Composites based on heparin and MIL-101(Fe): the drug releasing depot for anticoagulant therapy and advanced medical nanofabrication

Vinogradov, Vladimir V.; Drozdov, Andrey S.; Mingabudinova, Leila R.; Shabanova, Emiliya M.; Колчина, Н. В.; Anastasova, Elizaveta I.; Markova, Alina A.; Shtil, Alexander А.; Milichko, Valentin A.; Старова, Галина Л.; Precker, Rafaella L. M.; Vinogradov, Alexandr V.; Hey‐Hawkins, Evamarie; Pidko, Evgeny A.

doi:10.1039/c8tb00072g

Cited by 36 publications

(15 citation statements)

References 48 publications

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“…Density functional theory (DFT) calculations were performed using the Gaussian 09 D.01 50 program suite to study the structural properties of Mn-BTC MOF and elucidate its stability towards the oxidizing species (O 2 and H 2 O 2 ) in water. Similar to our previous work on an MOF-based drug delivery system, 51 all calculations were carried out at the PBE-D3/6-311++G(d,p)// PBE-D3/6-31G(d,p) level of theory. 52,53 Dispersion attraction was accounted for using the empirical correction scheme proposed by Grimme.…”

Section: Methodsmentioning

confidence: 99%

Degradation paths of manganese-based MOF materials in a model oxidative environment: a computational study

Khramenkova

Polynski

Виноградов

et al. 2018

Phys. Chem. Chem. Phys.

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Stability is the key property of functional materials. In this work we investigate computationally the degradative potential of a model Mn-BTC (BTC = benzene-1,3,5-tricarboxylate) metal-organic framework (MOF) building block in aqueous solutions under oxidative conditions. Model density functional theory calculations have shown that the direct hydrolysis of the Mn-containing moieties is more difficult than their decomposition via oxidation-induced paths. While the interaction with H2O2 species is of non-covalent nature and requires O-O-bond breaking to initiate Mn-center oxidation, open-shell O2 species readily oxidize radical Mn-centers and form bonds of σ-, π-, or δ-symmetry with the metal. The oxidative transformations of di-Mn paddle-wheel carboxylate structure-forming units are accompanied with substantial distortions of the coordination polyhedra that, together with the increased Lewis acidity of the oxidized metal centers, facilitates the hydrolysis leading to the degradation of the structure at a larger scale. Whereas such a mechanism is expected to hamper the catalytic applications of such Mn-MOFs, the associated structural response to oxidizing and radical species can create a basis for the construction of Mn-MOF-based drug delivery systems with increased bio-compatibility.

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Section: Methodsmentioning

confidence: 99%

Degradation paths of manganese-based MOF materials in a model oxidative environment: a computational study

Khramenkova

Polynski

Виноградов

et al. 2018

Phys. Chem. Chem. Phys.

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“…In this approach, the protein is immobilized in the xerogel boehmite cage during the room-temperature sol-gel transition 28,29 . It was shown, that it is possible to obtain systems both with complete immobilization of biomacromolecules and partial release of the proteins depending on the ratio of components and environmental conditions 26,27 . The entrapped proteins tightly interact with the walls of the ceramic matrix, which leads to an increase of their thermo- and photo-stability, so the structure of the immobilized protein can be preserved even at temperatures above the denaturation temperature under normal conditions 28–30 .…”

Section: Introductionmentioning

confidence: 99%

Sol-gel derived boehmite nanostructures is a versatile nanoplatform for biomedical applications

Solovev

Prilepskii

Krivoshapkina

et al. 2019

Sci Rep

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Alumina is one of the most promising carriers for drug delivery due to the long history of its usage as a vaccine adjuvant. Sol-gel synthesis provides excellent conditions for entrapment of biomolecules within an inorganic cage providing stabilization of proteins under the extremal conditions. In this paper, we show in vitro investigation of monodisperse alumina xerogel nanocontainers (AXNCs) using bovine serum albumin as a model protein entrapped in sol-gel alumina building blocks. Particularly, dose and cell-type dependent cytotoxicity in HeLa and A549 cancer cell lines were employed as well as investigation of antibacterial effect and stability of AXNCs in different biological media. It was shown, that the release of entrapped protein could be provided only in low pH buffer (as in cancer cell cytoplasm). This property could be applied for anticancer drug development. We also discovered boehmite nanoparticles effect on horizontal gene transfer and observed the appearance of antibiotic resistance by means of exchanging of the corresponding plasmid between two different E. coli strains. The present work may help to understand better the influence of AXNCs on various biological systems, such as prokaryotic and eukaryotic cells, and the activity of AXNCs in different biological media.

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“…The magnetic field is a promising physical tool to control particle dynamic media due to the absence of energy dissipation in biological media, and the ability to generate heat by magnetic hyperthermia and mechanical force via magnetically induced particle oscillation and rotation under the action of an alternating magnetic field [ 161 , 162 ]. However, most papers describe the application of isotropic nanosized particles [ 163 ], as well as the mutual interaction of magnetic nanoparticle results in terms of vortex formation, which is efficiently operated by a magnetic field, and have been focused on accurate therapy [ 164 , 165 , 166 ] and cargo delivery [ 167 , 168 ]. Dong et al designed a magnetic vortex (microswarm) consisting of porous magnetite particles, which, under the action of the rotating magnetic field, could disrupt the biofilm and generate ROS [ 169 ].…”

Section: Biological Effect and Applicationmentioning

confidence: 99%

Nanomaterial Shape Influence on Cell Behavior

Kladko

Falchevskaya

Serov

et al. 2021

IJMS

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Nanomaterials are proven to affect the biological activity of mammalian and microbial cells profoundly. Despite this fact, only surface chemistry, charge, and area are often linked to these phenomena. Moreover, most attention in this field is directed exclusively at nanomaterial cytotoxicity. At the same time, there is a large body of studies showing the influence of nanomaterials on cellular metabolism, proliferation, differentiation, reprogramming, gene transfer, and many other processes. Furthermore, it has been revealed that in all these cases, the shape of the nanomaterial plays a crucial role. In this paper, the mechanisms of nanomaterials shape control, approaches toward its synthesis, and the influence of nanomaterial shape on various biological activities of mammalian and microbial cells, such as proliferation, differentiation, and metabolism, as well as the prospects of this emerging field, are reviewed.

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Composites based on heparin and MIL-101(Fe): the drug releasing depot for anticoagulant therapy and advanced medical nanofabrication

Abstract: We describe the synthesis and properties of a new composite material based on heparin and MIL-101(Fe) metal–organic framework.

Cited by 36 publications

References 48 publications

Degradation paths of manganese-based MOF materials in a model oxidative environment: a computational study

Degradation paths of manganese-based MOF materials in a model oxidative environment: a computational study

Sol-gel derived boehmite nanostructures is a versatile nanoplatform for biomedical applications

Nanomaterial Shape Influence on Cell Behavior

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