Composition and biological activities of different extracts of <i>Salvia jurisicii</i>, a rare and endemic Macedonian species

Alimpić, Ana; Knežević, Aleksandar; Šavikin, K.; Ćurčić, Milena; Veličković, Dragan T.; Stević, Tatjana; Matevski, Vlado; Stajić, Mirjana; Marković, Snežana D.; Marin, Petar D.; Duletić-Laušević, Sonja

doi:10.1080/11263504.2016.1219414

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…The infusion prepared at 5% rate yielded 15.48 ± 0.14% (w/w) of extract. Table 1 (Kocak et al, 2016), and S. jurisicii 14.27 ± 0.09 mg GAE/g DW despite the 24 h maceration time and the use of ultrasound bath (Alimpić et al, 2017). Even when methanol-water 70% and ethanol were used as solvents, which are known to have a high recovery, the phenolic compounds rate was 1981.56 ± 32.13 mg GAE/100g (Poyraz et al, 2017).…”

Section: Phytochemical Analysismentioning

confidence: 99%

“…According to Grzegorczyk-Karolak and Kiss (2018) a FRAP activity between 890 and 1575 μmol FSE/g extract were obtained for decoction, infusion, and ethanolic extracts of S. viridis. Alimpić et al (2017) evaluated the decoction and ethanolic extract of S. jurisicii (277.14 ± 8.6, 136.95 μg/mL and LOQ = 414.98 μg/mL), caffeic acid (y = 388345x + 406369, R 2 = 0.9939, LOD = 8.57 μg/mL and LOQ = 25.97 μg/mL), chlorogenic acid (y = 168823x -161172, R 2 = 0.9999, LOD = 0.83 μg/mL and LOQ = 2.50 μg/mL), naringenin (y = 18433x + 78903, R 2 = 0.9998, LOD = 18.66 μg/mL and LOQ = 56.55 μg/mL), rosmarinic acid (y = 191291x-652903, R 2 = 0.999, LOD = 3.70 μg/mL and LOQ = 11.22 μg/mL), quercetin-3-O-glucoside (y = 34843x-160173, R 2 = 0.9998, LOD = 17.01 μg/mL and LOQ = 51.54 μg/mL), and syringic acid (y = 376056x + 141329, R 2 = 0.9995, LOD = 2.37 μg/mL and LOQ = 7.18 μg/mL). TPA: total phenolic acids, TF: total flavonoids, TPC: total phenolic compounds.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: Chemical, toxicological and bioactivities characterization

Semaoui

Ouafi

Machado

et al. 2021

Journal of Ethnopharmacology

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Salvia chudaei Batt. & Trab. from Algeria is traditionally used to relieve several dysfunctions, including inflammatory and pain-related situations.Aim of the study: This work aimed to confirm scientifically the referred properties. For that, the phenolic composition and antioxidant activity were evaluated as well as acute toxicity, anti-inflammatory and analgesic effects of different doses of the infusion of S. chudaei aerial parts. Materials and methods: Infusion of aerial parts of S. chudaei was prepared and screened for phenolic composition by generalized methods TPC and TFC then by LC-DAD-ESI/MSn. DPPH and FRAP were used to evaluate antioxidant activity. Using mice, acute toxicity, anti-inflammatory by carrageenan-induced paw edema, and analgesic by acetic acid-induced writhing and formalin-induced pain activities were tested. Results: The infusion showed 2018 mg GAE/100g DW of phenolics and 1956 mg ECE/100g DW of flavonoids. Phenolic profile by LC-DAD-ESI/MSn revealed the presence of ten compounds: syringic acid hexoside derivative, kaempferol-O-diglucuronide, kaempferol-O-deoxyhexoside-hexoside, kaempferol-O-glucuronide, apigenin-O-diglucuronide, caffeic acid, 4-O-caffeoylquinic acid, eriodictyol-O-glucuronide, rosmarinic acid hexoside, and rosmarinic acid. This acid was the major compound representing 54% of the total content of the identified compounds and an absolute content of 18 mg/g of extract. Additionally, the infusion exhibited a good antioxidant activity (DPPH: 81 μmol TE/g DW, FRAP: 438 μmol FSE/g DW). By oral administration to mice, the infusion showed a significant (p<0.05) dose-dependent reduction of carrageenan-induced inflammation and inhibition of formalin-induced pain (late and early phase) and acetic acid-induced writhing compared with the control. On the other hand, infusion up to 8 g/kg b.w. showed no signs of toxicity or mortality. Conclusion:This study reveals, for the first time, that the infusion of the aerial parts of S. chudaei is not toxic in a single dose and has remarkable antioxidant, antiinflammatory, and analgesic activities, supporting the use of this species in folk medicine.

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Section: Phytochemical Analysismentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: Chemical, toxicological and bioactivities characterization

Semaoui

Ouafi

Machado

et al. 2021

Journal of Ethnopharmacology

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show abstract

“…Specific phenolic and flavonoids may contribute to the biological activity of plant methanol extracts (Carocho and Ferreira 2013;Katanić et al 2015;Alimpić et al 2016). Several phenolic acids and flavonoids were detected by HPLC analysis in the investigated plants.…”

Section: Discussionmentioning

confidence: 98%

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

et al. 2019

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The paper investigates anticancer effects of methanol extracts of invasive plant species Robinia pseudoacacia L. (RpE) and Amorpha fruticosa L. (AfE) on breast cancer MDA-MB-231 and healthy MRC-5 cells. The anticancer activity was evaluated through examination of cytotoxic effects, anti-invasive potential and impact on redox status in comparative analysis using their chemical composition. According to the IC 50 values, the investigated plants had no significant cytotoxic effects either on healthy cell line MRC-5 or on MDA-MB-231 cancer cells, but they showed great anti-invasive potential by suppressing all investigated parameters of tumor invasion and metastases (Matrix Metalloproteinases (MMP), protein concentration and MMP-9, C-X-C Motif Chemokine Ligand 12 (CXCL-12), Vascular Endothelial Growth Factor (VEGF-A) and Hypoxia-Inducible Factor (HIF-1α) gene expression) in MDA-MB-231 cells. Based on their remarkable anti-invasive potential, RpE and AfE are suitable for use as potential supplements in anticancer therapy or as nutritional food supplements.

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Anticancer Activity of Secondary Metabolites of Teucrium Species

Milutinović

Cvetković

2020

Teucrium Species: Biology and Applications

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Composition and biological activities of different extracts of Salvia jurisicii, a rare and endemic Macedonian species

Cited by 11 publications

References 30 publications

Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: Chemical, toxicological and bioactivities characterization

Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: Chemical, toxicological and bioactivities characterization

The anti-invasive activity of Robinia pseudoacacia L. and Amorpha fruticosa L. on breast cancer MDA-MB-231 cell line

Anticancer Activity of Secondary Metabolites of Teucrium Species

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