A New Injectable Brushite Cement: First Results in Distal Radius and Proximal Tibia Fractures

Ryf, Christian; Goldhahn, Sabine; Radziejowski, M.J.; Blauth, M.; Hanson, Beate

doi:10.1007/s00068-009-8165-6

Cited by 25 publications

(12 citation statements)

References 41 publications

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“…In addition, it can effectively encourage angiogenesis by upregulating nitric oxide synthase (NOS) leading to increased VEGF production [36]. In some cases, leakage of the brushite cement has been observed into the adjacent tissues, but it is ultimately resorbed without causing any significant complications [51]. Similar observations were also noted in microstructural evaluation using SEM.…”

Section: Discussionmentioning

confidence: 86%

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization andin vivoosteogenesis evaluation

Vahabzadeh

Bandyopadhyay

Bose

et al. 2015

Integrative Biology

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Dopants play critical roles in controlling the physical, mechanical, degradation kinetics, and in vivo properties of calcium phosphates. The aim of the present study was to evaluate the effects of Silicon (Si) and Zinc (Zn) dopants on physico-mechanical, and in vivo osteogenesis properties of brushite cements (BrCs) alone and in combination with insulin like growth factor 1(IGF-1). Although addition of 0.5 wt.% Si did not alter the setting time, β-TCP content, and compressive strength of BrCs significantly, 0.25 wt. % Zn incorporation was accompanied by a significant decrease in mechanical strength from 4.78±0.21 MPa for pure BrC to 3.78±0.59 MPa and 3.28±0.22 MPa for Zn-BrC and Si/Zn-BrC, respectively. The in vivo bone regeneration properties of doped BrCs alone and in combination with IGF-1 were assessed and compared using chronological radiography, histology, scanning electron microscopy and fluorochrome labeling after 2 and 4 months post implantation in rabbit femoral defect model. Based on different in vivo characterization, better osteogenesis and vasculogenesis was observed for Si-BrC and Si/Zn-BrC, whereas moderate bone regeneration was found in Zn-BrC as compared to pure BrCs. Excellent bone regeneration was observed when doped BrCs were combined with IGF-1. Our findings signify that addition of Si and/or Zn alters the physico-mechanical properties of BrCs and promotes the early stage in vivo osseointegration and bone remodeling properties. Moreover, addition of IGF-1 further improved the performance of BrCs in terms of bone regeneration in animal model.

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Section: Discussionmentioning

confidence: 86%

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization andin vivoosteogenesis evaluation

Vahabzadeh

Bandyopadhyay

Bose

et al. 2015

Integrative Biology

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“…This phase conversion effect has not been observed with monetite biomaterials and they have a greater amount of new bone formation and infiltration associated with them [333]. Resorbable and injectable brushite cements have been investigated for use in treating metaphyseal bone defects [136,340]. Brushite cements have also been used for treatment of fractures in the tibial plateau [136] and distal metaphysic bone [340].…”

Section: Biodegradable Materialsmentioning

confidence: 99%

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

et al. 2015

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This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.

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“…Besides, other successful attempts have been made to use these formulations for calcaneal fractures [509], hip fractures [510,511], augmentation of osteoporotic vertebral bodies [512], distal radius fractures [513], tibial plateau fractures [33,[513][514][515][516][517], restoration of pedicle screw fixation [518,519], reinforcement of thoracolumbar burst fractures [520], cancellous bone screws [521,522], in wrist arthrodesis [523] and for fixation of titanium implants [524]. A recent study on a cement augmentation of the femoral neck defect might be found elsewhere [525].…”

Section: Orthopaedic Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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A New Injectable Brushite Cement: First Results in Distal Radius and Proximal Tibia Fractures

Cited by 25 publications

References 41 publications

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization andin vivoosteogenesis evaluation

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization andin vivoosteogenesis evaluation

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

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