements)

References 13 publications

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“…It is also important to note the inverse relationship between the largest pore size and critical tensile strength, as noted by Griffith [33]. A number of other factors are known to influence cement strength, including the degree of residual product, which may act as an aggregate and positively impact stress resistance if it is of a higher density [34] and [35]. Compared with cast samples, the average compressive strength was shown to improve as a result of injection and addition of gentamicin to the liquid phase, i.e.…”

Section: 1mentioning

confidence: 98%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calciumphosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (b28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections.

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Section: 1mentioning

confidence: 98%

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Cox

Jamshidi

Eisenstein

et al. 2016

Materials Science and Engineering: C

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“…Generally, in the same animal model, a degradation rate decreases with a sample size increases, as does DCPD to CDHA conversion time. The compositional changes of a brushite cement after implantation in sheep is well described elsewhere [350,379].…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 98%

“…They include sodium hydrogen pyrophosphate (Na 2 H 2 P 2 O 7 ) and magnesium sulfate (according to another study, ions of citrate, sulfate and pyrophosphate are necessary [222]), which are added in amounts < 1 wt. % [350]. Application of biocompatible α-hydroxylated organic acids (glycolic, lactic, malic, tartaric and citric acids) and their calcium and sodium salts for modification of both rheological and setting properties of calcium orthophosphate cements is well described elsewhere [351,352].…”

Section: Properties Improvingmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…Charriè re et al have shown that, after setting, brushite is less mechanically stable than apatite and, therefore, also needs stable internal fixation [25]. Its characteristics and biocompatibility have been intensively investigated in recent biomechanical and animal studies [17,23,24,26,27], yet, no data has, so far, been published regarding the use of brushite cement in humans. Thus, a prospective clinical study was performed to observe the suitability and effectiveness of an injectable brushite-based cement (chronOS Inject) in filling metaphyseal defects, especially at the targeted locations of the proximal tibia and distal radius.…”

Section: Introductionmentioning

confidence: 99%

A New Injectable Brushite Cement: First Results in Distal Radius and Proximal Tibia Fractures

Ryf¹,

Goldhahn

Radziejowski

et al. 2009

Eur J Trauma Emerg Surg

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Compositional changes of a dicalcium phosphate dihydrate cement after implantation in sheep

Cited by 137 publications

References 13 publications

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

A New Injectable Brushite Cement: First Results in Distal Radius and Proximal Tibia Fractures

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