Anticancer Activity of Secondary Metabolites of Teucrium Species

Milutinović, Milena; Cvetković, Danijela

doi:10.1007/978-3-030-52159-2_13

Cited by 4 publications

(2 citation statements)

References 150 publications

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“…It has been reported that natural substances may show selective anticancer activity, induce apoptosis in cancer cells, and provoke lower adverse effects on healthy cells. Among them, secondary metabolites produced by plants or fungi constitute a relevant source of promising anticancer agents [ 105 , 106 , 107 , 108 , 109 ]. Additionally, it has been reported that proteins from other natural sources, such as animal venoms or protein structure such as fibroin and sericin from insects’ silk, also show selective anticancer and proapoptotic activity [ 110 , 111 , 112 ].…”

Section: Potential Application Of Colicins and Microcinsmentioning

confidence: 99%

Colicins and Microcins Produced by Enterobacteriaceae: Characterization, Mode of Action, and Putative Applications

Marković

Grujović

Koraćević

et al. 2022

IJERPH

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Enterobacteriaceae are widely present in many environments related to humans, including the human body and the food that they consume, from both plant or animal origin. Hence, they are considered relevant members of the gastrointestinal tract microbiota. On the other hand, these bacteria are also recognized as putative pathogens, able to impair human health and, in food, they are considered indicators for the microbiological quality and hygiene status of a production process. Nevertheless, beneficial properties have also been associated with Enterobacteriaceae, such as the ability to synthesize peptides and proteins, which can have a role in the structure of microbial communities. Among these antimicrobial molecules, those with higher molecular mass are called colicins, while those with lower molecular mass are named microcins. In recent years, some studies show an emphasis on molecules that can help control the development of pathogens. However, not enough data are available on this subject, especially related to microcins. Hence, this review gathers and summarizes current knowledge on colicins and microcins, potential usage in the treatment of pathogen-associated diseases and cancer, as well as putative applications in food biotechnology.

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Section: Potential Application Of Colicins and Microcinsmentioning

confidence: 99%

Colicins and Microcins Produced by Enterobacteriaceae: Characterization, Mode of Action, and Putative Applications

Marković

Grujović

Koraćević

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…As pointed by the authors, only a thorough understanding of their bioavailability, pharmacodynamics, and modes of action, according to the author, would allow for the development of a new generation of standardized, successful biopreparations [ 12 ]. An overview of existing in vitro and in vivo evidence supporting the anticancer potential is also presented, and the comparative analysis of results may contribute to a better understanding of probable mechanisms of action and encourage future studies into the Teucrium species potential as adjuvant chemotherapeutics [ 13 ]. A comprehensive examination of how Teucrium species high amounts of flavonoids, phenolic acids, and terpenoids directly contribute to anticholinesterase, anti-diabetic, and anti-inflammatory activity, making them attractive candidates for possible future applications, is also presented [ 14 ].…”

mentioning

confidence: 99%