Composition analysis and anti-hypoxia activity of polysaccharide from Brassica rapa L.

Xie, Yue; Jiang, Si‐Ping; Su, Donghai; Pi, Ningning; Ma, Chao; Gao, Ping

doi:10.1016/j.ijbiomac.2010.07.008

Cited by 45 publications

(31 citation statements)

References 21 publications

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“…In clinical trials, various herbs have been used to alleviate the symptoms of fatigue and hypoxia (10,22,26). The aim of the present study was to investigate the antifatigue and antihypoxic effects of PHC and examine the underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Intense exercise results in the accumulation of reactive free radicals and leads to the consumption of adenosine triphosphate (ATP) and glycogen (9). Energy metabolism is involved in the pathophysiology of fatigue, and hypoxia, which occurs during acute and chronic vascular disease, cancer and stroke, is defined as a decrease in the normal level of tissue oxygen tension (10). As reported previously, hypoxia is also associated with energy metabolism (11).…”

Section: Introductionmentioning

confidence: 87%

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Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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Abstract. Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti-inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant-associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)-5'-monophosphate (AMP)-activated protein kinase (AMPK), p-protein kinase B (AKT) and p-mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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“…Significant differences between the five groups are noted by a and b (P<0.05) 2006). High levels of Hb and RBC could enhance the endurance of hypoxia (Xie et al 2010), which could be the mechanism of anti-hypoxia activity of YMP. The contents of fat and protein between YMP and CMP are at the same levels, which ensured mice in YMP-M and CMP groups received the same levels of fat and protein.…”

Section: Resultsmentioning

confidence: 99%

“…The sodium nitrite toxicosis test was carried out according to Xie et al (2010). One hour after last treatment, the weights of mice were measured.…”

Section: Sodium Nitrite Toxicosis Testmentioning

confidence: 99%

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A preliminary study on anti-hypoxia activity of yak milk powder in vivo

Zhang

Cao

et al. 2014

Dairy Sci. & Technol.

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International audienceYak milk is the main source of dietary protein, fat, and micronutrients for Tibetan residents, who live at a high altitude and oxygen-deficient environment. The anti-hypoxia activity of yak milk powder (YMP) was investigated in mouse hypoxia models, using the normobaric hypoxia test, sodium nitrite toxicosis test, and hematological parameters analyses. The results showed that YMP could prolong the survival time under both normobaric hypoxia and sodium nitrite toxicosis conditions by 15.7%–17.3% and 13.9%–15.1%, respectively, and increase the levels of red blood cells (RBC) and blood hemoglobin (Hb). Furthermore, YMP was better than cow milk powder (CMP) in anti-hypoxia activity. YMP could be explored as a novel anti-hypoxia functional food ingredient

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Effects of Glucosinolates from Turnip (Brassica rapa L.) Root on Bone Formation by Human Osteoblast‐Like MG‐63 Cells and in Normal Young Rats

Jeong

Park

Hyun

et al. 2015

Phytotherapy Research

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Turnip (Brassica rapa L.) root ethanol extract (TRE) was prepared, and its chemical constituents were characterized by ultra-performance liquid chromatography and mass spectrometry. Thirteen glucosinolates (GSLs) were identified, comprising eight aliphatic, four indolic, and one aromatic compounds. The effects of these GSLs on bone formation were investigated in vitro by incubating human osteoblast-like MG-63 cells with TRE and then analyzing their viability, alkaline phosphatase (ALP) activity, collagen content, and mineralization and in vivo by administering TRE orally to normal young rats (500 mg/kg/day) and assessing subsequent changes in serum osteocalcin and bone microstructure in these animals. No TRE-related toxicity was found, and the levels of cell viability, ALP activity, collagen synthesis, and mineralization were significantly increased relative to the negative control. In particular, stimulatory effects on the differentiation of MG-63 cells were strongly enhanced as compared with a positive control (daidzein). Serum osteocalcin was also significantly increased, and some important bone microstructural parameters were improved in TRE-administered rats compared with their saline-administered counterparts. GSLs therefore appear to have a stimulatory effect on bone formation in both MG-63 cells and normal young rats. This is the first report on the usefulness of turnip root and its GSL compounds for bone formation.

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Composition analysis and anti-hypoxia activity of polysaccharide from Brassica rapa L.

Cited by 45 publications

References 21 publications

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

A preliminary study on anti-hypoxia activity of yak milk powder in vivo

Effects of Glucosinolates from Turnip (Brassica rapa L.) Root on Bone Formation by Human Osteoblast‐Like MG‐63 Cells and in Normal Young Rats

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