A preliminary study on anti-hypoxia activity of yak milk powder in vivo

Abstract

International audienceYak milk is the main source of dietary protein, fat, and micronutrients for Tibetan residents, who live at a high altitude and oxygen-deficient environment. The anti-hypoxia activity of yak milk powder (YMP) was investigated in mouse hypoxia models, using the normobaric hypoxia test, sodium nitrite toxicosis test, and hematological parameters analyses. The results showed that YMP could prolong the survival time under both normobaric hypoxia and sodium nitrite toxicosis conditions by 15.7%–17.3% and 13.9%–15.1%, respectively, and increase the levels of red blood cells (RBC) and blood hemoglobin (Hb). Furthermore, YMP was better than cow milk powder (CMP) in anti-hypoxia activity. YMP could be explored as a novel anti-hypoxia functional food ingredient

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

“…Fatigue is characterized by a physical and/or mental weariness, which results in negative effects on work performance and exercise intensity, family life and social relationships (7). Physical fatigue, a complex condition, is described as a time-dependent, exercise-induced reduction in the maximal force-generating capacity of a muscle (8).…”

“…Additionally, the majority of the broad-spectrum drugs exhibit adverse effects (18). Delaying the occurrence of fatigue and hypoxia, and promoting rapid recovery are current foci of medical investigations (7). The prevalence of potential alternative medicines derived from herbs have been increasing worldwide, which can be used not only for medicinal purposes, but also for food preservation, as dietary supplements or functional foods, and in cosmetics (17).…”

Yak milk protects against alcohol-induced liver injury in rats

“…Previous studies have emphasized the multifaceted benefits of YM, encompassing its anti-inflammatory, anti-oxidative, antihypoxic, and anti-fatigue properties, as well as its capacity to regulate the fecal microbiota effects. 22,23,27,33,34 Alcoholic liver injury entails oxidative stress, disrupted lipid synthesis, endoplasmic reticulum stress, and liver-intestine interaction. [35][36][37] However, the potential of YM as a preventive measure against alcohol-induced liver injury needs further investigation.…”

Association between Single Nucleotide Polymorphisms of PRKD1 and KCNQ3 Gene and Milk Quality Traits in Gannan Yak (Bos grunniens)

“…Iron is an important element to produce hemoglobin, and hemoglobin is the carrier of oxygen in animals, which is crucial in the hypoxic plateau environment. It is reported that yak milk can prolong the survival time of mice under normal hypoxic conditions and improve their red blood cells and hemoglobin levels; thus, yak milk may indirectly improve the oxygen-carrying function of plateau people [ 32 , 33 ]. As an important antioxidant, selenium helps to protect cells from damage [ 32 ].…”